Molecular characterization of two novel sub-sublineages of pigeon paramyxovirus type 1 in China

Wei, Tianchao; Deng, Qi; Li, Haiqiong; Pan, Chao; Zhai, Guosheng; Yuan, Yadong; Cheng, Ercai; Zhang, Yuanqin; Mo, Meilan; Huang, Teng; Wei, Ping

doi:10.1007/s00705-018-3950-3

Cited by 8 publications

(7 citation statements)

References 46 publications

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“…Some pigeon farms have extensively been using chicken genotype II vaccines, such as LaSota and Clone-30, in attempts to protect pigeons from ND [13].However, these vaccines have not been fully efficient and the disease has broken in many pigeon farms in China. Previous studies have identified that the predominant viruses causing ND in pigeons in China between 1996 and 2015 were of sub/genotypes VIb (now named VI.1) and VII [14,15]. More recent pigeon-derived PPMV-1 were classified as members of sub-genotypes Vik and VIj [16], which are closely related to the viruses studies here.…”

Section: Introductionsupporting

confidence: 71%

“…PPMV-1 was introduced to Hong Kong in 1985, subsequently spread throughout China, and now poses a serious threat to the Chinese pigeon breeding industry and wild birds population [12]. The virus is now one of the most destructive pathogens for pigeons in the country, also affecting pigeon farms with increased frequency (Awu et al 2015; Guo et al 2013;Ren et al 2016;Wei et al 2018).…”

Section: Introductionmentioning

confidence: 99%

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Complete Genome Sequencing, Molecular Epidemiological, and Pathogenicity Analysis of Pigeon Paramyxoviruses Type 1 Isolated in Guangxi, China during 2012–2018

Dimitrov³

et al. 2020

Viruses

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Newcastle disease is an important poultry disease that also affects Columbiform birds. The viruses adapted to pigeons and doves are referred to as pigeon paramyxoviruses 1 (PPMV-1). PPMV-1 are frequently isolated from pigeons worldwide and have the potential to cause disease in chickens. The complete genomes of 18 PPMV-1 isolated in China during 2012–2018 were sequenced by next-generation sequencing (NGS). Comprehensive phylogenetic analyses showed that five of the viruses belong to sub-genotype VI1.2.1.1.2.1 and 13 isolates belong to sub-genotype VI.2.1.1.2.2. The results demonstrate that these sub-genotypes have been predominant in China during the last decade. The viruses of these sub-genotypes have been independently maintained and continuously evolved for over 20 years, and differ significantly from those causing outbreaks worldwide during the 1980s to 2010s. The viral reservoir remains unknown and possibilities of the viruses being maintained in both pigeon farms and wild bird populations are viable. In vivo characterization of the isolates’ pathogenicity estimated mean death times between 62 and 114 h and intracerebral pathogenicity indices between 0.00 and 0.63. Cross-reactivity testing showed minor antigenic differences between the studied viruses and the genotype II LaSota vaccine. These data will facilitate PPMV-1 epidemiology studies, vaccine development, and control of Newcastle disease in pigeons and poultry.

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Section: Introductionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Complete Genome Sequencing, Molecular Epidemiological, and Pathogenicity Analysis of Pigeon Paramyxoviruses Type 1 Isolated in Guangxi, China during 2012–2018

Dimitrov³

et al. 2020

Viruses

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“…The tree was reconstructed based on the complete F gene (1-1662 nt) sequence using the IQ-TREE software, implemented by the GTR + F + I + G4 model with 1000 bootstrap replicates, using the genotype II NDV strain LaSota as the outgroup.Viruses 2020, 12, 433 6 of 16 Viruses 2020, 12, x FOR PEER REVIEW 6 of Distribution of VI.2.1.1.2.2 pigeon paramyxovirus type 1 (PPMV-1) isolated from China. The Chinese provinces where the presence of VI.2.1.1.2.2 PPMV-1 has been reported are indicated in red.All data were obtained from GenBank in NCBI[37].…”

mentioning

confidence: 99%

“…Distribution of VI.2.1.1.2.2 pigeon paramyxovirus type 1 (PPMV-1) isolated from China. The Chinese provinces where the presence of VI.2.1.1.2.2 PPMV-1 has been reported are indicated in red.All data were obtained from GenBank in NCBI[37].…”

mentioning

confidence: 99%

Evolutionary Dynamics and Age-Dependent Pathogenesis of Sub-Genotype VI.2.1.1.2.2 PPMV-1 in Pigeons

