“…Age of the sample was expressed as mean ± SD in 10 trials (10/29, 34%) [18,19,20,21,22,23, 27, 28, 33, 34, 38] in which mean age ranged from 36 ± 3 to 60 ± 17 [27, 38]. In 18 trials (18/29, 62%) that presented an age range [5,6,7,8,9,10,12,13,14,15,16,17,24,25,26,29,30,31,32,35,36,37], the youngest and eldest patients enrolled were 19 years [24,25,26] and 84 years [12], respectively.…”