Molecular characterization of two host–guest associating hyaluronan derivatives

Šoltés, Ladislav; Mendichi, Raniero

doi:10.1002/bmc.252

Cited by 24 publications

(2 citation statements)

References 23 publications

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“…[46] Under inflammatory conditions of arthritic diseases, such as OA or RA, HMW HA is degraded by ROS, which reduces its viscosity and impairs its lubricant and shock absorbing properties, leading to deteriorated joint movement and pain. [47] It has been speculated that the removal of pathologic osteoarthritic SF and its replacement with HA-based products (viscosupplementation) may have beneficial therapeutic effects (section 2.3). [48]…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Intra-Articular Injections for the Treatment of Osteoarthritis

2011

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Osteoarthritis (OA), also called degenerative joint disease, is the most frequently occurring chronic musculoskeletal disease, particularly affecting the aging population. The use of viscosupplementation, i.e. intra-articular (IA) hyaluronic acid (HA) drug therapy, to treat OA, is growing worldwide, due to important results obtained from several clinical trials, which reported IA HA-related improvements in functional activity and pain management. This review is an update of the IA use of this compound in the treatment of OA, with clinical evidence from the last few years being discussed and used to delineate new trends for the future.

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Section: Hyaluronic Acidmentioning

confidence: 99%

Intra-Articular Injections for the Treatment of Osteoarthritis

2011

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“…As highlighted by Solte `s et al, such host-guest associating HA derivatives can be classified as a novel potential in the viscosupplementation of (osteo)arthritic joints [38]. This therapeutical concept consists in intraarticular injection of HA in order to compensate the loss of viscoelastic properties of endogeneous HA.…”

Section: Specific Interaction In Modified Charged Polysaccharide Systemsmentioning

confidence: 99%

Self-assembling polysaccharide systems based on cyclodextrin complexation: Synthesis, properties and potential applications in the biomaterials field

Auzély‐Velty

2010

Comptes Rendus. Chimie

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The supramolecular assemblies based on polysaccharides modified by cyclodextrins (CDs) and/or hydrophobic guest molecules have inspired interesting developments in the biomedical, pharmaceutical and cosmetic fields. This review will update the recent progress in the design, synthesis and study of such supramolecular structures. Preliminary studies demonstrated that such systems, based on the physical cross-linking of biopolymers through CD inclusion complexation, have potential as injectable hydrogels for the controlled release of drugs. Their nanoscale association also lead to the formation of original particles and films which pave the way to new applications in drug delivery and tissue engineering.

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Carbohydrates

Dräger

Krause

Möller

et al. 2011

Handbook of Biodegradable Polymers

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7 156 7 Carbohydrates AlginateAlginate belongs to the family of linear (unbranched), nonrepeating copolymers. It consists of variable amounts of βd -mannuronic acid (M) and its C5 -epimer α -lguluronic acid (G) which are linked via β -(1,4) -glycosidic bonds. The glycosidic bonds of mannuronic acid are connected to the following unit by a diequatorial 4 C 1 linkage, while guluronic acids are diaxial 1 C 4 linked. Alginate can be regarded as a true block copolymer composed of homopolymeric M and G regions, called M -and G -blocks, respectively, interspersed with regions of alternating structure [5] (Scheme 7.1 ).The physicochemical properties of alginate have been found to be highly affected by the M/G ratio as well as by the structure of the alternating zones. In terms of specifi c medical applications, alginate materials with a high guluronic acid ratio exhibit a much better compatibility [6] . The fi rst protocol to hydrolyze the glycosidic bonds of alginate has been published by Haug et al. in the 1960s and is based on a pH -dependent acid -catalyzed hydrolysis, which leads to a fragmentation of the polymeric chain. Breaking the glycosidic bonds of both building blocks selectively could be achieved due to different p K a values of mannuronic acid (p K a : 3.38) and guluronic acid (p K a : 3.65) [7] . Therefore, polyguluronic acid can be separated by precipitation in aqueous conditions after protonating the carboxyl groups.Alginate can be extracted from marine brown algae or it can be produced by bacteria. Both species produce alginate as an exopolymeric polysaccharide during their growth phase. Isolated alginates from marine brown algae like Laminaria hyperborea or lessonia , gained by harvesting brown seaweeds from coastal regions, tend to vary in their constitution due to seasonal and environmental changes. Like chitin in shellfi sh, alginates in algae have structure -forming functions. This is due to the intracellular formed gel matrix, which is responsible for mechanical strength, fl exibility, and form. Alginates in bacteria are synthesized only by two genera, Pseudomonas and Azotobacter , and have been extensively studied over the last 40 years. While primarily synthesized in the form of polymannuronic acid, the biosynthesis undergoes chemical modifi cations comprising acetylation and epimerization, which occurs during periplasmic transfer and before fi nal export through the outer membrane. Extracted alginate from Pseudomonas contains only M blocks Scheme 7.1 Chemical structure of alginate with mannuronic acid (M), alternating, and guluronic acid (G) blocks.

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Molecular characterization of two host–guest associating hyaluronan derivatives

Cited by 24 publications

References 23 publications

Intra-Articular Injections for the Treatment of Osteoarthritis

Intra-Articular Injections for the Treatment of Osteoarthritis

Self-assembling polysaccharide systems based on cyclodextrin complexation: Synthesis, properties and potential applications in the biomaterials field

Carbohydrates

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