Xie

Chen

Zhang

et al. 2020

Viruses

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Pigeon paramyxovirus type 1 (PPMV-1) infection causes high morbidity in pigeons, resulting in a significant burden to the poultry industry. In this study, we isolated three PPMV-1 strains from diseased pigeons collected in Guangdong Province, South China, from June 2017 to April 2019. Genetic analysis revealed that these three PPMV-1 strains and most of the PPMV-1 strains isolated from China after 2011 were clustered into sub-genotype VI.2.1.1.2.2. Our Bayesian analysis revealed that the VI.2.1.1.2.2 viruses might have originated in Europe. Phylogeographic analyses revealed that East and South China might have played a key role in seeding the VI.2.1.1.2.2 PPMV-1 epidemic in China. To characterize the effect of age at infection on the outcome of PPMV-1 infection in pigeons, we investigated the pathogenesis and transmission of the pigeon/Guangdong/GZ08/2017 (GZ08) virus in 3-, 6-, and 12-week-old pigeons. Two of six 12-week-old pigeons inoculated with GZ08 survived, and all of the 3- and 6-week-pigeons inoculated with GZ08 died. Moreover, the GZ08 virus could be transmitted to 3-, 6-, and 12-week-old naïve contact pigeons. The lethality of the GZ08 virus through contact with 3-, 6-, and 12-week-old pigeons was 100%, 66.7%, and 0%, respectively, suggesting that the transmissibility of the GZ08 virus was stronger in young pigeons. These findings demonstrated that East and South China was the epicenter for dissemination of VI.2.1.1.2.2 PPMV-1, and age at infection has an impact on the outcome of PPMV-1 infection in pigeons.

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“…With the rapid development of China's social economy and the continuous improvement in people's quality of life in recent years, the pigeon industry has also developed rapidly, but the epidemic situation of diseases caused by PPMV-1 is not optimistic. Since its first isolation in China in the 1980s, PPMV-1 has long been prevalent in numerous provinces and regions of China, seriously impeding the development of the pigeon industry (23)(24)(25)(26)(27). As a result, it is critical to strengthen the epidemiological surveillance of PPMV-1 in China.…”

Section: Introductionmentioning

confidence: 99%

Biological Characterization and Evolutionary Dynamics of Pigeon Paramyxovirus Type 1 in China

Zhan

Lü

et al. 2021

Front. Vet. Sci.

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Pigeon paramyxovirus type 1 (PPMV-1) is considered as an antigenic variant of Newcastle disease virus (NDV) which has an obvious host preference for pigeons and has caused significant economic losses to the global poultry industry. The evolutionary dynamics of PPMV-1 in China, however, are poorly understood. In this study, we characterized seven PPMV-1 isolates from diseased pigeons collected in Jiangsu, Anhui, and Henan provinces during 2020. Phylogenetic analysis revealed that seven isolates belonged to sub-genotype VI.2.1.1.2.2. Biological characterization indicated that seven isolates were mesogenic based on the mean death time (69.6–91.2 h) and intracerebral pathogenicity index (1.19–1.40) and had similar growth kinetics in chicken embryos and CEFs. Furthermore, the four representative viruses (AH/01/20/Pi, JS/06/20/Pi, HN/01/20/Pi, and HN/02/20/Pi) could result in marked cytopathic effects (CPE) in CEFs and induced syncytium formation in Vero cells. Our Bayesian phylogenetic analysis showed that PPMV-1 might first emerge in East China in 1974 and East China had the highest genotypic diversity of PPMV-1. Besides, phylogeographic analysis indicated that East China and South China were probably the major epicenters of dissemination of PPMV-1 in China. Selection pressure analysis and amino acid substitutions analysis revealed that the viral replication complex (NP, P, and L proteins) was likely related with the host preference of PPMV-1. Collectively, this study uncovered the epidemiology and evolutionary dynamics of PPMV-1 circulating in China, emphasizing the importance of strengthening the monitoring of PPMV-1 in East China and South China and providing significant clues for further studies on the molecular mechanism underlying host preference of PPMV-1.

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Molecular characterization of two novel sub-sublineages of pigeon paramyxovirus type 1 in China

Cited by 8 publications

References 46 publications

Complete Genome Sequencing, Molecular Epidemiological, and Pathogenicity Analysis of Pigeon Paramyxoviruses Type 1 Isolated in Guangxi, China during 2012–2018

Complete Genome Sequencing, Molecular Epidemiological, and Pathogenicity Analysis of Pigeon Paramyxoviruses Type 1 Isolated in Guangxi, China during 2012–2018

Evolutionary Dynamics and Age-Dependent Pathogenesis of Sub-Genotype VI.2.1.1.2.2 PPMV-1 in Pigeons

Biological Characterization and Evolutionary Dynamics of Pigeon Paramyxovirus Type 1 in China

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