2013
DOI: 10.1016/j.jped.2012.11.002
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Molecular characterization of rotavirus genotypes in immunosuppressed and non-immunosuppressed pediatric patients

Abstract: RVA infections can be associated with severe clinical manifestations, and the surveillance of genotypic variability of this virus is crucial to monitor the emergence of new strains and the impact of the immunization in these patients.

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Cited by 4 publications
(5 citation statements)
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“…Gastroenteritis and diarrhea caused by rotavirus infections pose a significant threat to especially the health of newborns and immunosuppressed in low- and middle income countries [54, 55]. The rotavirus vaccine for infants recommended by WHO in 2013 has the potential to counter that danger but until a herd effect is reached [56], RV remains one of the most relevant waterborne enteric viruses.…”
Section: Discussionmentioning
confidence: 99%
“…Gastroenteritis and diarrhea caused by rotavirus infections pose a significant threat to especially the health of newborns and immunosuppressed in low- and middle income countries [54, 55]. The rotavirus vaccine for infants recommended by WHO in 2013 has the potential to counter that danger but until a herd effect is reached [56], RV remains one of the most relevant waterborne enteric viruses.…”
Section: Discussionmentioning
confidence: 99%
“…However, diarrhoea still represents a frequent cause of hospitalisation and, except for RVA, the role of other enteric viruses was not determined in our patients and their incidence was likely underestimated. Previously, we have carried out RV genotypic characterisation in all positive samples and G2 P[4] was the most prevalent genotype after the vaccine implementation in 2006 (Pereira et al 2013). …”
Section: Discussionmentioning
confidence: 99%
“… 35 São Paulo 2006 - 2009 G9P[8] – dominant type in 2006 G2P[4] – dominant type in 2007 / 2008 / 2009 Cilli et al 11 São Paulo 2006 - 2008 In hospitalized children: G2P[4] - 15% (2006) / 70% (2007) / 100% (2008) Sáfadi et al 36 Belém 2008 - 2009 In hospitalized children: G2P[4] predominance Justino et al 37 Minas Gerais 2009 - 2010 G2P[4] predominance Dulgheroff et al. 38 Curitiba 2001 - 2008 In hospitalized patients: G2P[4] predominance after 2006 Pereira et al 39 18 Brazilian states 2005 - 2009 G9 – dominant type in 2005 (52%) G2P[4] – 49% (2006) / 66% (2007) / 85% (2008) / 37%(2009) Carvalho-Costa et al. 6 Australia 2007 - 2009 Increase in G2P[4] rates in most states where Rotarix® is in use Kirkwood et al 40 …”
Section: Resultsmentioning
confidence: 99%