Abstract:Stable and transient transfection in Plasmodium has been use to study gene function and gene regulation, becoming a powerful tool to better understand the biology of this parasite. This technique has helped to elucidate the mechanisms involved in virulence, imune evasion, drug resistance, cell invasion, stage differentiation and others. Plasmodium vivax, the parasite responsible for about 80% of Brazilian malaria cases, and which causes great socio-economical burden for this region cannot be cultured continuou… Show more
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