Molecular Characterization of Human Neogenin, a DCC-Related Protein, and the Mapping of Its Gene (NEO1) to Chromosomal Position 15q22.3–q23

Interaction of Myc-Associated Zinc Finger Protein with DCC, the Product of a Tumor-Suppressor Gene, during the Neural Differentiation of P19 EC Cells

“…5D and 5E). The conserved regions of DCC from human, rat, mouse and Xenopus (3, 10, 11, 39) exhibited considerable homology to other membrane proteins, such as neogenin (40,41) and Frazzled protein (42), in particular in the case of the P3 domain. The cytoplasmic domain of DCC protein has three regions conserved across species, named P1, P2 and P3 (18,42).…”

New cell surface markers for murine fetal hepatic stem cells identified through high density complementary DNA microarrays

“…33 It is also reported to be expressed during transition of undifferentiated into differentiated cell types. 34 Interestingly, EfnB3 and roundabout homolog 1 (Robo1), surface markers within FLSPC-up genes, have also been reported to be involved in axon guidance, and in developing endodermal tissues. EfnB3 has been identified recently in the developing mouse pancreas and is thought to be essential for the differentiation and migration patterning of different specialized cell subtypes.…”

Genome-wide expression profiling of 8-chloroadenosine- and 8-chloro-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray

“…Connexin 26 is expressed in normal human mammary epithelial cells but not in mammary tumor cell lines (Lee et al, 1992), and has an essential role during an early stage of murine development (Gabriel et al, 1998). Neogenin is a tumor suppressor gene DCCrelated protein, and believed to be involved in early differentiation of nervous system (Vielmetter et al, 1997). Neurofilament triplet L protein is the component of neuronal cytoskeleton found in neurons of both the central and peripheral nervous systems (Carpenter and Wallace, 1996), and the up-regulation of its expression can be regarded as evidence of differentiation or reverse transformation of neuronal cells.…”