Molecular cell biology and cancer metastasis. An interview with Garth Nicolson

Mareel, Marc

doi:10.1387/ijdb.041803mm

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…Every single cell that moves to another place may develop into a new tumour, giving rise to various necrotic regions. Upon treatment even if a single cell or colony is left out, it can again lead to an entire tumour (Mareel 2004;Arspe 2005). Present cancer therapy should be based on the philosophy, 'even a single cancer cell should not remain untreated in the body and nothing less than complete elimination of tumour from an individual can be accepted'.…”

Section: Tumour Physiology and Vasculaturementioning

confidence: 99%

Tumour and dendrimers: a review on drug delivery aspects

Agarwal

Asthana

Gupta

et al. 2008

Journal of Pharmacy and Pharmacology

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Tumour is a morbid state, characterized by spontaneous outgrowth of an abnormal mass of cells. The evolution of tumours is random, disorganized, a condition of numerous mutations. The properties are biased and incompletely comprehended. It is a malignant or benign condition that encompasses its own rules of morphogenesis, an immortal state that elucidates different physiology. It is a pathological crisis that still haunts the minds of scientists, physicians and patients, a complete cure of which is still a dream to be realized. The unpredictable microenvironment of cancerous cells in all of its existing forms i.e. leukaemic cells, solid tumours and sarcomas is well documented. This phenomenon expressed by cancerous sites in the body poses various obstacles towards drug efficacy. Thus, it has become necessary to address briefly the issues relating to tumour physiology, its vasculature and angiogenesis. The information could provide insight towards the development of tumour-targeted drug delivery. The salient features regarding these have been discussed.

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Section: Tumour Physiology and Vasculaturementioning

confidence: 99%

Tumour and dendrimers: a review on drug delivery aspects

Agarwal

Asthana

Gupta

et al. 2008

Journal of Pharmacy and Pharmacology

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Contact Interactions Between Cells That Suppress Neoplastic Development: Can They Also Explain Metastatic Dormancy?

Rubin¹

2008

Advances in Cancer Research

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Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer

Caldeira¹,

Pereira²,

Suriano³

et al. 2009

Int. J. Dev. Biol.

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Mutations in the CDH1 gene, which encodes the cell adhesion molecule E-cadherin, are associated with hereditary diffuse gastric cancer in humans. Although most of the CDH1 mutations found are truncating, leading to non-functional E-cadherin, some are missense. These missense E-cadherin mutants result in full-length proteins which, when assayed in cell culture, still retain some biological activity. In order to understand the molecular causes of the malfunction of the E-cadherin missense forms found in patients, we developed a Drosophila model, where the effects of expressing the mutant forms can be studied in vivo (Pereira et al., 2006). Here, we review the results obtained so far, and outline possible ways of exploiting the fly model system to screen for pathways affected by specific E-cadherin missense mutant forms and to identify mechanisms that contribute to tumourigenesis.

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Molecular cell biology and cancer metastasis. An interview with Garth Nicolson

Cited by 4 publications

References 25 publications

Tumour and dendrimers: a review on drug delivery aspects

Tumour and dendrimers: a review on drug delivery aspects

Contact Interactions Between Cells That Suppress Neoplastic Development: Can They Also Explain Metastatic Dormancy?

Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer

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