Molecular characterization of a reassortant H11N9 subtype avian influenza virus isolated from a domestic duck in Eastern China

Wu, Haibo; Peng, Xiuming; Peng, Xiaorong; Wu, Nanping

doi:10.1007/s00705-015-2528-6

Cited by 11 publications

(11 citation statements)

References 34 publications

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“…These events most likely occurred in LPMs and could be transmitted from ducks to chickens ( 48 ). The internal genes of H3N8 AIVs were derived from a variety of AIVs from wild birds or domestic ducks ( 24 , 49 - 50 ), including HPAI H5 viruses ( 28 , 43 , 51 - 52 ).…”

Section: Genetic Evolution Of H3 Aivs In Chinamentioning

confidence: 99%

Epidemiological and Genetic Characteristics of the H3 Subtype Avian Influenza Viruses in China

Yang¹,

Yang²,

Zhu³

et al. 2021

China CDC Weekly

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Section: Genetic Evolution Of H3 Aivs In Chinamentioning

confidence: 99%

Epidemiological and Genetic Characteristics of the H3 Subtype Avian Influenza Viruses in China

Yang¹,

Yang²,

Zhu³

et al. 2021

China CDC Weekly

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“…In particular, H5 and H7 strains are considered the most relevant for the poultry industry due to their potential for high pathogenicity to chickens, whereas H1, H3, H5 and H7 strains have been documented to cause disease in humans, and recent H5N1 and H7N9 epidemics have resulted in significant human morbidity and mortality [ 4 ]. On the other hand, even though H11 strains have been shown to infect humans who have frequent contact with infected birds [ 5 , 6 ], this subtype seems primarily associated with birds and has not been associated with signs of illness or mortality in any hosts [ 7 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil

et al. 2015

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Migratory aquatic birds play an important role in the maintenance and spread of avian influenza viruses (AIV). Many species of aquatic migratory birds tend to use similar migration routes, also known as flyways, which serve as important circuits for the dissemination of AIV. In recent years there has been extensive surveillance of the virus in aquatic birds in the Northern Hemisphere; however in contrast only a few studies have been attempted to detect AIV in wild birds in South America. There are major flyways connecting South America to Central and North America, whereas avian migration routes between South America and the remaining continents are uncommon. As a result, it has been hypothesized that South American AIV strains would be most closely related to the strains from North America than to those from other regions in the world. We characterized the full genome of three AIV subtype H11N9 isolates obtained from ruddy turnstones (Arenaria interpres) on the Amazon coast of Brazil. For all gene segments, all three strains consistently clustered together within evolutionary lineages of AIV that had been previously described from aquatic birds in North America. In particular, the H11N9 isolates were remarkably closely related to AIV strains from shorebirds sampled at the Delaware Bay region, on the Northeastern coast of the USA, more than 5000 km away from where the isolates were retrieved. Additionally, there was also evidence of genetic similarity to AIV strains from ducks and teals from interior USA and Canada. These findings corroborate that migratory flyways of aquatic birds play an important role in determining the genetic structure of AIV in the Western hemisphere, with a strong epidemiological connectivity between North and South America.

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“…H11N9 has been found in wild birds in Brazil, Europe, and Japan [14,17,19,21,22,69,70]. Japan is an overwintering site of endangered cranes (hooded cranes and white-naped cranes) and many other migratory birds (including wild ducks), which are considered as carriers of AIVs [70].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have described that H11N9 isolated in China can replicate not only in avian but also in mammalian cells [20], and even in mice lungs without prior adaption [21,22]. Furthermore, the H7N9 strain, which is one of the few avian influenza viruses (AIVs) that have crossed the species barrier and caused significant human morbidity and mortality, was reported to possess NA originating from the H11N9 or H2N9 strains [23,24].…”

Section: Introductionmentioning

confidence: 99%

Genetic Characterization of Avian Influenza A (H11N9) Virus Isolated from Mandarin Ducks in South Korea in 2018

Tuong

Nguyen

Sung

et al. 2020

Viruses

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In July 2018, a novel avian influenza virus (A/Mandarin duck/South Korea/KNU18-12/2018(H11N9)) was isolated from Mandarin ducks in South Korea. Phylogenetic and molecular analyses were conducted to characterize the genetic origins of the H11N9 strain. Phylogenetic analysis indicated that eight gene segments of strain H11N9 belonged to the Eurasian lineages. Analysis of nucleotide sequence similarity of both the hemagglutinin (HA) and neuraminidase (NA) genes revealed the highest homology with A/duck/Kagoshima/KU57/2014 (H11N9), showing 97.70% and 98.00% nucleotide identities, respectively. Additionally, internal genes showed homology higher than 98% compared to those of other isolates derived from duck and wild birds. Both the polymerase acidic (PA) and polymerase basic 1 (PB1) genes were close to the H5N3 strain isolated in China; whereas, other internal genes were closely related to that of avian influenza virus in Japan. A single basic amino acid at the HA cleavage site (PAIASR↓GLF), the lack of a five-amino acid deletion (residue 69–73) in the stalk region of the NA gene, and E627 in the polymerase basic 2 (PB2) gene indicated that the A/Mandarin duck/South Korea/KNU18-12/2018(H11N9) isolate was a typical low-pathogenicity avian influenza. In vitro viral replication of H11N9 showed a lower titer than H1N1 and higher than H9N2. In mice, H11N9 showed lower adaptation than H1N1. The novel A/Mandarin duck/South Korea/KNU18-12/2018(H11N9) isolate may have resulted from an unknown reassortment through the import of multiple wild birds in Japan and Korea in approximately 2016–2017, evolving to produce a different H11N9 compared to the previous H11N9 in Korea (2016). Further reassortment events of this virus occurred in PB1 and PA in China-derived strains. These results indicate that Japanese- and Chinese-derived avian influenza contributes to the genetic diversity of A/Mandarin duck/South Korea/KNU18-12/2018(H11N9) in Korea.

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Molecular characterization of a reassortant H11N9 subtype avian influenza virus isolated from a domestic duck in Eastern China

Cited by 11 publications

References 34 publications

Epidemiological and Genetic Characteristics of the H3 Subtype Avian Influenza Viruses in China

Epidemiological and Genetic Characteristics of the H3 Subtype Avian Influenza Viruses in China

Molecular Characterization of Subtype H11N9 Avian Influenza Virus Isolated from Shorebirds in Brazil

Genetic Characterization of Avian Influenza A (H11N9) Virus Isolated from Mandarin Ducks in South Korea in 2018

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