Molecular Biology of Cancer and Aging

Balducci, Lodovico; Villalobos, Alice; Kaplan, Laurie

doi:10.1002/9780470344446.ch1

Cited by 3 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Aging is associated with a lower immunological competence, less efficient DNA repair, a greater number of damaged tumor suppressor genes, and a lower number and function of mitochondria. In addition, the functional reserves of the organic systems in geriatric animals are decreased, in addition to sarcopenia and an increase in the prevalence of chronic diseases, which can cause fragility and stress, implying a greater susceptibility to developing cancer [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Pathological Characterization and Risk Factors of Splenic Nodular Lesions in Dogs (Canis lupus familiaris)

Corvera,

Alegría-Morán,

Cifuentes

et al. 2024

Animals

View full text Add to dashboard Cite

In dogs, the spleen is a secondary lymphoid organ that can be affected by both neoplastic and non-neoplastic nodules. In general, few studies relate histopathological diagnosis to tumor size and the number of nodules in spleen biopsies. Some of these studies are inconclusive regarding the difference between neoplastic and non-neoplastic lesions and have small sample sizes or do not consider all splenic lesions. This study aimed to characterize splenic masses and determine risk factors for spleen tumors in dogs. A total of 507 histological reports corresponding to the diagnosis of splenic lesions in dogs from a private laboratory of animal pathology in the Metropolitan Region, Chile, were used. Data were analyzed by descriptive statistics and multiple logistic regression. The most frequent neoplastic and non-neoplastic diagnoses were hemangiosarcoma and hyperplasia, respectively. Most of the cases occurred in male (265 cases, 52.3%), senior (421 cases, 83%), and purebred individuals (342 cases, 67.5%). The most affected breeds were the Cocker Spaniel, German Shepherd, and Labrador Retriever. The most frequent lesion was a single nodule. The variables that exhibited a greater risk for the presentation of splenic neoplasia were male sex (odds ratio (OR) = 16.21; 95% confidence interval (CI) 1.741–150.879; p = 0.014), the presence of two or more splenic nodules (OR = 3.94; 95% CI 2.168–7.177; p < 0.001), an increase in nodule size greater than 2 cm (OR for quartiles 2, 3 and 4 of 2.2; 95% CI 1.036–4.941; p = 0.041, 2.9; 95% CI 1.331–6.576; p = 0.008, and 3.6; 95% CI 1.562–8.499; p = 0.003, respectively), and increasing age (OR = 1.23; 95% CI 1.048–1.436; p = 0.011). On the other hand, males exhibited a lower risk as age increases (OR = 0.76; 95% CI 0.615–0.928; p = 0.008). In conclusion, this study identified that males, multinodular presentation, nodule size, and age are risk factors for the occurrence of splenic neoplasia in dogs, knowledge that will contribute to the diagnostic management of dogs with spleen lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Pathological Characterization and Risk Factors of Splenic Nodular Lesions in Dogs (Canis lupus familiaris)

Corvera,

Alegría-Morán,

Cifuentes

et al. 2024

Animals

View full text Add to dashboard Cite

show abstract

“…O emagrecimento presente em 55% dos animais com linfoma alimentar nesse trabalho pode ser explicada tanto pela má absorção secundária à doença difusa da mucosa intestinal ou à SIBO, associada à êmese, quanto pelo fato de se tratar de uma neoplasia, que pode levar a caquexia provocada por um estado hipermetabólico que, somado à inapetência, resulta em ingestão de proteína e nutrientes insuficientes para suprir as necessidades nutricionais do indivíduo (MAULDIN, 2001;JERGENS, 2005;BALDUCCI, 2007).…”

unclassified

Avaliação citológica, histológica e imunoistoquímica do linfoma alimentar em felinos domésticos

Barriga¹

View full text Add to dashboard Cite

show abstract

A cancer diagnosis — what now?

Kerrigan

2016

The Veterinary Nurse

View full text Add to dashboard Cite

Few words in the English language evoke such depth and variety of emotion as the word cancer ( Lagoni et al, 1994 ). Faced with a spectrum of potential owner reactions, veterinary personnel must provide accurate medical information and appropriate emotional support. For many clients, such a diagnosis in their treasured companion implies pain, discomfort and impending loss of life ( Ciekot, 1995 ). The role of veterinary personnel in a cancer diagnosis includes that of health care provider, teacher and source of emotional support. This article will outline the role of personnel from presentation of the diagnosis and discussion of treatment options, to providing support for the owner and extended family of the pet throughout the cancer journey.

show abstract

Molecular Biology of Cancer and Aging

Cited by 3 publications

References 7 publications

Pathological Characterization and Risk Factors of Splenic Nodular Lesions in Dogs (Canis lupus familiaris)

Pathological Characterization and Risk Factors of Splenic Nodular Lesions in Dogs (Canis lupus familiaris)

Avaliação citológica, histológica e imunoistoquímica do linfoma alimentar em felinos domésticos

A cancer diagnosis — what now?

Contact Info

Product

Resources

About