Molecular Biology of Basal and Squamous Cell Carcinomas

Boeckmann, Lars; Martens, Marie Christine; Emmert, Steffen

doi:10.1007/978-3-030-46227-7_9

Cited by 10 publications

(7 citation statements)

References 205 publications

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“…UV-related alterations on TP53 have been extensively described in melanoma and also in non-melanoma cutaneous cancer [38,39]. TP53 has, indeed, an initial role in cutaneous carcinogenesis in contrast to internal malignancies, where TP53 mutations develop at a later stage [63]. Mutations in the TP53 gene have been described as an early event in SCC development and, as so, are present in AK as well as in other precursor lesions [64,65].…”

Section: Discussionmentioning

confidence: 99%

“…Mutations in the TP53 gene have been described as an early event in SCC development and, as so, are present in AK as well as in other precursor lesions [64,65]. With the help of other molecules including calcitriol, p53 enhances DNA repair in keratinocytes [63,66]. In normal skin p53 is barely present, but is expressed after UV irradiation, suggesting an initial p53 overexpression to overcome the UV-caused DNA damage [65,66].…”

Section: Discussionmentioning

confidence: 99%

“…This fact could be in accordance with the premalignant nature of PTT, but in contrast to AK where mutations occur in TP53 [67], we demonstrate a TP53 deletion in several benign appearing PTT. In this context, it would be interesting to sequence TP53 searching for UVB-signature mutations in PTT, clearly linking to sunlight exposure [63].…”

Section: Discussionmentioning

confidence: 99%

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TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours

et al. 2021

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Proliferating trichilemmal tumours (PTT) are defined by a benign squamous cell proliferation inside a trichilemmal cystic (TC) cavity. A possible explanation of this proliferative phenomenon within the cyst may be molecular alterations in genes associated to cell proliferation, which can be induced by ultraviolet radiation. Among other genes, alterations on TP53 and DNA mismatch repair proteins (MMR) may be involved in the cellular proliferation observed in PTT. Based on this assumption, but also taking into account the close relationship between the sebaceous ducts and the external root sheath where TC develop, a MMR, a p53 expression assessment and a TP53 study were performed in a series of 5 PTT cases, including a giant one. We failed to demonstrate a MMR disorder on studied PTT, but we agree with previous results suggesting increased p53 expression in these tumours, particularly in proliferative areas. TP53 alteration was confirmed with FISH technique, demonstrating TP53 deletion in most cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours

et al. 2021

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“…2,5 Di samping itu, karsinoma sel basal yang memiliki sifat mudah terjadi rekurensi serta invasi ke jaringan sekitarnya, membutuhkan protein actin atau disebut juga dengan smooth muscle actin (SMA) untuk menginduksi motilitas sel tumor ke jaringan sekitarnya. 6,7,8 Berdasarkan gambaran histopatologi serta kaitannya dengan risiko rekurensi, WHO tahun 2018 mengklasifikasikan karsinoma sel basal menjadi 2 kelompok, yaitu karsinoma sel basal kelompok risiko rekurensi rendah yang terdiri dari subtipe nodular, superficial, pigmented, infundibulokistik, dan fibroepitelial. Lalu, karsinoma sel basal kelompok risiko rekurensi tinggi yang terdiri dari subtipe basoskuamosa, sclerosing, infiltrating, karsinoma sel basal dengan diferensiasi sarcomatoid, dan mikronodular.…”

Section: Pendahuluanunclassified

Hubungan Antara Ekspresi Cyclin D1 Dan Smooth Muscle Actin Dengan Karsinoma Sel Basal Kelompok Risiko Rekurensi Rendah Dan Tinggi

