Molecular Characterization of Brazilian Infectious Bursal Disease Virus Isolated from 1997 to 2005

Fernandes, Maria Judite Bittencourt; Simoni, Isabela Cristina; Vogel, Maria Gabriela; Harakava, Ricardo; Rivas, Eliana Borges; Oliveira, Maria Beatriz C.; Kanashiro, Ana Maria Iba; Tessari, Eliana Neire Castiglioni; Gama, Nilce Maria Soares Queiroz; Arns, Clarice Weis

doi:10.1637/8531-112808-reg.1

Cited by 13 publications

(13 citation statements)

References 18 publications

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“…The reference vvIBDV strains have a glycine at 254, and we identified strains that contained either a serine or aspartic acid at this position. A G254D mutation was identified in samples from Russia, Kazakhstan, Jordan and Malaysia and has been reported in vvIBDV strains from Brazil [ 43 ]. Interestingly, the G254D mutation was found in Russian samples that all had an additional pair of mutations, S328K and S332N, located in the serine-rich heptapeptide region adjacent to the P HI loop [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Classification of infectious bursal disease virus into genogroups

2017

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Infectious bursal disease virus (IBDV) causes infectious bursal disease (IBD), an immunosuppressive disease of poultry. The current classification scheme of IBDV is confusing because it is based on antigenic types (variant and classical) as well as pathotypes. Many of the amino acid changes differentiating these various classifications are found in a hypervariable region of the capsid protein VP2 (hvVP2), the major host protective antigen. Data from this study were used to propose a new classification scheme for IBDV based solely on genogroups identified from phylogenetic analysis of the hvVP2 of strains worldwide. Seven major genogroups were identified, some of which are geographically restricted and others that have global dispersion, such as genogroup 1. Genogroup 2 viruses are predominately distributed in North America, while genogroup 3 viruses are most often identified on other continents. Additionally, we have identified a population of genogroup 3 vvIBDV isolates that have an amino acid change from alanine to threonine at position 222 while maintaining other residues conserved in this genogroup (I242, I256 and I294). A222T is an important mutation because amino acid 222 is located in the first of four surface loops of hvVP2. A similar shift from proline to threonine at 222 is believed to play a role in the significant antigenic change of the genogroup 2 IBDV strains, suggesting that antigenic drift may be occurring in genogroup 3, possibly in response to antigenic pressure from vaccination.Electronic supplementary materialThe online version of this article (doi:10.1007/s00705-017-3500-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Classification of infectious bursal disease virus into genogroups

2017

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“…W ostatnich latach zaobserwowano na świecie wzrost zakażeń IBDV w stadach szczepionych. Wywołujące te infekcje szczepy charakteryzowała obecność pojedynczych zmian aminokwasowych w obrębie mniejszych pików hydrofilowych (pętla P DE oraz P FG ) regionu hvVP2 (20,24,52). Ważność mutacji niesynonimicznych dla funkcjonowania wirusa IBD podkreślają badania z użyciem technik inżynierii genetycznej.…”

Section: Zmienność Genetyczna Ibdvunclassified

“…Podobną sytuację opisywano przy identyfikacji szczepów wysoce zjadli-wych w stadach szczepionych. Szczepy te posiadały w pozycji 254 serynę (S), kwas aspartowy (D) lub asparaginę (N), zaś szczepy szczepionkowe stosowane do immunizacji posiadały glicynę (G), co mogło pomóc w ominięciu przeciwciał neutralizujących i wystąpieniu choroby (24,72,83). Częste mutacje w sekwencji genu białka VP2 wskazują, że pewne kodony podlegają ciągłej presji ze strony środowiska, co może sprzyjać pojawianiu się mutacji zmieniających antygenowość wirusa.…”

Section: Zmienność Genetyczna Ibdvunclassified

Selected aspects of infectious bursal disease – the current state of knowledge

Pikuła

Śmietanka

2023

Medycyna Weterynaryjna

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Infectious bursal disease (IBD) is a highly infectious and contagious immunosuppressive viral disease of chickens with a worldwide economic significance to the poultry industry. Over fifty years have passed since the first confirmed occurrence of the disease, and the virus has spread all over world and evolved into multiple genetic, antigenic and pathotypic variants, becoming a serious threat to the poultry industry. The primary tool in IBD eradication is the maintenance of strict biosecurity in poultry farms and implementation of vaccination programmes which should take into account the current epidemiological knowledge about the IBDV strains circulating in the field. This review article presents the current state of knowledge about the infectious bursal disease virus (IBDV) with special regard to the molecular biology of the virus, immunological aspects, as well as current and future prevention strategies.

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“…This virus is widely vaccinated against in the larger Caribbean countries with established intensive poultry industries. Very virulent strains of IBDV (vvIBDV) have been reported to be circulating in South American countries, causing disease in vaccinated birds [ 47 , 48 , 49 ]…”

Section: Infectious Bursal Disease Virusmentioning

confidence: 99%

A Review of Eight High-Priority, Economically Important Viral Pathogens of Poultry within the Caribbean Region

Jordan

Gongora²,

Hartley

et al. 2018

Veterinary Sciences

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Viral pathogens cause devastating economic losses in poultry industries worldwide. The Caribbean region, which boasts some of the highest rates of poultry consumption in the world, is no exception. This review summarizes evidence for the circulation and spread of eight high-priority, economically important poultry viruses across the Caribbean region. Avian influenza virus (AIV), infectious bronchitis virus (IBV), Newcastle disease virus (NDV), infectious laryngotracheitis virus (ILTV), avian metapneumovirus (aMPV), infectious bursal disease virus (IBDV), fowl adenovirus group 1 (FADV Gp1), and egg drop syndrome virus (EDSV) were selected for review. This review of serological, molecular, and phylogenetic studies across Caribbean countries reveals evidence for sporadic outbreaks of respiratory disease caused by notifiable viral pathogens (AIV, IBV, NDV, and ILTV), as well as outbreaks of diseases caused by immunosuppressive viral pathogens (IBDV and FADV Gp1). This review highlights the need to strengthen current levels of surveillance and reporting for poultry diseases in domestic and wild bird populations across the Caribbean, as well as the need to strengthen the diagnostic capacity and capability of Caribbean national veterinary diagnostic laboratories.

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Molecular Characterization of Brazilian Infectious Bursal Disease Virus Isolated from 1997 to 2005

Cited by 13 publications

References 18 publications

Classification of infectious bursal disease virus into genogroups

Classification of infectious bursal disease virus into genogroups

Selected aspects of infectious bursal disease – the current state of knowledge

A Review of Eight High-Priority, Economically Important Viral Pathogens of Poultry within the Caribbean Region

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