Molecular characteristics associated with ferroptosis in hepatocellular carcinoma progression

Zuo, Fei; Yin, Lei; Jing, Zhuang; Xi, Yang; Pan, Yuefen; Han, Shuwen

doi:10.1007/s13577-020-00431-w

Cited by 22 publications

(22 citation statements)

References 42 publications

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“…HSPB1 is a key regulator of ferroptosis in cancer cells, and HSPB1 is a negative regulator of ferroptosis by reducing iron‐mediated production of lipid reactive oxygen species 31 . Other studies have shown that HSPB1 plays an important role in the progression of liver cancer and ferroptosis, and that HSPB1 may be regulated by transcription factor ATF3 32 . Studies have found that protease degradation is more abundant in atherosclerosis than in normal arteries 33 …”

Section: Discussionmentioning

confidence: 99%

Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from coronary artery disease

Qin

Iroegbu

et al. 2022

J Cellular Molecular Medi

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Coronary artery disease (CAD) is a type of disease in which the lumen is narrowed or blocked due to atherosclerotic lesions in the coronary artery, resulting in myocardial ischaemia, oxygen deprivation and necrosis. CAD is one of the highest mortality diseases in the world, with an estimated 12 million deaths due to coronary atherosclerosis by the end of 2030, including non-ST-segment elevation myocardial infarction and ST segment elevation myocardial infarction. 1 The pathogenesis of CAD is complex, and there are no obvious

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Section: Discussionmentioning

confidence: 99%

Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from coronary artery disease

Qin

Iroegbu

et al. 2022

J Cellular Molecular Medi

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“…In this team, nurses carry out role coordination, establish the team supporting operation process and mechanism, formulate relevant standard system, train and assess team members, so as to ensure that all departments and roles can actively cooperate and assist, carry out standardized process implementation, and achieve better treatment effect. The emergency nursing mode constructed in this study is applied to the emergency treatment of patients with traumatic shock, which shortens the response time of hospital rescue, improves the success rate of rescue, reduces the incidence of complications, and improves the satisfaction of patients' family members [ 32 ]. On the one hand, the development of this study can provide a new idea for the first aid of patients with traumatic shock; on the other hand, it can also provide reference for the treatment of other diseases.…”

Section: Discussionmentioning

confidence: 99%

The Value of Emergency Nursing Mode in the Treatment of Patients with Traumatic Shock

Jin-mei

Zhou

Wang

et al. 2022

Journal of Healthcare Engineering

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Objective. To study the value of emergency nursing mode in patients with traumatic shock. Methods. 76 patients with traumatic shock in our hospital from March 2019 to February 2021 were selected and divided into study group and control group according to different rescue modes, 38 cases in each group. The study group adopted emergency nursing mode for rescue, while the control group adopted routine nursing mode for rescue. The rescue intervention, emergency stay and preoperative preparation time, rescue success rate, emergency rescue effect, complications, and satisfaction rate of patients and their families for rescue were compared between the two groups. Results. The rescue intervention, emergency stay and preoperative preparation time of the study group were significantly shorter than those of the control group, and the difference was statistically significant ( P < 0.05 ). The rescue success rate of the study group was 97.37%, which was significantly higher than 84.21% of the control group, and the difference was statistically significant ( P < 0.05 ). The improvement rate of the study group was significantly higher than that of the control group, the disability rate was significantly lower than that of the control group, the overall emergency rescue effect was better than that of the control group, and the difference was statistically significant ( P < 0.05 ). The incidence of complications in the study group was 2.63%, which was significantly lower than 23.68% in the control group ( P < 0.05 ). The satisfaction rate of patients and their families in the study group was 97.37%, which was significantly higher than 84.21% in the control group ( P < 0.05 ). Conclusion. Emergency nursing mode in patients with traumatic shock owns higher rescue value, can buy time for the operation, improve the success rate and effect of rescue, make safety and satisfaction higher. Overall, for patients with traumatic shock, emergency nursing mode is better than conventional rescue nursing.

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“…Besides the MAPK signaling, our results highlighted the involvement of ERK signaling in ferroptosis targeted by GSH. ERK signaling is associated with ferroptosis in many cancers, including multiple myeloma ( Chen J. et al, 2021 ), endometrial carcinoma ( Qin et al, 2021 ), hepatocellular carcinoma ( Fei et al, 2021 ), and pancreatic cancer ( Ye et al, 2020 ). Specifically, the ERK signaling pathway has been linked with ferroptosis and associated with the prognosis of OC ( Chen R. et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology Identifies Therapeutic Targets and the Mechanisms of Glutathione Action in Ferroptosis Occurring in Oral Cancer

Huang

Zhan

2022

Front. Pharmacol.

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Oral cancer (OC) is one of the most pernicious cancers with increasing incidence and mortality worldwide. Surgery is the primary approach for the treatment of early-stage OC, which reduces the quality of life of the patients. Therefore, there is an urgent need to discover novel treatments for OC. Targeting ferroptosis to induce cell death through the modulation of lipid oxidation has been used as a new approach to treat many cancers. Glutathione (GSH) is a coenzyme factor of GSH peroxidase 4, and it carries potential applicability in treating OC. By using network pharmacology and molecular docking followed by systematic bioinformatic analysis, we aimed to study GSH-targeting ferroptosis to treat OC. We identified 14 core molecular targets, namely, EGFR, PTGS2, HIF1A, VEGFA, TFRC, SLC2A1, CAV1, CDKN2A, SLC3A2, IFNG, NOX4, DDIT4, CA9, and DUSP1, involved in ferroptosis that were targeted by GSH for OC treatment. Functional characterization of these molecular targets showed their importance in the control of cell apoptosis, cell proliferation, and immune responses through various kinase activities such as the mitogen-activated protein kinase activity (e.g., ERK1 and ERK2 cascades) and modulation of TOR signaling (e.g., the HIF-1 signaling pathway). Molecular docking further revealed the direct binding of GSH with EGFR, PTGS2, and HIF1A proteins. These findings provide a novel insight into the targets of GSH in ferroptosis as well as possible molecular mechanisms involved, suggesting the possible use of GSH as a combined therapy for treating OC.

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Molecular characteristics associated with ferroptosis in hepatocellular carcinoma progression

Cited by 22 publications

References 42 publications

Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from coronary artery disease

Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from coronary artery disease

The Value of Emergency Nursing Mode in the Treatment of Patients with Traumatic Shock

Network Pharmacology Identifies Therapeutic Targets and the Mechanisms of Glutathione Action in Ferroptosis Occurring in Oral Cancer

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