Molecular Characterisation and Phylogenetic Analysis of Dengue Outbreak in Pasighat, Arunachal Pradesh, Northeast India

Borkakoty, Biswajyoti; Das, Mandakini; Sarma, K. K.; Jakharia, Aniruddha; Das, Palash; Bhattacharya, Chandrakanta; Apum, Basumoti; Biswas, Dipankar

doi:10.4103/ijmm.ijmm_17_30

Cited by 8 publications

(11 citation statements)

References 31 publications

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“…Figure 3 and Table 2 show the temporal distribution of DEN/CHIK in HKH regionper year and month ( Tables S12 and S13 ), respectively. The DEN studies from India, Nepal, and Bhutan specified the monthly distribution of DEN incidence or the months when the DEN outbreak starts to occur and the peak month for the DEN outbreak [ 18 , 19 , 20 , 21 , 23 , 24 , 25 , 27 , 28 , 29 , 32 , 34 , 39 , 40 , 41 , 42 , 43 , 45 , 51 , 56 , 58 , 61 , 62 , 63 , 64 , 71 , 72 ] DEN cases in India start to occur in July [ 18 , 24 , 40 , 51 , 56 ]. However, DEN cases were reported from the month of June to December from Nepal [ 47 , 49 , 50 , 59 , 60 , 62 , 63 , 65 ].…”

Section: Resultsmentioning

confidence: 99%

“…We have calculated the total number of reported and confirmed DEN and CHIK cases from each HKH country, but we have certainly failed to report the true number of DEN and CHIK cases from each HKH country. More than one study was conducted in same period, especially in India [ 17 , 18 , 20 , 21 , 24 , 25 , 26 , 27 , 28 , 36 , 39 , 40 , 42 , 50 , 51 , 54 , 56 , 57 , 60 ] and in Nepal [ 19 , 22 , 23 , 30 , 34 , 37 , 38 , 41 , 43 , 44 , 47 , 49 , 53 , 55 , 58 , 59 , 61 , 64 , 66 , 67 , 69 ]. This might have duplicated the DEN or CHIK cases in our database.…”

Section: Discussionmentioning

confidence: 99%

“…In the HKH region, DENV was first recognized in tea gardens of Northern Assam, India, in 1951 [74]. According to the literature, a large number of states (eight states and two provinces) in the Himalayan and sub-Himalayan region of India have been affected by DEN after 2005 onwards [18,20,21,24,25,27,28,33,36,39,40,42,50,51,54,56,57,60,62,65,71,72,74] The virus circulating in India in the 1950s, causing mild diseases, was replaced or evolved into genotypes with bigger virulence and transmissibility [82]. The movement of the human population from DEN-endemic areas of India to nonendemic areas might have significantly contributed to the outbreak of DEN in new areas and more frequent DEN epidemics after 2005 [57].…”

Section: Discussionmentioning

confidence: 99%

“…DEN was first reported in India in Northern Assam in 1951 [74], in Jammu state in 1974 [72], and in Nagaland in 1994 [71]. No reports were available for the following ten years, but a number of DEN outbreaks from several HKH provinces in India were reported from 2005 to 2017: 2005 in Darjeeling [62]; 2007 and 2008 in Manipur [54,57] and in Assam [60]; 2010 in Uttarakhand and Assam [42,56]; 2011 in Jammu Province [40] and Assam [42]; 2012 in Uttarkhand [36], Jammu Province [40], Assam [42], and Arunachal Pradesh [51]; 2013 from Uttarkhand [18,36,39,50], Jammu province [40], and Assam [42]; 2014 from Uttarakhand [18,39], Assam [20], Arunachal Pradesh [26], Himanchal Pradesh [28], and Jammu province [40]; 2015 in Assam [20], Arunachal Pradesh [21,26], Himanchal Pradesh [28] , and Jammu Province; 2016 from Jorhat, Assam [24], Manipur [25], and Jammu Province [27]; 2017 from Manipur [25]. The average annual temperature of the HKH region is also given.…”

Section: Spatiotemporal Distribution Of Den In Hkh Countriesmentioning

confidence: 99%

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Spatiotemporal Distribution of Dengue and Chikungunya in the Hindu Kush Himalayan Region: A Systematic Review

Phuyal

Kramer

Klingelhöfer

et al. 2020

IJERPH

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The risk of increasing dengue (DEN) and chikungunya (CHIK) epidemics impacts 240 million people, health systems, and the economy in the Hindu Kush Himalayan (HKH) region. The aim of this systematic review is to monitor trends in the distribution and spread of DEN/CHIK over time and geographically for future reliable vector and disease control in the HKH region. We conducted a systematic review of the literature on the spatiotemporal distribution of DEN/CHIK in HKH published up to 23 January 2020, following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. In total, we found 61 articles that focused on the spatial and temporal distribution of 72,715 DEN and 2334 CHIK cases in the HKH region from 1951 to 2020. DEN incidence occurs in seven HKH countries, i.e., India, Nepal, Bhutan, Pakistan, Bangladesh, Afghanistan, and Myanmar, and CHIK occurs in four HKH countries, i.e., India, Nepal, Bhutan, and Myanmar, out of eight HKH countries. DEN is highly seasonal and starts with the onset of the monsoon (July in India and June in Nepal) and with the onset of spring (May in Bhutan) and peaks in the postmonsoon season (September to November). This current trend of increasing numbers of both diseases in many countries of the HKH region requires coordination of response efforts to prevent and control the future expansion of those vector-borne diseases to nonendemic areas, across national borders.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Spatiotemporal Distribution Of Den In Hkh Countriesmentioning