Putri

Retnani²,

Yudhanto³

et al. 2022

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Kanker kulit yang tersering dikelompokkan menjadi kanker kulit melanositik dan nonmelanositik. Kanker kulit nonmelanositik menempati urutan kelima terbanyak dari seluruh jenis kanker di dunia dengan jenis yang paling sering adalah karsinoma sel basal. Secara histopatologis karsinoma sel basal dibagi menjadi dua kelompok, yaitu kelompok risiko rekurensi rendah dan tinggi. Sifat Karsinoma sel basal yang proliferatif dan invasif membutuhkan marker yang dapat memprediksi keduanya, di antaranya adalah cyclin D1 dan smooth muscle actin (SMA). Penelitian ini untuk membuktikan adanya hubungan antara ekspresi cyclin D1 dengan karsinoma sel basal kelompok risiko rendah dan tinggi. Desain penelitian adalah observasional analitik dengan metode cross-sectional, sampel penelitian karsinoma sel basal ditetapkan sebanyak 30 sampel, terdiri dari 15 sampel kelompok risiko rekurensi rendah dan 15 sampel kelompok risiko rekurensi tinggi. Ekspresi cyclin D1 dan SMA pada sediaan imunohistokimia dinilai secara semi kuantitatif pada masing-masing kelompok kemudian akan dilakukan uji chi-square. Hasil penelitian ini menunjukkan bahwa ekspresi cyclin D1 memiliki hubungan dengan karsinoma sel basal kelompok risiko rekurensi rendah dan tinggi (p = 0,008 < 0,05), namun tidak berhubungan dengan ekspresi SMA (p = 0,389 > 0,05). Ekspresi cyclin D1 pada karsinoma sel basal kelompok risiko rendah memiliki skor yang lebih rendah dibandingkan dengan kelompok risiko rekurensi tinggi. Sementara pada SMA tidak didapatkan perbedaan yang bermakna. Kesimpulan penelitian ini, ekspresi cyclin D1 memiliki hubungan dengan karsinoma sel basal kelompok risiko rekurensi rendah dan tinggi, sedangkan SMA tidak berhubungan.

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“…However, oncogenicity is not universal in different cell types. Known oncogenes preferentially induce certain types of cancer, e.g., RAS for pancreas cancer [7], MYC for leukemia [8, 9], SRC for sarcomas [10], EGFR for squamous cell carcinoma, glioblastomas, lung cancer [11-13], ERBB2 for breast, salivary gland, and ovarian carcinomas [14, 15]. Although the mechanism of cell transformation initiated by the oncogenes are well studied, how they interact with different cell type-specific transcriptomes is not.…”

Section: Introductionmentioning

confidence: 99%

Transcriptional background effects on a tumor driver gene in a transgenic medaka melanoma model

Abdulsahib

Boswell

et al. 2022

Preprint

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The Xiphophorus melanoma receptor kinase gene, xmrk, is a bona fide oncogene driving melanocyte tumorigenesis of Xiphophorus fish. When ectopically expressed in medaka, it not only induces development of several pigment cell tumor types in different strains of medaka, but also induces different tumor types within the same animal, suggesting its oncogenic activity has a transcriptomic background effect. Although the central pathways that xmrk utilizes to lead to melanomagenesis are well documented, genes and genetic pathways that modulate the oncogenic effect, and alter the course of disease have not been studied so far. To understand how the genetic networks between different histocytes of xmrk-driven tumors are composed, we isolated two types of tumors, melanoma and xanthoerythrophoroma, from the same xmrk transgenic medaka individuals, established the transcriptional profiles of both xmrk-driven tumors, and compared (1) genes that are co-expressed with xmrk in both tumor types, and (2) differentially expressed genes and their associated molecular functions, between the two tumor types. Transcriptomic comparisons between the two tumor types show melanoma and xanthoerythrophoroma are characterized by transcriptional features representing varied functions, indicating distinct molecular interactions between the driving oncogene and the cell type-specific transcriptomes. Melanoma tumors exhibited gene signatures that are relevant to proliferation and invasion while xanthoerythrophoroma tumors are characterized by expression profiles related metabolism and DNA repair. We conclude the transcriptomic backgrounds, exemplified by cell-type specific genes that are downstream of xmrk effected signaling pathways, contribute the potential to change the course of tumor development and may affect overall tumor outcomes.

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Molecular Biology of Basal and Squamous Cell Carcinomas

Cited by 10 publications

References 205 publications

TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours

TP53 Abnormalities and MMR Preservation in 5 Cases of Proliferating Trichilemmal Tumours

Hubungan Antara Ekspresi Cyclin D1 Dan Smooth Muscle Actin Dengan Karsinoma Sel Basal Kelompok Risiko Rekurensi Rendah Dan Tinggi

Transcriptional background effects on a tumor driver gene in a transgenic medaka melanoma model

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