Molecular characterization, expression analysis and cellular location of IL-4/13 receptors in large yellow croaker (Larimichthys crocea)

Yuan, Xiaoqin; Rong, Yi; Chen, You; Ren, Chao; Meng, Yufan; Mu, Yinnan; Chen, Xinhua

doi:10.1016/j.fsi.2021.11.007

Cited by 10 publications

(1 citation statement)

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“…To date, IL-21 has been identi ed in a variety of sh species (Distler et al 2005;Wang et al 2006;Bird et al 2005;Zou et al 2016). Many studies have shown that IL-21 induces the expression of interferon and a class of cytokines in teleost sh (Vosshenrich et al 2001;Mu et al 2021;Yuan et al 2022;Chao et al 2020). For example, the IL-21 can effectively induce the expression of IL-10 and TNFα in grass carp or rainbow trout.…”

Section: Introductionmentioning

confidence: 99%

Identification and expression analysis of an IL-21 receptor in large yellow croaker (Larimichthys crocea)

Teng

et al. 2023

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Interleukin-21 (IL-21) is a potent immunomodulatory cytokine with pleiotropic effects on both innate and adaptive immune responses. It signaling involves a heterodimeric receptor complex consisting of the IL-21 receptor (IL-21R) and the common γ chain (γC). In this study, we identified a homologue gene of IL-21R (LcIL-21R) in the large yellow croaker (Larimichthys crocea, Lc). The open reading frame (ORF) of LcIL-21R gene is 1629 bp long and encodes a precursor protein of 542 amino acids (aa), with a 23-aa signal peptide and a 519-aa mature peptide containing four putative N-glycosylation sites. LcIL-21R has two fibronectin type III (FNIII)-like domains (D1 and D2), a transmembrane domain, and a cytoplasmic region. A conserved WSXWS motif was also found in the D2 domain. The predicted structure of the extracellular region of LcIL-21R (LcIL-21R-Ex) is highly similar to that of human IL-21R. LcIL-21R was constitutively expressed in all tissues examined, and LcIL-21R mRNA levels were increased in head kidney and spleen upon inactivated trivalent bacterial vaccine or poly(I:C) stimulation. Overall, our results suggest that LcIL-21R shares structural and functional properties with IL-21Rs found in other vertebrates, indicating its potential involvement in the IL-21-mediated immune response to pathogenic infections. These findings contribute to our understanding of the evolutionary conservation of IL-21 signaling and its role in the immune system.

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Section: Introductionmentioning

confidence: 99%

Identification and expression analysis of an IL-21 receptor in large yellow croaker (Larimichthys crocea)

Teng

et al. 2023

Preprint

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The identification and expression of an interleukin-21 receptor in large yellow croaker (Larimichthys crocea)

Wu,

Fu,

Teng

et al. 2023

Mol Biol Rep

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Peptide chain release factor methyltransferase gene hemK regulates multiple bacterial phenotypes and is essential for the pathogenicity of Pseudomonas plecoglossicida

Molecular characterization, expression analysis and cellular location of IL-4/13 receptors in large yellow croaker (Larimichthys crocea)

Cited by 10 publications

References 50 publications

Identification and expression analysis of an IL-21 receptor in large yellow croaker (Larimichthys crocea)

Identification and expression analysis of an IL-21 receptor in large yellow croaker (Larimichthys crocea)

The identification and expression of an interleukin-21 receptor in large yellow croaker (Larimichthys crocea)

Peptide chain release factor methyltransferase gene hemK regulates multiple bacterial phenotypes and is essential for the pathogenicity of Pseudomonas plecoglossicida

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