Molecular classification of hepatocellular carcinoma anno 2011

Malenstein, Hannah van; Pelt, Jos van; Verslype, Chris

doi:10.1016/j.ejca.2011.04.027

Cited by 70 publications

(56 citation statements)

References 85 publications

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“…It is well documented that a defect in cell-cycle control is an essential step in the development and progression of human cancer. A number of oncogenes and tumor suppressors involved in cell-cycle regulation are often aberrant in hepatocellular carcinoma, thereby promoting cancer cell proliferation (2).…”

Section: Introductionmentioning

confidence: 99%

miRNA-302b Suppresses Human Hepatocellular Carcinoma by Targeting AKT2

Yao

Zhang

Guo

et al. 2014

Molecular Cancer Research

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miRNAs (miR) play a critical role in human cancers, including hepatocellular carcinoma. Although miR-302b has been suggested to function as a tumor repressor in other cancers, its role in hepatocellular carcinoma is unknown. This study investigated the expression and functional role of miR-302b in human hepatocellular carcinoma. The expression level of miR-302b is dramatically decreased in clinical hepatocellular carcinoma specimens, as compared with their respective nonneoplastic counterparts, and in hepatocellular carcinoma cell lines. Overexpression of miR-302b suppressed hepatocellular carcinoma cell proliferation and G 1 -S transition in vitro, whereas inhibition of miR-302b promoted hepatocellular carcinoma cell proliferation and G 1 -S transition. Using a luciferase reporter assay, AKT2 was determined to be a direct target of miR-302b. Subsequent investigation revealed that miR-302b expression was inversely correlated with AKT2 expression in hepatocellular carcinoma tissue samples. Importantly, silencing AKT2 recapitulated the cellular and molecular effects seen upon miR-302b overexpression, which included inhibiting hepatocellular carcinoma cell proliferation, suppressing G 1 regulators (Cyclin A, Cyclin D1, CDK2) and increasing p27Kip1 phosphorylation at Ser10. Restoration of AKT2 counteracted the effects of miR302b expression. Moreover, miR-302b was able to repress tumor growth of hepatocellular carcinoma cells in vivo.

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Section: Introductionmentioning

confidence: 99%

miRNA-302b Suppresses Human Hepatocellular Carcinoma by Targeting AKT2

Yao

Zhang

Guo

et al. 2014

Molecular Cancer Research

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“…H epatocellular carcinoma (HCC) is an epithelial tumor originating in the liver and composed of cells with characteristics similar to those of normal hepatocytes (1). It is the fifth most common tumor in the world, and its incidence is increasing, especially in Western nations (2).…”

mentioning

confidence: 99%

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part I. Development, Growth, and Spread: Key Pathologic and Imaging Aspects

2014

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“…The definitions of cancer stem cells (CSCs) are confusing, since CSCs can both generate and be derived from malignant tumours (Reya et al, 2001;Clarke et al, 2006;Rahman et al, 2011;van Malenstein et al, 2011;Magee et al, 2012;Valent et al, 2012). Generally, the definition of CSCs is a function of their experimental derivation as an isolate from tumour, and as a precursor to a secondary tumour.…”

Section: Problems Surrounding Hcc Cell Originsmentioning

confidence: 99%

“…The cellular origins of HCC are a long-standing problem in liver research (Sell andLeffert, 1982, 2008), compounded by the complex clinical phenotypes of HCCs (van Malenstein et al, 2011). The definitions of cancer stem cells (CSCs) are confusing, since CSCs can both generate and be derived from malignant tumours (Reya et al, 2001;Clarke et al, 2006;Rahman et al, 2011;van Malenstein et al, 2011;Magee et al, 2012;Valent et al, 2012).…”

Section: Problems Surrounding Hcc Cell Originsmentioning

confidence: 99%