confidence: 99%

See 2 more Smart Citations

Spatiotemporal Distribution of Dengue and Chikungunya in the Hindu Kush Himalayan Region: A Systematic Review

Phuyal

Kramer

Klingelhöfer

et al. 2020

IJERPH

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“…Dengue is a mosquito borne flavivirus belonging to the family flaviviridae which is the most extensively spread mosquito-borne disease (Murhekar et al, 2019). It has five distinct serotypes DENV-1, DENV-2, DENV-3 & DENV-DENV-5 which are distinguished from each other by serological and molecular assays (Rice, Strauss & Strauss, 1986;Borkakoty et al, 2018). These virus are transferred by female Aedes mosquito especially Aedes aegypti and lesser extend Aedes albopictus that feed on human blood both indoors and outdoors during dawn to dusk and can be found in tropical and subtropical region particularly dominant in urban environment and spreading out to rural areas (Mustafa et al, 2015;Brady et al, 2014;Ahmad et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological scenario of dengue in the state of Manipur during the last 3 years

Singh¹,

Singh

2020

PeerJ

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Background The study of disease transmission of dengue fever (DF) is perplexing in the Indian subcontinent as all the four serotypes are circling. Also, there is no efficient epidemiological examination done on dengue cases in Manipur, a north-eastern territory of India. Method We utilized the dengue information extricated from the lab register of Viral Research and Diagnostic Laboratory (VRDL) from 2016 to 2018. All presumed outpatient and inpatients dengue cases from open and private health-care facilities are incorporated into the VRDL database whose informed consent were gotten. Results A sum of 1689 instances of associated patients with dengue infection was tried for dengue ELISA test and 272 (16.10%) samples were seen as seropositive. The month-wise conveyance of dengue cases is very intriguing as the three years of study demonstrates a variation design in perception. In all the three years dengue seropositive cases were seen higher in the male populace. Be that as it may, there is no noteworthy incentive to the inspiration of dengue seropositive towards male than female. Conclusion Our examination exhibits a comparative epidemiological investigation on seroprevelance of dengue in the province of Manipur for three years. This is an endeavour to show epidemiological dengue seroprevelance in the territory of Manipur which in future would be a reference from general wellbeing worries for making up essential move intend to shorten the spread of dengue.

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Molecular Evidence of Wolbachia Species in Wild-Caught Aedes albopictus and Aedes aegypti Mosquitoes in Four States of Northeast India

Vinayagam,

Nirmolia,

Chetry

et al. 2023

Journal of Tropical Medicine

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Wolbachia, a Gram-negative intracellular bacterium, naturally infects many arthropods, including mosquito vectors responsible for the spread of arboviral diseases such as Zika, chikungunya, and dengue fever. Certain Wolbachia strains are involved in inhibiting arbovirus replication in mosquitoes, and this phenomenon is currently being studied to combat disease vectors. A study was conducted in four states in north-eastern India to investigate the presence of natural Wolbachia infection in wild-caught Aedes albopictus and Aedes aegypti mosquitoes, the established vectors of dengue. The detection of a Wolbachia infection was confirmed by nested PCR and sequencing in the two mosquito species Ae. aegypti and Ae. albopictus. Positivity rates observed in Ae. aegypti and Ae. albopictus pools were 38% (44 of 115) and 85% (41 of 48), respectively, and the difference was significant (chi-square = 28.3174, p = 0.00000010). Sequencing revealed that all detected Wolbachia strains belonged to supergroup B. Although Wolbachia infection in Ae. aegypti has been previously reported from India, no such reports are available from north-eastern India. Data on naturally occurring Wolbachia strains are essential for selecting the optimal strain for the development of Wolbachia-based control measures. This information will be helpful for the future application of Wolbachia-based vector control measures in this part of the country.

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Molecular Characterisation and Phylogenetic Analysis of Dengue Outbreak in Pasighat, Arunachal Pradesh, Northeast India

Cited by 8 publications

References 31 publications

Spatiotemporal Distribution of Dengue and Chikungunya in the Hindu Kush Himalayan Region: A Systematic Review

Spatiotemporal Distribution of Dengue and Chikungunya in the Hindu Kush Himalayan Region: A Systematic Review

Epidemiological scenario of dengue in the state of Manipur during the last 3 years

Molecular Evidence of Wolbachia Species in Wild-Caught Aedes albopictus and Aedes aegypti Mosquitoes in Four States of Northeast India

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