Molecular characterization, relatedness and antifungal susceptibility of the basidiomycetous hormographiella species and Coprinus cinereus from clinical and environmental sources

Gené, Josepa; Guillamón, José Manuel; Guarro, Josep; Pujol, Isabel; Ulfig, Krzysztof

doi:10.1007/bf00393569

Cited by 62 publications

(37 citation statements)

References 16 publications

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“…has been shown to be involved in the formation of a secondary pulmonary fungal ball but not in invasive disease (4). In contrast, recurrent invasive infections, in addition to pulmonary colonization, are observed with the members of Agaricales, Hormographiella aspergillata and Hormographiella verticillata (5,6,(8)(9)(10)(25)(26)(27)(28), and in V. volvacea (18). These mushrooms have a ruderal strategy (29), colonizing compost, dung, self-heated wood chips, and similar substrates.…”

Section: Discussionmentioning

confidence: 99%

“…(anamorph, Hormographiella spp. ), and Phanerochaete chrysosporium (anamorph, Sporotrichum pruinosum), possess some morphological characteristics specific for their identification (4)(5)(6)(7)(8)(9)(10). Lately, lesser known members from this class of molds, such as Bjerkandera adusta (11), Cyclomyces tabacinus (12), Irpex lacteus (13), Inonotus (Phellinus) tropicalis (14,15), Phellinus undulatus (16), Oxyporus corticola (17), Volvariella volvacea (18), and Perenniporia spp.…”

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confidence: 99%

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Clinical Significance of Filamentous Basidiomycetes Illustrated by Isolates of the Novel Opportunist Ceriporia lacerata from the Human Respiratory Tract

et al. 2013

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eThe filamentous basidiomycete Ceriporia lacerata, an agent of white rot on wood, has never been reported in human disease and its clinical significance is not yet known. We describe 4 patients with respiratory diseases where C. lacerata was implicated in a wide spectrum of clinical manifestations ranging from saprobic colonization to fungal pneumonia. The isolates did not show the morphological characteristics that facilitate recognition of filamentous basidiomycetes, such as the presence of clamp connections, spicules along hyphae, or fruiting bodies. The identity of the mold was confirmed by sequencing the internal transcribed spacer 1 and 4 (ITS-1 and ITS-4) and D1/D2 regions of the rRNA gene. All of the isolates exhibited the lowest MICs of posaconazole and isavuconazole (MIC range, 0.06 to 0.125 g/ml), followed by itraconazole (MIC range, 0.06 to 0.5 g/ml), voriconazole (MIC range, 0.125 to 0.5 g/ml), and amphotericin B (MIC range, 0.25 to 1 g/ml). The infections reported here occurred in patients with preexisting lung damage induced by tuberculosis or chronic obstructive pulmonary disease. Chronic, sometimes fatal infections by the ascomycete Aspergillus fumigatus and the basidiomycete Schizophyllum commune are well established in the presence of an anatomical pulmonary defect or in the background of immunodeficiency. It is postulated that C. lacerata, a novel opportunist basidiomycete, may be involved in similar pathological processes.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Clinical Significance of Filamentous Basidiomycetes Illustrated by Isolates of the Novel Opportunist Ceriporia lacerata from the Human Respiratory Tract

et al. 2013

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“…It has also been implicated in allergic bronchopulmonary disease (1,22), chronic sinusitis (4,25,33,45,51,52), and less serious disease of the nails (27). Coprinopsis cinerea (anamorph, Hormographiella aspergillata) (14,18) has been the causative agent in a case of prosthetic valve endocarditis (13,57) and in a fatal pulmonary infection (60). A Coprinus species was reported to cause a fatal infection in a leukemia patient 5 years after bone marrow transplantation (36).…”

Section: Few Filamentous Basidiomycetes Have Been Authenticated As Humentioning

confidence: 99%

Identification and First Report of Inonotus ( Phellinus ) tropicalis as an Etiologic Agent in a Patient with Chronic Granulomatous Disease

Sutton¹,

Thompson²,

Rinaldi

et al. 2005

J Clin Microbiol

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“…The filamentous basidiomycetes include a substantial number of NSMs that may be resistant to antifungals (3)(4)(5)(6). Nonsporulating filamentous basidiomycetes such as Hormographiella aspergillata and Volvariella volvacea are resistant to amphotericin B (AMB), caspofungin (CAS), itraconazole (ITC), voriconazole (VRC), and posaconazole (POS) and have been associated with high case fatality rates in the past (3)(4)(5)7). Although filamentous basidiomycetes are being increasingly recognized in clinical specimens, their definitive identification using conventional methods can be problematic (8,9).…”

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Clinical Significance and Molecular Characterization of Nonsporulating Molds Isolated from the Respiratory Tracts of Bronchopulmonary Mycosis Patients with Special Reference to Basidiomycetes

et al. 2013

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dNonsporulating molds (NSMs), especially basidiomycetes, have predominantly been reported as human pathogens responsible for allergic and invasive disease. Their conventional identification is problematic, as many isolates remain sterile in culture. Thus, inconclusive culture reports might adversely affect treatment decisions. The clinical significance of NSMs in pulmonary mycoses is poorly understood. We sequenced the internal transcribed spacer (ITS) region and D1/D2 domain of the larger subunit (LSU) of 52 NSMs isolated from respiratory specimens. The basidiomycetes were the predominant NSMs, of which Schizophyllum commune was the most common agent in allergic bronchopulmonary mycosis (ABPM), followed by Ceriporia lacerata in invasive fungal disease. Porostereum spadiceum, Phanaerochaete stereoides, Neosartorya fischeri, and Marasmiellus palmivorus were the other molds observed. Application of ITS and LSU region sequencing identified 92% of the isolates. The antifungal susceptibility data revealed that all basidiomycetes tested were susceptible to amphotericin B and resistant to caspofungin, fluconazole, and flucytosine. Except for 3 isolates of S. commune and a solitary isolate of M. palmivorus, all basidiomycetes had low MICs for itraconazole, posaconazole, and voriconazole. Basidiomycetes were isolated from patients with ABPM, invasive pulmonary mycosis/pneumonia, or fungal balls. In addition, the majority of the basidiomycetes were isolated from patients with chronic respiratory disorders who were sensitized to one of the basidiomycetous fungi and demonstrated precipitating antibodies against the incriminating fungi, indicating an indolent tissue reaction. Thus, isolation of basidiomycetes from the lower respiratory tract could be significant, and it is important to monitor these patients in order to prevent subsequent lung damage.

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Molecular characterization, relatedness and antifungal susceptibility of the basidiomycetous hormographiella species and Coprinus cinereus from clinical and environmental sources

Cited by 62 publications

References 16 publications

Clinical Significance of Filamentous Basidiomycetes Illustrated by Isolates of the Novel Opportunist Ceriporia lacerata from the Human Respiratory Tract

Clinical Significance of Filamentous Basidiomycetes Illustrated by Isolates of the Novel Opportunist Ceriporia lacerata from the Human Respiratory Tract

Identification and First Report of Inonotus ( Phellinus ) tropicalis as an Etiologic Agent in a Patient with Chronic Granulomatous Disease

Clinical Significance and Molecular Characterization of Nonsporulating Molds Isolated from the Respiratory Tracts of Bronchopulmonary Mycosis Patients with Special Reference to Basidiomycetes

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