Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia

Saleem, Mohd; Khaja, Azharuddin Sajid Syed; Hossain, Ashfaque; Alenazi, Fahaad; Said, Kamaleldin B.; Moursi, Soha Abdallah; Rakha, Ehab

doi:10.3390/healthcare10112210

Cited by 6 publications

(11 citation statements)

References 45 publications

(52 reference statements)

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“…These MDR pathogens are increasing the burden on the healthcare systems due to nosocomial infections in the ICU settings. [34][35][36] Our study showed that P. aeruginosa and A. baumannii produced three types of beta-lactamases, including MBL, ESBL, and AmpC. In contrast, K. pneumoniae isolates did not produce MBL.…”

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confidence: 67%

Pathogen Burden Among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile

Saleem¹,

Khaja²,

Hossain³

et al. 2023

IDR

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Ventilator-associated pneumonia (VAP) is associated with a higher mortality risk for critical patients in the intensive care unit (ICU). Several strategies, including using β-lactam antibiotics, have been employed to prevent VAP in the ICU. However, the lack of a gold-standard method for VAP diagnosis and a rise in antibiotic-resistant microorganisms have posed challenges in managing VAP. The present study is designed to identify, characterize, and perform antimicrobial susceptibility of the microorganisms from different clinical types of infections in ICU patients with emphasis on VAP patients to understand the frequency of the latter, among others. Patients and Methods: A 1-year prospective study was carried out on patients in the ICU unit at a tertiary care hospital, Hail, Saudi Arabia. Results: A total of 591 clinically suspected hospital-acquired infections (HAI) were investigated, and a total of 163 bacterial isolates were obtained from different clinical specimens with a high proportion of bacteria found associated with VAP (70, 43%), followed by CAUTI (39, 24%), CLABSI (25, 15%), and SSI (14, 8.6%). Klebsiella pneumoniae was the most common isolate 39 (24%), followed by Acinetobacter baumannii 35 (21.5%), Pseudomonas aeruginosa 25 (15.3%), and Proteus spp 23 (14%). Among the highly prevalent bacterial isolates, extended-spectrum beta-lactamase was predominant 42 (42.4%). Conclusion: Proper use of antibiotics, continuous monitoring of drug sensitivity patterns, and taking all precautionary measures to prevent beta-lactamase-producing organisms in clinical settings are crucial and significant factors in fending off life-threatening infections for a better outcome.

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confidence: 67%

Pathogen Burden Among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile

Saleem¹,

Khaja²,

Hossain³

et al. 2023

IDR

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“…The prevalence of ventilator-associated pneumonia (VAP) in Saudi Arabia is a significant concern, as it is one of the most common healthcare-associated infections in the country. The variation in the prevalence of the VAP found among prospective and retrospective studies is likely due to the selection criteria of the healthcare setting and patient population [34,39,43]. Most of the studies included patients with VAP only.…”

Section: Discussionmentioning

confidence: 99%

“…The rate of resistance to cephalosporins in Saudi Arabia ranges from 9-98% [24,47]. However, the majority of the strains are susceptible to colistin [34,45,51]. Current data on antibiotic resistance and susceptibility patterns is insufficient, and there are calls for more comprehensive studies to be conducted, including testing for atypical pathogens.…”

Section: Discussionmentioning

confidence: 99%

“…Table 2 summarizes the susceptibility and resistance pattern of bacterial isolates responsible for pneumonia. The disc diffusion method was used in the majority of the studies to test the susceptibility/resistance patterns of antibiotics [23,24,29,30,32,34,43]. The susceptibility and resistance were determined against different classes of antibiotics: carbapenems (meropenem and imipenem), penicillins (penicillin, amoxicillin, piperacillin, and ampicillin), quinolones (ciprofloxacin and levofloxacin), cephalosporins (cefuroxime, ceftriaxone, cefotaxime, cefixime, cefepime, and ceftazidime), aminoglycosides (amikacin and gentamicin), folate pathway inhibitors (sulfamethoxazole/trimethoprim), polymixin (colistin), and macrolides (azithromycin).…”

Section: Antimicrobial Susceptibility/resistance Patternmentioning

confidence: 99%

“…Acinetobacter spp. showed a high resistance rate to quinolones (ciprofloxacin and moxifloxacin), cephalosporins (ceftazidime, and cefepime), and carbapenems (meropenem and imipenem); these species are highly susceptible to colistin [32,34]. However, two of the included studies reported that meropenem exhibit high susceptibility rates against Acinetobacter specie [24,47].…”

Section: Antimicrobial Susceptibility/resistance Patternmentioning

confidence: 99%

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Prevalence and Etiology of Community- and Hospital-Acquired Pneumonia in Saudi Arabia and Their Antimicrobial Susceptibility Patterns: A Systematic Review

et al. 2023

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(1) Background and Objectives: Pneumonia is a major cause of morbidity and mortality worldwide, including in Saudi Arabia, and the prevalence and etiology of the disease varies depending on the setting. The development of effective strategies can help reduce the adverse impact of this disease. Therefore, this systematic review was conducted to explore the prevalence and etiology of community-acquired and hospital-acquired pneumonia in Saudi Arabia, as well as their antimicrobial susceptibility. (2) Materials and Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 recommendations were followed for this systematic review. Several databases were used to perform a thorough literature search, and papers were then assessed for eligibility by two independent reviewers. The Newcastle-Ottawa Scale (NOS) was used to extract the data from the relevant research and evaluate its quality. (3) Results: This systematic review included 28 studies that highlighted the fact that gram-negative bacteria, particularly Acinetobacter spp. and Pseudomonas aeruginosa, were the common cause of hospital-acquired pneumonia, while Staphylococcus aureus and Streptococcus spp. were responsible for community-acquired pneumonia in children. The study also found that bacterial isolates responsible for pneumonia showed high resistance rates against several antibiotics, including cephalosporins and carbapenems. (4) Conclusions: In conclusion, the study found that different bacteria are responsible for community- and hospital-acquired pneumonia in Saudi Arabia. Antibiotic resistance rates were high for several commonly used antibiotics, highlighting the need for rational antibiotic use to prevent further resistance. Moreover, there is a need to conduct more regular multicenter studies to assess etiology, resistance, and susceptibility patterns of pneumonia-causing pathogens in Saudi Arabia.

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WGS-based screening of the co-chaperone protein DjlA-induced curved DNA binding protein A (CbpA) from a new multidrug-resistant zoonotic mastitis-causing Klebsiella pneumoniae strain: a novel molecular target of selective flavonoids

Rahman,

Al Azad,

Uddin

et al. 2023

Mol Divers

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Molecular Characterization and Antibiogram of Acinetobacter baumannii Clinical Isolates Recovered from the Patients with Ventilator-Associated Pneumonia

Cited by 6 publications

References 45 publications

Pathogen Burden Among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile

Pathogen Burden Among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile

Prevalence and Etiology of Community- and Hospital-Acquired Pneumonia in Saudi Arabia and Their Antimicrobial Susceptibility Patterns: A Systematic Review

WGS-based screening of the co-chaperone protein DjlA-induced curved DNA binding protein A (CbpA) from a new multidrug-resistant zoonotic mastitis-causing Klebsiella pneumoniae strain: a novel molecular target of selective flavonoids

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