Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor

Abstract

Context.— Mesothelioma of the tunica vaginalis testis (TVT) is an extremely rare form of mesothelioma. Objective.— To compare the clinical and molecular characteristics of mesothelioma of the TVT with those of mesothelioma at other more common sites, including the relationship with exposure to asbestos. Design.— We present clinical and pathological data for 9 cases of primary TVT mesothelioma. We performed whole-genome sequencing on 3 cases for the first time. Results.— The majority (7 of 9 cases) of TVT mesotheliomas were epithelioid, with the remaining 2 cases showing biphasic morphology. Morphology and immunohistochemical profiles were indistinguishable from mesothelioma elsewhere. Asbestos exposure was documented for 7 of the 9 cases, with no information for 2 cases. The 3 TVT mesothelioma cases that underwent whole-genome sequencing displayed a mutational profile similar to that of mesothelioma at other sites, including NF2 and TP53 mutations. Conclusions.— The clinical and molecular profile of TVT mesothelioma is similar to that of mesothelioma elsewhere.

Mesothelioma in the pleura, pericardium and peritoneum: Recommendations from the International Collaboration on Cancer Reporting (ICCR)

“…In line with the ever-expanding literature of clinically relevant molecular changes, the section on ancillary data and recommendation has been expanded, and will probably require expansion into the future. [91][92][93][94][95][96] Possibly most significantly, in-situ mesothelioma is now an accepted diagnostic category and is timely; as more data are collected on the clinical significance of this diagnosis, this will inform any updates of future UICC/AJCC staging manuals and, eventually, clinical trials.…”

Defense and Protection of the Marine Coastal Areas and Human Health: A Case Study of Asbestos Cement Contamination (Italy)

“…The fracture and size (length and diameter) of the asbestos fibers [18] represent the most crucial parameters of their toxicity [19]. These features make these minerals highly carcinogenic and responsible for uncommon, dangerous diseases, including asbestosis, tumors in the lung [20,21], larynx and ovaries, mesothelioma, a rare malignancy of the serosal membranes [15], and serous covering of the testis [22]. Mesothelioma is commonly associated with prior extensive inhalation of crocidolite [23], tremolite, and amosite fibers, but other fibrous minerals (such as erionite, fluoro-edenite, and balangeroite) [24] can also be responsible for this disease.…”

Mesothelioma of the tunica vaginalis testis

“…et tilfaelde/år i Danmark. Mulige risikofaktorer for udvikling af MTVT omfatter asbesteksposition og tidligere hydrocele [4].…”

“…Nye data tyder på, at MTVT ligner de pleurale og peritoneale mesoteliomer vedrørende morfologiske undertyper og genomiske forandringer [4]. I Danmark foregår den onkologiske del af behandlingen på Rigshospitalet, hvor en opgørelse i 2023 fandt i alt otte patienter i løbet af de seneste ti år [5].…”