Molecular biomarkers for an early diagnosis, effective treatment and prognosis of colorectal cancer: Current updates

Mahasneh, Amjad; Al-Shaheri, Fawaz N.; Jamal, Eshraq

doi:10.1016/j.yexmp.2017.05.005

Cited by 73 publications

(66 citation statements)

References 124 publications

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“…Colorectal cancer (CRC) accounted for 9.7% of all cancers in 2015, and a total of 1 478 000 estimated new cases were recorded worldwide [1][2][3]. The liver is a common site for cancer metastases, and metastatic tumours are detected in up to 50% of individuals with CRC, either within a period of 3 months of initial diagnosis (synchronous) or after (metachronous); this contributes to the poor prognosis of CRC [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

A prognostic nomogram for colorectal cancer liver metastases after percutaneous thermal ablation

Wang

Zheng

Chen

et al. 2017

International Journal of Hyperthermia

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Section: Introductionmentioning

confidence: 99%

A prognostic nomogram for colorectal cancer liver metastases after percutaneous thermal ablation

Wang

Zheng

Chen

et al. 2017

International Journal of Hyperthermia

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“…In China, CRC remains a huge threat to human life due to its high incidence and mortality rates [ 2 ]. Early and accurate detection of the disease based on expression analysis of molecular biomarkers has been proven to be an effective way to improve survival rates in patients with CRC [ 19 , 20 ]. Recent advances in microarray technology have succeeded in elucidating major genetic events that contribute to CRC [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recent advances in microarray technology have succeeded in elucidating major genetic events that contribute to CRC [ 7 ]. As a result, more clues are discerned regarding potentially diagnostic, therapeutic, and prognostic biomarkers that are evident during the progression of CRC [ 19 , 21 – 23 ].…”

Section: Discussionmentioning

confidence: 99%

Identification and Interaction Analysis of Molecular Markers in Colorectal Cancer by Integrated Bioinformatics Analysis

Han

Feng

Yu³

et al. 2018

Med Sci Monit

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BackgroundColorectal cancer (CRC) is an extremely common gastrointestinal malignancy.Material/MethodsThree mRNA and 2 microRNA microarray datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) and microRNAs (DEMs) were obtained. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) program was utilized to perform gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Protein–protein interaction (PPI) network analysis was performed with the Search Tool for the Retrieval of Interacting Genes (STRING) and Cytoscape and Molecular Complex Detection (MCODE). Kaplan-Meier curves were plotted to determine overall survival (OS) estimates. DEMs targets were predicted by miRWalk. Quantitative reverse transcription polymerase chain reaction (QRT-PCR) was utilized to detect the expression of genes and microRNAs.ResultsA total of 264 DEGs and 8 DEMs were obtained. GO analysis revealed that the DEGs were enriched in terms of cell structure, digestion, receptor binding, and extracellular material (ECM). KEGG pathway analysis showed that the DEGs were enriched in ECM interaction and mineral absorption. Additionally, a PPI network consisting of 181 nodes and 450 edges was established. Three modules with 38 high-degree hubs were extracted from the PPI network and found to be involved in pathways such as chemokine signaling. Five DEGs located in the network of DEM-DEG pairs were associated with the overall survival of CRC patients. Furthermore, hsa-miR-551b was demonstrated to be significantly down-regulated in CRC tissues.ConclusionsThe key biomarkers could provide new clues for CRC.

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“…Since all cancer cells produce exosomes from early stages and these EVs play efficient roles in recipient cells, the molecular content of these exosomes may provide unique molecular markers for early diagnosis and prognosis. Therefore, researchers propose that circulating exosomes may provide an effective tool for noninvasive diagnosis and prognosis of human cancers . Moreover, several reports on CRC have also revealed that specific circulating exosomes in the plasma of patients are related to poor prognosis and can be reliable biomarkers for diagnosis of this cancer …”

Section: Exosomes For Diagnosis Of Crcmentioning

confidence: 99%

Exosomes and their importance in metastasis, diagnosis, and therapy of colorectal cancer

Cheshomi

Matin

2018

J of Cellular Biochemistry

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Extracellular vesicles are known as actual intermediaries of intercellular communications, such as biological signals and cargo transfer between different cells. A variety of cells release the exosomes as nanovesicular bodies. Exosomes contain different compounds such as several types of nucleic acids and proteins. In this study, we focused on exosomes in colorectal cancer as good tools that can be involved in various cancer‐related processes. Furthermore, we summarize the advantages and disadvantages of exosome extraction methods and review related studies on the role of exosomes in colorectal cancer. Finally, we focus on reports available on relations between mesenchymal stem cell–derived exosomes and colorectal cancer. Several cancer‐related processes such as cancer progression, metastasis, and drug resistance of colorectal cancer are related to the cargoes of exosomes. A variety of molecules, especially proteins, microRNAs, and long noncoding RNAs, play important roles in these processes. The microenvironment features, such as hypoxia, also have very important effects on the properties of the origin cell–derived exosomes. On the other hand, exosomes derived from colorectal cancer cells also interfere with cancer chemoresistance. Furthermore, today it is known that exosomes and their contents can likely be very effective in noninvasive colorectal cancer diagnosis and therapy. Thus, exosomes, and especially their cargoes, play different key roles in various aspects of basic and clinical research related to both progression and therapy of colorectal cancer.

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Molecular biomarkers for an early diagnosis, effective treatment and prognosis of colorectal cancer: Current updates

Cited by 73 publications

References 124 publications

A prognostic nomogram for colorectal cancer liver metastases after percutaneous thermal ablation

A prognostic nomogram for colorectal cancer liver metastases after percutaneous thermal ablation

Identification and Interaction Analysis of Molecular Markers in Colorectal Cancer by Integrated Bioinformatics Analysis

Exosomes and their importance in metastasis, diagnosis, and therapy of colorectal cancer

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