Molecular biomarkers and liquid biopsies in lung cancer

Sankar, K. Nathan; Zeinali, Mina; Nagrath, Sunitha; Ramnath, Nithya

doi:10.1053/j.seminoncol.2022.06.007

Cited by 2 publications

(2 citation statements)

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“…For instance, it fails to appreciate tumor heterogeneity, and performing repeat invasive biopsies during therapy is difficult and costly. 21 To address these issues, liquid biopsy has emerged as a promising alternative. This approach enables easier and less painful sample procurement, faster processing time, which reduces the turnaround time, and allows for the assessment of tumor heterogeneity and the tumor microenvironment.…”

Section: Discussionmentioning

confidence: 99%

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The digital expression profile of BMP7, CDKN2C, HIST1H3G, and PKMYT1 genes improves high‐grade cervical lesion detection in liquid‐based cytology

Causin

Silva

Leal

et al. 2023

Cancer Cytopathology

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Background: Some studies reported that differential gene expression could be used as a biomarker for high-grade cervical lesion identification. The aim was to evaluate the gene expression profile of cervical intraepithelial neoplasia (CIN) to identify a gene expression signature of CIN2+ in liquid-based cytology (LBC) samples.Methods: LBC samples (n = 85) obtained from women who underwent colposcopy were included with benign (n = 13), CIN1 (n = 26), CIN2 (n = 16), and CIN3 (n = 30) diagnoses. After RNA isolation, gene expression profiling was performed using the nCounter PanCancer Pathways, which consists of 730 cancer-related genes. The genes identified were in silico expression evaluated using the UALCAN database. An accurate prediction model to discriminate CIN2+ from

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Section: Discussionmentioning

confidence: 99%

“…Although most approved biomarkers are based on tumor biopsy specimens, this approach has several limitations. For instance, it fails to appreciate tumor heterogeneity, and performing repeat invasive biopsies during therapy is difficult and costly 21 . To address these issues, liquid biopsy has emerged as a promising alternative.…”

Section: Discussionmentioning

confidence: 99%