Molecular Characterization of MCR-1 Producing Enterobacterales Isolated in Poultry Farms in the United Arab Emirates

Sonnevend, Ágnes; Alali, Walid Q.; Mahmoud, Sara; Ghazawi, Akela; Bharathan, Greeshma; Melegh, Szilvia; Rizvi, Tahir A.; Pál, Tibor

doi:10.3390/antibiotics11030305

Cited by 13 publications

(11 citation statements)

References 49 publications

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“…It should be noted that during the study period (i.e., 2009–2015), in the absence of clear technical guidelines, several laboratories either used the unreliable disk diffusion or automated susceptibility testing methods or did not test for colistin susceptibility, likely contributing to the excessive use of this drug. Although the presence of transferable colistin resistance genes was not studied in the current project, previous observations suggest that, while common among animal isolates [ 25 ], plasmid-mediated colistin resistance is either absent or relatively rare among clinical isolates in the region [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Early Years of Carbapenem-Resistant Enterobacterales Epidemic in Abu Dhabi

et al. 2022

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Recent studies showed that the current endemic of carbapenem-resistant Enterobacterales (CRE) in the Emirate of Abu Dhabi is dominated by highly resistant Klebsiella pneumoniae clones ST14, ST231, and CC147, respectively. In the absence of continuous, molecular typing-based surveillance, it remained unknown whether they lately emerged and rapidly became dominant, or they had been present from the early years of the endemic. Therefore, antibiotic resistance, the presence of carbapenemase and 16S methylase genes, and the sequence types of CRE strains collected between 2009 and 2015 were compared with those collected between 2018 and 2019. It was found that members of these three clones, particularly those of the most prevalent ST14, started dominating already in the very early years of the CRE outbreak. Furthermore, while severely impacting the overall antibiotic resistance patterns, the effect of these clones was not exclusive: for example, increasing trends of colistin or decreasing rates of tigecycline resistance were also observed among nonclonal isolates. The gradually increasing prevalence of few major, currently dominating clones raises the possibility that timely, systematic, molecular typing-based surveillance could have provided tools to public health authorities for an early interference with the escalation of the local CRE epidemic.

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Section: Discussionmentioning

confidence: 99%

Early Years of Carbapenem-Resistant Enterobacterales Epidemic in Abu Dhabi

et al. 2022

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“…Sonnevend et al investigating MCR-producing Enterobacterales of animal origin from fecal samples of poultry collected in four farms in the United Arab Emirates. The study revealed that mcr-1 positive strains were identified in 36 of the 40 samples Current Situation of Escherichia coli Antibiotic Resistance in Food-producing Animals, Wild… DOI: http://dx.doi.org/10.5772/intechopen.108896 (90%) [49]. Thirty-four multi-drug resistant E. coli of 16 different sequence types, two Escherichia albertii, two Klebsiella pneumoniae, and one Salmonella minnesota were identified [49].…”

Section: Current Situation Of E Coli Antibiotic Resistance In Food-pr...mentioning

confidence: 99%

“…The study revealed that mcr-1 positive strains were identified in 36 of the 40 samples Current Situation of Escherichia coli Antibiotic Resistance in Food-producing Animals, Wild… DOI: http://dx.doi.org/10.5772/intechopen.108896 (90%) [49]. Thirty-four multi-drug resistant E. coli of 16 different sequence types, two Escherichia albertii, two Klebsiella pneumoniae, and one Salmonella minnesota were identified [49]. Beyond various aminoglycoside, tetracycline, and cotrimoxazole resistance genes, seven of them also carried ESBL genes and one blaCMY-2.…”

Section: Current Situation Of E Coli Antibiotic Resistance In Food-pr...mentioning

confidence: 99%

“…In the case of the IncHI2 plasmids co-transferring ampicillin, chloramphenicol, and tetracycline resistance. The author commented that the diversity of mcr-1 positive strains suggest a complex local epidemiology calling for coordinated surveillance including animals, retail meat, and clinical cases [49].…”

Section: Current Situation Of E Coli Antibiotic Resistance In Food-pr...mentioning

confidence: 99%

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Current Situation of Escherichia coli Antibiotic Resistance in Food-producing Animals, Wild Animals, Companion Animals, and Birds: One Health Perspectives

Ishag¹,

Abdelwahab²,

Hammadi³

et al. 2022

Escherichia Coli Infections - An Update [Working Title]

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Escherichia coli (E. coli) has shown antimicrobial resistance (AMR) to a range of antibiotics, including the last resort antibiotics, which represent a global burden. Thus, it is essential to consider the AMR from a One Health perspective due to the ability of antimicrobial resistance to be transmitted between animals and humans share the same environment. As a result, and to minimize the emergence and spread of the AMR requires coordination in the multi-sectorial effort. However, in most cases, animals and birds have been ignored by public health authorities while antimicrobial resistance is being reported. This gap poses a serious public health burden due to the close contact between food-producing animals, companion animals, or companion birds, humans, and their environment. Therefore, this chapter aims to highlight the current situation of E. coli AMR in food-producing animals, wild animals, companion animals, and birds from One Health perspective. In conclusion, the chapter shows that E. coli exerted resistance to a range of antibiosis, including the last resort of antibiotics in livestock and birds worldwide which calls for joint efforts under one health umbrella to address the challenge of E. coli AMR in animals and birds.

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“…Escherichia albertii also has been detected in poultry faeces/GI tract contents and meat (e.g. (8,(23)(24)(25) and in domestic mammals (e.g. pig, cat) and both terrestrial and marine wild mammal species (e.g.…”

Section: Introductionmentioning

confidence: 99%

The genomic epidemiology of Escherichia albertii

Bengtsson

Baker

Cunningham

et al. 2022

Preprint

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Escherichia albertii is a recently identi ed gastrointestinal bacterial pathogen of humans and animals which is typically misidenti ed and generally only detected during genomic surveillance of other Enterobacteriaceae. The incidence of E. albertii is likely underestimated and its epidemiology and clinical relevance are poorly characterised. Here, we whole genome sequenced E. albertii isolates from humans (n = 83) and birds (n = 79) in Great Britain and analysed a broader public dataset (n = 475) to address these gaps. We found human and avian isolates typically (90%; 148/164) belonged to host-associated monophyletic groups with distinct virulence and antimicrobial resistance pro les. Overlaid patient epidemiological data suggested that human infection was likely related to travel and possibly foodborne transmission. The Shiga toxin encoding stx2f gene was associated with clinical disease (OR = 10.27, 95% CI = 2.98-35.45 p = 0.0002) in nches. Our results suggest that improved future surveillance will further elucidate disease ecology and public and animal health risks associated with E. albertii.

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Molecular Characterization of MCR-1 Producing Enterobacterales Isolated in Poultry Farms in the United Arab Emirates

Cited by 13 publications

References 49 publications

Early Years of Carbapenem-Resistant Enterobacterales Epidemic in Abu Dhabi

Early Years of Carbapenem-Resistant Enterobacterales Epidemic in Abu Dhabi

Current Situation of Escherichia coli Antibiotic Resistance in Food-producing Animals, Wild Animals, Companion Animals, and Birds: One Health Perspectives

The genomic epidemiology of Escherichia albertii

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