Molecular Characterization and Function of Bone Morphogenetic Protein 7 (BMP7) in the Pacific Abalone, Haliotis discus hannai

Huang, Jianfang; Zhou, Mingcan; Wang, You; Luo, Xuan; Ke, Caihuan

doi:10.3390/genes14061128

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Interestingly, our analysis revealed transcripts and genes associated with IKKβ but not IKKα. The absence of IKKα in the E. scolopes genome and reference transcriptome was surprising as it has been observed in other cephalopods, such as Octopus vulgaris and Haliotis discus hannai 65 , 66 . These results suggest that the IKK complex in the E. scolopes may exhibit an alternate configuration and may not follow the canonical pathway NFκB activation 67 .…”

Section: Resultsmentioning

confidence: 91%

Impact of modeled microgravity stress on innate immunity in a beneficial animal-microbe symbiosis

Duscher,

Vroom,

Foster

2024

Sci Rep

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The innate immune response is the first line of defense for all animals to not only detect invading microbes and toxins but also sense and interface with the environment. One such environment that can significantly affect innate immunity is spaceflight. In this study, we explored the impact of microgravity stress on key elements of the NFκB innate immune pathway. The symbiosis between the bobtail squid Euprymna scolopes and its beneficial symbiont Vibrio fischeri was used as a model system under a simulated microgravity environment. The expression of genes associated with the NFκB pathway was monitored over time as the symbiosis progressed. Results revealed that although the onset of the symbiosis was the major driver in the differential expression of NFκB signaling, the stress of simulated low-shear microgravity also caused a dysregulation of expression. Several genes were expressed at earlier time points suggesting that elements of the E. scolopes NFκB pathway are stress-inducible, whereas expression of other pathway components was delayed. The results provide new insights into the role of NFκB signaling in the squid-vibrio symbiosis, and how the stress of microgravity negatively impacts the host immune response. Together, these results provide a foundation to develop mitigation strategies to maintain host-microbe homeostasis during spaceflight.

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Section: Resultsmentioning

confidence: 91%

Impact of modeled microgravity stress on innate immunity in a beneficial animal-microbe symbiosis

Duscher,

Vroom,

Foster

2024

Sci Rep

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Construction of a high‐density linkage map and QTL detection for growth traits in South African abalone (Haliotis midae)

Tshilate,

Ishengoma,

Rhode

2024

Animal Genetics

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Haliotis midae is one of the most important molluscs in South African commercial aquaculture. In this study, a high‐resolution integrated linkage map was constructed, and QTL identified using 2b‐RADseq for genotyping SNPs in three families. The final integrated linkage map was composed by merging the individual family maps, resulting in 3290 informative SNPs mapping to 18 linkage groups, conforming to the known haploid chromosome number for H. midae. The total map spanned 1798.25 cM with an average marker interval of 0.55 cM, representing a genome coverage of 98.76%. QTL analysis, across all three families, resulted in a total of five QTL identified for growth‐related traits, shell width, shell length, and total body weight. For shell width and total body weight, one QTL was identified for each trait respectively, whilst three QTL were identified for shell length. The identified QTL respectively explained between 7.20% and 11.40% of the observed phenotypic variance. All three traits were significantly correlated (r = 0.862–0.970; p < 0.01) and shared overlapping QTL. The QTL for growth traits were mapped back to the H. midae draft genome and BLAST searches revealed the identity of candidate genes, such as egf‐1, megf10, megf6, tnx, sevp1, kcp, notch1, and scube2 with possible functional roles in H. midae growth. The constructed high‐density linkage map and mapped QTL have given valuable insights regarding the genetic architecture of growth‐related traits and will be important genetic resources for marker‐assisted selection. It remains, however, important to validate causal variants through linkage disequilibrium fine mapping in future.

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Molecular Characterization and Function of Bone Morphogenetic Protein 7 (BMP7) in the Pacific Abalone, Haliotis discus hannai

Cited by 2 publications

References 54 publications

Impact of modeled microgravity stress on innate immunity in a beneficial animal-microbe symbiosis

Impact of modeled microgravity stress on innate immunity in a beneficial animal-microbe symbiosis

Construction of a high‐density linkage map and QTL detection for growth traits in South African abalone (Haliotis midae)

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