Molecular characterization of different fusion oncogenes associated with childhood Acute Lymphoblastic leukaemia from Pakistan

Faiz, Mariam; Qureshi, Asif M. Iqbal; Qazi, Javed Iqbal

doi:10.5455/ijavms.20110905093504

Cited by 3 publications

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“…The frequency of some of the FO in this study is comparable to the previous studies from Pakistan and other parts of the world (Gaynon et al, 1997;Iacobucci et al, 2012). A strikingly high frequency of BCR-ABL FO was found in this study which is in keeping with the previous reports from Pakistan Tanveer, 2006, Iqbal et al, 2007;Faiz et al, 2011).…”

Section: Discussionsupporting

confidence: 92%

“…Therefore, the distribution of genetic and molecular subtypes may not be uniform in different parts of the world (Romana., 1995;Ariffin et al, 2007). Moreover, gene-environment interactions, which are critical in leukemogenesis, may differently contribute in defining the relative proportions of molecular subgroups in different geographic regions (Iqbal et al, 2006;Siddique et al, 2010;Faiz et al, 2011;Schmiegelow et al, 2012;Schrappe et al, 2012). The most common oncogenes found in leukemia patients are the fusion genes, which are formed as a result of different genetic abnormalities at the chromosomal level (Zelent et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

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Five Most Common Prognostically Important Fusion Oncogenes are Detected in the Majority of Pakistani Pediatric Acute Lymphoblastic Leukemia Patients and are Strongly Associated with Disease Biology and Treatment Outcome

Awan

Iqbal²,

Aleem³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Five Most Common Prognostically Important Fusion Oncogenes are Detected in the Majority of Pakistani Pediatric Acute Lymphoblastic Leukemia Patients and are Strongly Associated with Disease Biology and Treatment Outcome

Awan

Iqbal²,

Aleem³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…After this DNA breakage usually, the repairs are imperfect result in the accumulation of mutations in the genes. These mutations cause drug resistance and rapid disease progesssion 16,17 [18][19][20] . Pandita showed higher results than the present study.…”

Section: B-lymphoblastic Leukemia (B-all) Is a Common Childhood Malig...mentioning

confidence: 99%

Frequency of BCR-ABL Gene Translocation in B-ALL Patients Associated with Clinicopathological Parameters

2022

PJMD

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Background: B-Acute Lymphoblastic Leukemia (B-ALL) accounts for 25% of childhood malignancies. Chromosomal abnormalities like translocations lead to the formation of oncogenes, some of which are strong predictors of prognosis and response to anti-leukemic therapy. This study aimed to find out the frequency of BCR-ABL gene translocation in B-ALL patients by fluorescence in situ hybridization (FISH) and its association with their clinicopathological parameters. Methods: Patients (n=150) aged 1-17 years with a confirmed diagnosis of B-ALL were selected. Peripheral blood and/or bone marrow aspirate samples were obtained and Breakpoint cluster region-Abelson murine leukemia viral oncogene (BCR-ABL) translocation by FISH was observed. The patient’s demographics, hemoglobin levels, total leucocytes count, platelet count, FISH results, CNS status and risk stratification were recorded. Data was stratified and the Chi-square test was applied, p-value < 0.05 was considered statistically significant. Results: There were 100 (66.67%) males and 50 (33.33%) females. The average age of the patients was 7.03±4.51 years. The frequency of BCR-ABL translocation in B-ALL was 16(10%). A significant association was found between age and BCR-ABL translocation (p-value <0.05), however, an insignificant association was recorded among gender, Hb levels, TLC, platelet count, CNS status, proposed risk stratification system of B-ALL and BCR-ABL translocation (p-value >0.05). Conclusion: The frequency of BCR-ABL translocation in B-ALL was significantly high in the targeted population. FISH improves detection of the BCR-ABL translocation in either metaphase or interphase cells. Therefore, BCR-ABL expression can be considered as a prognostic approach and assist in effective treatment planning and better management of these children. Keyword: Leukemia; In Situ Hybridization; Fluorescence; Pathology.

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Frequency of Three Different Gene Mutations (TEL-AML1, E2A-PBX1 and MLL-AF4) In Acute Lymphoblastic Leukaemia

Khan¹

2016

HTIJ

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Molecular characterization of different fusion oncogenes associated with childhood Acute Lymphoblastic leukaemia from Pakistan

Cited by 3 publications

References 0 publications

Five Most Common Prognostically Important Fusion Oncogenes are Detected in the Majority of Pakistani Pediatric Acute Lymphoblastic Leukemia Patients and are Strongly Associated with Disease Biology and Treatment Outcome

Five Most Common Prognostically Important Fusion Oncogenes are Detected in the Majority of Pakistani Pediatric Acute Lymphoblastic Leukemia Patients and are Strongly Associated with Disease Biology and Treatment Outcome

Frequency of BCR-ABL Gene Translocation in B-ALL Patients Associated with Clinicopathological Parameters

Frequency of Three Different Gene Mutations (TEL-AML1, E2A-PBX1 and MLL-AF4) In Acute Lymphoblastic Leukaemia

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