Molecular characteristics of the VP1 region of enterovirus 71 strains in China

Sun, Haiyan; Gao, Min; Cui, Dawei

doi:10.1186/s13099-020-00377-2

Cited by 9 publications

(8 citation statements)

References 54 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the major circulating strains of EV-A71 were genotype C4a in China [ 29 , 35 ]. The widespread use of the EV-A71 vaccines might affect the landscape of other genotypes in circulation, but the sub-genotype switch of EV-A71 has not been observed or reported in China [ 36 , 37 ]. Further studies on EV-A71 genome characteristics based on the national surveillance are still useful and essential for monitoring the emergence of new variants and preventing HFMD outbreaks.…”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017-2022: a descriptive study

Duan

Zhang

Wang

et al. 2022

Emerging Microbes & Infections

View full text Add to dashboard Cite

Three inactivated enterovirus A71 (EV-A71) vaccines have been widely vaccinated among children in the targeted age group in mainland China since mid-2016. However, comprehensive virological surveillance of hand, foot and mouth disease (HFMD) over multiple years after the use of EV-A71 vaccines has rarely been conducted. Using long-term data extracted from the Public Health and Clinical Center of Chengdu, we described the clinical, aetiological, and epidemiological characteristics of HFMD inpatients after the use of EV-A71 vaccines from 2017 through 2022. A total of 5115 patients were selected for analysis with a male-to-female ratio of 1.63:1 and were mostly under 5 years of age (97.6%). Among these cases, 4.3% presented with severe symptoms, and 4.1% of severe cases experienced significant complications. EV-A71 was no longer the major serotype for laboratory-confirmed HFMD, responsible for 15.6% of severe cases and 1.2% of mild cases. A significant downwards trend of EV-A71 infections was observed after the use of EV-A71 vaccines (P for trend < 0.001). Coxsackievirus A6 was the predominant pathogen, accounting for 63.5% of mild cases and 36.2% of severe cases. Coxsackievirus A10 (CV-A10) and A16 were sporadically detected, and an upwards trend was observed in the proportion of CV-A10 infections. This study provides baseline molecular epidemiology for the evaluation of EV-A71 vaccination impact and potential serotype replacement based on HFMD inpatients. Additional nationwide and population-based epidemiologic and serologic studies are essential to elucidate HFMD dynamics after the use of EV-A71 vaccines, and to inform public health authorities to introduce optimized intervention strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017-2022: a descriptive study

Duan

Zhang

Wang

et al. 2022

Emerging Microbes & Infections

View full text Add to dashboard Cite

show abstract

“…The sequences of the strains collected in the provinces of South Vietnam formed a monophyletic cluster with the nucleotide sequences of EV-A71 viruses circulating in some provinces of China during 2016-2018 and in Germany during 2018-2019 [20,35]. The highest homology (99.2-99.9%) of the nucleotide sequences of majority of Vietnamese strains belonging to this genetic group was revealed with the strains identified in patients with HFMD and AFP from the Chinese province of Yunnan in 2017-2018.…”

Section: Figure 1 Phylogenic Relationship Between Ev-a71 Strains Of Genotype C4 Identified In Russia and Vietnammentioning

confidence: 99%

Epidemiological and etiological aspects of enterovirus infection in Russia and Vietnam

