Molecular Characterization of a MSRV-like Sequence Identified by RDA from Monozygotic Twin Pairs Discordant for Schizophrenia

Deb-Rinker, Paromita; Ta, Klempan; Rl, O'Reilly; Torrey, Ε. Fuller; Sm, Singh

doi:10.1006/geno.1999.5946

Cited by 61 publications

(29 citation statements)

References 34 publications

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“…46 Retroviruses Retrovirus infection, that can be integrated into genome, could also explain the discordance between twins. 47,48 Relevance of epigenetics in mental disorders The field of epigenetics is too broad to be covered by this short review on discordant twins. Epigenetic regulation of gene expression is used in a wide variety of biological functions, such as tissue-specific gene expression, differentiation of cells, epigenetic memory, suppression of retroelements, and genomic imprinting.…”

Section: Mitochondrial Dna (Mtdna) Heteroplasmymentioning

confidence: 99%

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Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders

et al. 2005

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Classical twin research focused on differentiating genetic factors from environmental factors by comparing the concordance rate between monozygotic (MZ) and dizygotic twins. On the other hand, recent twin research tries to identify genetic or epigenetic differences between MZ twins discordant for mental disorders. There are a number of reports of MZ twins discordant for genetic disorders caused by genetic or epigenetic differences of known pathogenic genes. In the case of mental disorder research, for which the causative gene has not been established yet, we are trying to identify the 'pathogenic gene' by comprehensive analysis of genetic or epigenetic difference between discordant MZ twins. To date, no compelling evidence suggesting such difference between MZ twins has been reported. However, if the genetic or epigenetic difference responsible for the discordant phenotype is found, it will have impact on the biology of mental disorder, in which few conclusive molecular genetic evidences have been obtained.

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Section: Mitochondrial Dna (Mtdna) Heteroplasmymentioning

confidence: 99%

“…DNA methylation: Deb-Rinker et al 47,48 analyzed the lymphocytes obtained from MZ twins discordant for schizophrenia using RDA and found a new retrovirus, which was expressed only in the affected twin. They named this as schizophrenia-related retrovirus-1 (SZRV-1) and SZRV-2.…”

Section: Search For Epigenetic Discordance Between Mz Twinsmentioning

confidence: 99%

Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders

et al. 2005

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“…Quelques années plus tard, Deb-Rinker et al mettaient, pour la première fois, en évidence la présence de la séquence du HERV-W chez trois paires de jumeaux monozygotes discordants pour la SCZ [20]. Depuis, plusieurs études se sont attachées à rechercher des preuves de la réac-tivation des HERV dans les échantillons de cerveaux de patients (Tableau I).…”

Section: Les Herv Dans La Schizophrénie Et Le Trouble Bipolaireunclassified

Les rétrovirus endogènes humains, une implication dans la schizophrénie et le trouble bipolaire

2017

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“…Additional evidence for epigenetic differences between MZ twins discordant for schizophrenia comes from two studies by Deb-Rinker et al [1999. The group identified and sequenced two retroviruses in the affected twins from MZ twin pairs discordant for schizophrenia using representational difference analysis (RDA).…”

Section: Epigenetic Regulation Of Gene Expressionmentioning

confidence: 99%

Not really identical: Epigenetic differences in monozygotic twins and implications for twin studies in psychiatry

Haque

Gottesman

Wong

2009

American J of Med Genetics Pt C

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Classical twin studies in the field of psychiatry generally fall into one of two categories: (1) those designed to identify environmental risk factors causing discordance in monozygotic (MZ) twins and (2) those geared towards identifying genetic risk factors. However, neither environment nor differences in DNA sequence can fully account for phenotypic discordance among MZ twins. The field of epigenetics -DNA modifications that can affect gene expression -offers new models to understand discordance in MZ twins. In the past, MZ twins were regarded as genetically-identical controls for differing environmental conditions. In contrast, the evolving current concept is that epigenetic differences between MZ twins may modulate differences in diverse phenotype, from disease to personality. In this article, we review some twin studies, and discuss the dynamic interactions between stochastic, environmental, and epigenetic variables that influence neurobiological phenotypes. ß

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Molecular Characterization of a MSRV-like Sequence Identified by RDA from Monozygotic Twin Pairs Discordant for Schizophrenia

Cited by 61 publications

References 34 publications

Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders

Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders

Les rétrovirus endogènes humains, une implication dans la schizophrénie et le trouble bipolaire

Not really identical: Epigenetic differences in monozygotic twins and implications for twin studies in psychiatry

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