Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor

Rullah, Kamal; Aluwi, Mohd Fadhlizil Fasihi Mohd; Yamin, Bohari Mohd.; Baharuddin, M. S.; Ismail, Nor Hadiani; Teruna, Hilwan Yuda; Bukhari, Syed Nasir Abbas; Jantan, Ibrahim; Jalil, Juriyati; Husain, Khairana; Lam, Kok Wai

doi:10.1016/j.molstruc.2014.10.004

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Cited by 14 publications

References 36 publications

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Palladium‐Catalysed Cross‐Coupling Reactions for the Synthesis of Chalcones

et al. 2019

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In this Minireview, we discuss some of the important palladium-catalysed cross-coupling reactions utilised in the synthesis of the enone system of chalcones. Examples given here not only exemplify the efficiency and practicality of new CÀ C bond formation of the enone system via palladium-catalysed reactions but also reflect some of the revolutionary methods used for the preparation of a more complex and valuable chalcone scaffold which is known to be a privileged structure in the field of medicinal chemistry.

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Palladium‐Catalysed Cross‐Coupling Reactions for the Synthesis of Chalcones

et al. 2019

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Oxygen-Promoted Suzuki-Miyaura Reaction for Efficient Construction of Biaryls

2015

The Chemical Record

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As one of the most powerful and versatile methods for the construction of carbon-carbon bonds, the Suzuki-Miyaura cross-coupling reaction has attracted great attention over the past three decades. In recent years, a huge amount of interest has been focused on the development of ligand-free Suzuki-Miyaura reaction systems, which have the advantages of low cost, mild reaction conditions, and easy operation. So far, a number of ligand-free Suzuki-Miyaura reaction systems have been developed by using simple palladium salts, nanopalladium, or supported palladium catalysts. In this account, we will review our recent research on the oxygen-promoted ligand-free Suzuki-Miyaura reaction. Interestingly, the oxygen-promoting effect has been observed in different reaction media, including polyethylene glycol, organic/water mixed solvents and pure water. The oxygen-promoted reaction systems demonstrate high efficiency for the construction of biaryls.

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