Molecular Characterization of a Functional Membrane-Associated Progesterone Receptor Component 2 (PGRMC-2) in Maturing Oocytes of the Human Parasite Nematode <i>Trichinella spiralis</i>: Implications to the Host-Parasite Relationship
Abstract:We explored the hypothesis that progesterone direct effect on Trichinella spiralis might be mediated indeed by a new steroid-binding parasite protein. Our first results showed that Progesterone decreases the parasite molting rate. We amplify, isolated, cloned and sequenced the PGRMC2 sequence using specific primers from known species. Furthermore, we expressed the protein and developed an antibody to performance immunofluorescent confocal microscopy, where detected that parasite cells showed expression of a P4… Show more
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