Molecular Biology Methods in Streptomyces rimosus, a Producer of Oxytetracycline

Green and rapid synthesis of biomass carbon dot-based fluorescence sensing for the sensitive determination of oxytetracycline

“…Oxytetracycline (OTC) is a tetracycline antibiotic that has been widely used in animal husbandry to treat infectious diseases in livestock and as a feed additive to promote animal growth due to its low cost and significant antibacterial effect. 1 However, the intake of animal-derived foods with OTC residues can cause liver and kidney damage, flora imbalances, and allergies. 2 Therefore, it is of great significance to establish a simple and reliable method for the detection of OTC in animal-derived foods.…”

Production of secondary metabolites in stirred tank bioreactor co-cultures of Streptomyces noursei and Aspergillus terreus

“…In the case of Streptomyces , a major actinomycete genus, the stirred tank bioreactor system was used by Luti and Mavituna (2011) to demonstrate the elicitation of undecylprodigiosin biosynthesis in Streptomyces coelicolor as a result of co-cultivation with E. coli . Recently, the bioreactor co-cultures involving Streptomyces rimosus , the producer of an antibiotic oxytetracycline ( Slemc et al, 2021 ), and Aspergillus terreus , the fungal producer of a cholesterol-lowering drug lovastatin ( Barrios-González et al, 2020 ), were characterized by our group with regard to a broad spectrum of secondary metabolites and cultivation conditions ( Boruta et al, 2021 ). The study demonstrated the stimulatory effects exerted by A. terreus on S. rimosus (and vice versa), including the induced formation of rimocidin and milbemycin derivates.…”