Romanenkova

Голицына

Nguyen

et al. 2021

Russian Journal of Infection and Immunity

View full text Add to dashboard Cite

The epidemic situation and etiological factors of enterovirus infection in Russia and Vietnam were analysed and compared. The identified strains of enteroviruses of 47 types, which circulated in Russia in 2018–2019, belonged to different species: Enterovirus species A (CV-A2, CV-A4, CV-A6, CV-A8, CV-A10, CV-A16, EV-A71), as well as Enterovirus species B and Enterovirus species C. The strains isolated from 87 children from southern Vietnam hospitalised in 2018–2019 into infectious hospitals while having enterovirus infection with exanthema were also studied. All identified strains were represented by Enterovirus species A: EV-A71 — 59 strains, CV-A10 — 20 strains, CV-A16 — 5 strains, CV-A6 — two strains and CV-A2 — one strain. Out of 59 viruses EV-A71, 53 strains belonged to genotype C4 and 6 strains belonged to genotype B5. The sequences of EV-A71 strains of genotype C4 from South Vietnam formed a monophyletic cluster with the sequences of EV-A71 viruses which circulated during 2016–2018 in different provinces of China, and they were very close to EV-A71 strains of the same genotype from the Yunnan Province. These strains were genetically different from Russian viruses and Vietnamese viruses identified in the years 2003–2005 and 2011– 2012. Most of the cases of enterovirus infection from southern Vietnam (78%) caused by EV-A71 virus of genotype C4 were reported in three provinces located in southern Vietnam in the Mekong Delta. The epidemic process and the etiology of enterovirus infection in Russia and Vietnam have common features. At the same time, the epidemic situation in these countries is not the same. The incidence of enterovirus infection is influenced by geographic, climatic, economic and demographic factors that differ in two countries. In the majority of territories of Russia, the climate is temperate or cold, seasonal rises in the incidence rates of enterovirus infection usually occur in the summer, when people go on vacation, spend a lot of time outdoors and swim in open reservoirs. In Vietnam, a constant high-level temperature, a high population density and a large proportion of children determine the higher incidence of enterovirus infection, especially in the southern provinces of Vietnam, compared to Russia. The fact that more than 20% of the Vietnamese population lives in the Mekong Delta, which is the largest river in Indochina, has a significant impact on the epidemic process of enterovirus infection in South Vietnam. The Mekong River which flows through China, Laos, Thailand, Cambodia and Vietnam, and carries huge streams of water, including rainstorm waters and sewages, from all of these countries into the southern provinces of Vietnam, which have the highest incidence rates of enterovirus infection in the country. The results of the research underline the importance of active epidemiological and virological surveillance of enterovirus infection, which plays the key role in informing the public health authorities about the changes in the epidemic situation in order to take appropriate measures and develop the prevention strategies. The goal of anti-epidemic and preventive measures is to reduce the incidence of enterovirus infection and the economic burden of this infection for Russia and Vietnam.

show abstract

“…Strain VND18/227 identified in one HFMD patient, who had a complicated clinical form of the disease, was very close to German EVA71 strains (99.2–99.4% of homology) of the C4 genotype. All these viruses represented a separate genetic group and had a high relationship with EVA71 strains detected in the Guangdong province of China in 2017 [ 12 ]. EVA71 viruses of the C4 genotype revealed in HFMD and AFP cases from our study were different from viruses revealed in 2003–2005 and 2011–2012 during HFMD outbreaks in South and North Vietnam [ 9 , 13 , 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…Enteroviruses A-D species genus Enteroviruses family Picornaviridae are associated with human enteroviral infection. Enteroviral infection (EVI) is characterized by a wide diversity of clinical forms, including enteroviral meningitis, meningoencephalitis, hand-foot-and-mouth disease (HFMD), and other clinical manifestations [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Enterovirus 71-Associated Infection in South Vietnam: Vaccination Is a Real Solution

Romanenkova

Nguyen²,

Голицына

et al. 2023

Vaccines

View full text Add to dashboard Cite

Hand-foot-and-mouth disease (HFMD) is the most common enteroviral infection in South-East Asia. When evaluating the role of enterovirus 71 (EVA71) as an etiological agent of infectious disease in South Vietnam, we revealed a high proportion of EVA71 among identified species A enteroviruses found in 3542 samples from HFMD cases; 125 samples from cases of enteroviral meningitis; and 130 samples from acute flaccid paralysis (AFP) cases. These represent 50%, 54.8%, and 51.5%, respectively. According to molecular analysis, 90% of EVA71 were attributed to genotype C4 and 10% were attributed to genotype B5. The predominance of EVA71 circulation among the population proves the need to strengthen surveillance (with monitoring of enterovirus circulation for facilitation of HFMD outbreak prediction) and to increase the effectiveness of preventative measures by the implementation of vaccination against EVA71-associated infections. A phase III trial of a Taiwanese vaccine (EV71vac) in Taiwan and South Vietnam showed its safety, tolerability, and efficacy in children aged 2–71 months. This B4 genotype-based vaccine, which features cross-protection against B5 and C4 genotypes, and other existing EV71 vaccines can serve as a good approach to solving the HFMD problem, which is so important for Vietnam.

show abstract

Molecular characteristics of the VP1 region of enterovirus 71 strains in China

Cited by 9 publications

References 54 publications

Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017-2022: a descriptive study

Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017-2022: a descriptive study

Epidemiological and etiological aspects of enterovirus infection in Russia and Vietnam

Enterovirus 71-Associated Infection in South Vietnam: Vaccination Is a Real Solution

Contact Info

Product

Resources

About