Molecular characterization of <i>Schistosoma</i> infections in African migrants: identification of a <i>Schistosoma haematobium-bovis</i> hybrid in bladder biopsies

Marascio, Nadia; Loria, Maria Teresa; Lamberti, Angelo Giuseppe; Pavia, Grazia; Adams, Neill James; Quirino, Angela; Divenuto, Francesca; Mazzitelli, Maria; Greco, G.; Trecarichi, Enrico Maria; Perandin, Francesca; Bisoffi, Zeno; Webster, Bonnie L.; Liberto, Maria Carla; Torti, Carlo; Matera, Giovanni

doi:10.1093/jtm/taab194

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…In recent decades, clinically significant hybrid species have been discovered with increasing frequency. Hybridisation between human and animal pathogenic species poses a potential threat due to the easier transmission and spread of new strains [ 24 ]. This could potentially render current control measures ineffective.…”

Section: Epidemiologymentioning

confidence: 99%

“…The miracids metamorphose inside the mollusc into cercariae, the form that infects humans (or other mammals) by penetrating the skin. The cercariae are attracted to hydrocarbons and fatty acids present on the epidermal surface [ 13 , 24 ]. Schistosomula develop into adult worms after the parasite enters the final host through the skin and travels through the bloodstream to the liver ( Fig.…”

Section: Life Cyclementioning

confidence: 99%

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Insights into the epidemiology, pathogenesis, and differential diagnosis of schistosomiasis

Ponzo,

Midiri,

Manno

et al. 2024

EuJMI

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Schistosomiasis is a neglected tropical disease that is prevalent in low- and middle-income countries. There are five human pathogenic species, of which Schistosoma haematobium, Schistosoma mansoni and Schistosoma japonicum are the most prevalent worldwide and cause the greatest burden of disease in terms of mortality and morbidity. In addition, hybrid schistosomes have been identified through molecular analysis. Human infection occurs when cercariae, the larval form of the parasite, penetrate the skin of people while bathing in contaminated waters such as lakes and rivers. Schistosomiasis can cause both urogenital and intestinal symptoms. Urogenital symptoms include haematuria, bladder fibrosis, kidney damage, and an increased risk of bladder cancer. Intestinal symptoms may include abdominal pain, sometimes accompanied by diarrhoea and blood in the stool. Schistosomiasis affects more than 250 million people and causes approximately 70 million Disability-Adjusted Life Years (DALYs), mainly in Africa, South America, and Asia. To control infection, it is essential to establish sensitive and specific diagnostic tests for epidemiological surveillance and morbidity reduction. This review provides an overview of schistosomiasis, with a focus on available diagnostic tools for Schistosoma spp. Current molecular detection methods and progress in the development of new diagnostics for schistosomiasis infection are also discussed.

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Section: Epidemiologymentioning

confidence: 99%

Section: Life Cyclementioning

confidence: 99%

Insights into the epidemiology, pathogenesis, and differential diagnosis of schistosomiasis

Ponzo,

Midiri,

Manno

et al. 2024

EuJMI

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“…Six main species of Schistosoma are responsible for infection in humans: S. mansoni , S. haematobium , S. japonucum , S. intercalatum , S. guineensis , and S. mekongi , with S. haematobium and S. mansoni , being the most widespread. There have also been reports of human infection with hybrid species involving S. haematobium - bovis and S. curassoni - matthei (from cattle) in humans [ 5 , 6 , 7 ]. Schistosoma infection is often acquired during childhood due to frequent contact with infected freshwater and chronic illness usually develops in adults [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of IL-35, as a Possible Biomarker for Follow-Up after Therapy, in Chronic Human Schistosoma Infection

et al. 2023

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The host response to helminth infections is characterized by systemic and tissue-related immune responses that play a crucial role in pathological diseases. Recently, experimental studies have highlighted the role of regulatory T (Tregs) and B (Bregs) cells with secreted cytokines as important markers in anti-schistosomiasis immunity. We investigated the serical levels of five cytokines (TNFα, IFN-γ, IL-4, IL-10 and IL-35) in pre- and post-treatment samples from chronic Schistosoma infected patients to identify potential serological markers during follow-up therapy. Interestingly, we highlighted an increased serum level of IL-35 in the pre-therapy samples (median 439 pg/mL for Schistosoma haematobium and 100.5 pg/mL for Schistsoma mansoni infected patients) compared to a control group (median 62 pg/mL and 58 pg/mL, respectively, p ≤ 0.05), and a significantly lower concentration in post-therapy samples (181 pg/mL for S. haematobium and 49.5 pg/mL for S. mansoni infected patients, p ≤ 0.05). The present study suggests the possible role of IL-35 as a novel serological biomarker in the evaluation of Schistosoma therapy follow-up.

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Molecular characterization of Schistosoma infections in African migrants: identification of a Schistosoma haematobium-bovis hybrid in bladder biopsies

Cited by 2 publications

References 8 publications

Insights into the epidemiology, pathogenesis, and differential diagnosis of schistosomiasis

Insights into the epidemiology, pathogenesis, and differential diagnosis of schistosomiasis

Evaluation of IL-35, as a Possible Biomarker for Follow-Up after Therapy, in Chronic Human Schistosoma Infection

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