Molecular characterization of epstein‐barr virus and oncoprotein expression in nasopharyngeal carcinoma in Korea

Abstract

EBV type and LMP1 variant had no significant influence on the clinicopathologic properties of tumor. However, there was a tendency toward a better survival in the EBV type B group. Histology and clinical staging were the two most important prognostic factors.

Difference of Epstein–Barr virus isolates from Japanese patients and African Burkitt’s lymphoma cell lines based on the sequence of latent membrane protein 1

“…1), while only low values are found from Caucasian origin in comparison to Mongoloid origin [32][33][34]. It was dominantly detected in areas where Mongoloids reside such as Japan [11,12] and China [33], Korea [28,35], Taiwan [36], Malaysia [26,37], Brazil [38,39], and in ethnic groups along the Arctic Circle (Inuit) [33]. On the other hand, the high ratio of 30-bp deletion is not always detected in areas in which Mongoloids are distributed with a high frequency.…”

“…Numerous studies have been made based on its deletion [10][11][12]26]. The 30-bp deletion mutant in the C-terminal region of the LMP1 gene has been reported to have a strong potential to transform rodent cell and B-lymphocyte and it was also found to be closely associated with NPC [26][27][28]. The 30-bp sequence in C-terminus of LMP1 is thus suggested to play an important role in the process of oncogenesis [10].…”

LMP1 expression is positively associated with metastasis of nasopharyngeal carcinoma: evidence from a meta-analysis

“…As for overlapping data from the same researchers, we contacted the authors and discussed with them to reach an agreement about what data should be collected and what data should be taken away, or just selected the ones with the maximum number of cases. After the initial search, we reviewed the title, abstract and text of all 55 papers carefully in accordance with the criteria above, and finally selected 12 articles for further analysis 1 11 15 16 18–25…”

“…Although several clinical case studies with a small sample size provided evidence to support the laboratory-derived opinion that LMP1 is related to NPC invasion and metastasis, there are no large-scale studies or meta-analyses on this issue to substantiate the view so far. Moreover, some clinical studies argued that LMP1 is not associated with NPC invasion and metastasis 11 15 16. Therefore, it is not yet clear whether LMP1 plays a role in NPC invasion and metastasis.…”

Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9

“…Many proteolytic enzymes such as matrix metalloproteinase (MMPs) and serine proteinases are involved in tumor host interactions for degradation of the underlying basement membrane (16,17). MMPs are produced by cancer cells and several reports have shown that elevated expression of MMP appears to be related to the invasion and aggressiveness (18,19). MMP-2 and MMP-9 both are recognized to play an important role in cancer cell invasion which may due to their ability to cleave the type IV collagen (20).…”