Molecular biology: an early detector of oral cancers

Ahmed, Siddiq; Mubeen,; Jigna, V.R.

doi:10.1016/j.anndiagpath.2008.12.003

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…Early detection and diagnosis could improve survival rate, but the overall 5‐year rate of 50% was much lower than the other human cancers (2, 3). The incidence and mortality of OSCC had been increasing in developing countries over the last three decades (4). Recently, although radiotherapy and chemotherapy had been used in the patients with OSCC, the survival rate of the patients was not obviously improved and the patients still had poor prognosis of dysfunction and disfigurement (2).…”

Section: Introductionmentioning

confidence: 99%

The correlations between alteration of p16 gene and clinicopathological factors and prognosis in squamous cell carcinomas of the buccal mucosa

Dong

Wang

Fang

et al. 2012

J Oral Pathology Medicine

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Section: Introductionmentioning

confidence: 99%

The correlations between alteration of p16 gene and clinicopathological factors and prognosis in squamous cell carcinomas of the buccal mucosa

Dong

Wang

Fang

et al. 2012

J Oral Pathology Medicine

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“…Recently, few authors have combined all the techniques mentioned above right from cellular detection of atypical cells to molecular methods described in this section of stratify the risk of oral leukoplakic patients using expert-guided data transformation and reconstruction and support vector machine. [41,42] Application of Raman spectroscopy in early detection of oral cancer using exfoliative cytology has also been recently reported. [43]…”

Section: Molecular Analysismentioning

confidence: 99%

The role of exfoliative cytology and molecular biology in oral potentially malignant disorders

et al. 2017

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According to the latest statistics, oral squamous cell carcinoma is the 9 th most common cancer to diagnose worldwide, especially in males and in the developing countries and cause for high mortality and morbidity. Oral potentially malignant disorders (OPMD's) are an important entity associated as precusors for most of these cases which are reversible. Hence, early detection of OPMD's can be very useful. Exfoliative cytology is a practically very easy and patient-friendly method to collect cells from these lesions. They can be subjected to a variety of analysis to help us detect oral cancer in advance. This review describes all the techniques have been used in early detection right from the conventional techniques to molecular diagnostics.

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“…The discovery of salivary protein markers for human disease detection, in particular for oral cancer, Sjogren's syndrome and many other oral diseases were identified by complete analysis and documentation of the proteomic contents in human whole and ductal saliva. [ 21 22 ]…”

Section: Proteomics and Dentistrymentioning

confidence: 99%

Role of proteomics in physiologic and pathologic conditions of dentistry: Overview

et al. 2015

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Proteomics is the study of structure and function of proteins in a large scale. For any living organism, preteins are considered to be the vital part because of its role in metabolic pathways of cells. These proteins not only play a role in physiological condition of the cell but also in altered manner during pathologic conditions. These altered proteins in diseased conditions are called as biomarkers. Several such biomarkers were identified in oral diseaes. This review is a brief note on proteins involved in odontogenesis and list of altered proteins proteins identified in various dental and oral diseases. The knowledge about the role of proteomics in dentistry and the importance of proteomic studies in early diagnosis and prognostic part of oral diseases helps in appliction of precised and sucessful treatment.

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Molecular biology: an early detector of oral cancers

Cited by 8 publications

References 49 publications

The correlations between alteration of p16 gene and clinicopathological factors and prognosis in squamous cell carcinomas of the buccal mucosa

The correlations between alteration of p16 gene and clinicopathological factors and prognosis in squamous cell carcinomas of the buccal mucosa

The role of exfoliative cytology and molecular biology in oral potentially malignant disorders

Role of proteomics in physiologic and pathologic conditions of dentistry: Overview

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