2002
DOI: 10.1016/s0960-0760(02)00074-2
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Molecular changes associated with the acquisition of oestrogen hypersensitivity in MCF-7 breast cancer cells on long-term oestrogen deprivation

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Cited by 122 publications
(123 citation statements)
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“…The proliferation profile and time lapse for resistance are in agreement with previous studies (Yue et al, 2003;Martin et al, 2005;Shaw et al, 2006;Sadler et al, 2009). At the latter time point evaluated in this study, MCF7-LTED cells are thought to be in 17bE2-hypersensitive status, which should be acquired at between 3-6 months in 17bE2-deprived culture and precedes acquisition of full 17bE2 independence (Masamura et al, 1995;Santen et al, 2001;Chan et al, 2002;Martin et al, 2003).…”
Section: Resultssupporting
confidence: 90%
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“…The proliferation profile and time lapse for resistance are in agreement with previous studies (Yue et al, 2003;Martin et al, 2005;Shaw et al, 2006;Sadler et al, 2009). At the latter time point evaluated in this study, MCF7-LTED cells are thought to be in 17bE2-hypersensitive status, which should be acquired at between 3-6 months in 17bE2-deprived culture and precedes acquisition of full 17bE2 independence (Masamura et al, 1995;Santen et al, 2001;Chan et al, 2002;Martin et al, 2003).…”
Section: Resultssupporting
confidence: 90%
“…Following these observations, and as a potential second-line therapeutic strategy, we assessed the effect of ICI 182 780 using late-stage (that is, 18 months) MCF7-LTED cells and their parental MCF7 cells. Notably, MCF7-LTED cells were relatively less sensitive to ICI 182 780 (Figure 6a, including controls of ERa and CDK4 levels, right panels), which further supports the hypothesis of full 17bE2 independence at a late time point, but it is in apparent contradiction with previous evidence (Santen et al, 2001;Chan et al, 2002;Martin et al, 2003). An explanation for this discrepancy may be found in the examination of different time points, as there are possibly dynamic profiles after six months in 17bE2-deprived culture.…”
Section: Mechanistic Insight Into Response To Endocrine Therapiessupporting
confidence: 66%
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