Molecular characterization of toxicity mechanism of single-walled carbon nanotubes

A real-time documentation and mechanistic investigation of quantum dots-induced autophagy in live Caenorhabditis elegans

“…The chronic toxicity (e.g. retarded growth) of amide-modified singlewalled carbon nanotubes (a-SWCNTs) for C. elegans is also reported by Chou et al Combined with their results of functional genomic study and endocytosis marker labeling study, they have concluded that the endocytosis of intestinal cells of a-SWCNTs treated worms is inhibited, which may have been an important mechanism in aSWCNTs toxicity [46]. Therefore, comparing with other animal models, C. elegans have the capability of providing the real-time toxicity information of nanomaterials at molecular level, subcellular level and whole-organism level simultaneously, and then helping researchers to draw more relevant conclusions for the biosafety of nanomaterials.…”

Toxicity evaluation of boron nitride nanospheres and water-soluble boron nitride in <em>Caenorhabditis elegans</em>

“…Given that ROS production indicates the toxicity of nanobiomaterials, eg, GO, 28 CNTs, 26 TiO 2 , and ZnO, 36,40 our data here suggest that ROS overproduction in the intestine tissue might be one of the mechanisms underlying adverse BNNS and BN-800-2 effects.…”

“…[19][20][21] These NMs include metal nanoparticles (NPs; TiO 2 , Al 2 O 3 , and ZnO 2 ) [22][23][24] and carbon NPs (carbon NTs [CNTs], graphene oxide [GO], and graphite nanoplatelets). [25][26][27][28] Here, we analyze the two aforementioned representative forms of BN NMs in C. elegans: BNNSs and BN-800-2. In this study, we examined the multiple phenotypic toxicities of two types of BN NMs with different morphology, size, and solubility using C. elegans in aqueous media.…”

A systems toxicology approach on the mechanism of uptake and toxicity of MWCNT in Caenorhabditis elegans

“…In a recently conducted microarray study of C. elegans exposed to amide-single wall carbon nanotube (SWCNT) [24], 14 up-and 2085 down-regulated genes were reported after exposure to L1 stage C. elegans at 500 mg/L for 48 h. In our study, 983 up-and 1267 down-regulated genes were observed for young adults exposed to 1 mg/L for 24 h. It is difficult to compare microarray result from independent experiments, as differences in DEGs may be influenced by differences in the specific biological systems, array platforms and statistical methods. The number of up-regulated genes was much higher in our study as compared to that in the SWCNT study [24], which may be due to the fact that our exposure conditions reflected a relatively mild stress response, whereas the exposure conditions of the SWCNT study induced a much more severe stress responses, which was more likely to lead to transcriptional shut-down.…”