Molecular biointeractions of biomedical polymers with extracellular exudate and inflammatory cells and their effects on the biocompatibility, in vivo

Ali, S.A.M.; Doherty, Patrick; Williams, David

doi:10.1016/0142-9612(94)90032-9

Cited by 67 publications

(32 citation statements)

References 16 publications

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“…This finding may be due, in part, to the foreign body response. 21,22 As a result of the in vivo implantation, the typical response results in the accumulation of cells such as macrophages around the foreign body leading to a walling off of the region. Free radicals, acidic products, or enzymes produced by these cells during the foreign body response may accelerate degradation.…”

Section: In Vivo Degradationmentioning

confidence: 99%

Biodegradation and in vivo biocompatibility of rosin: a natural film-forming polymer

2003

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INTRODUCTIONThe specific aim of the present study was to investigate the biodegradation and biocompatibility characteristics of rosin, a natural film-forming polymer. Both in vitro as well as in vivo methods were used for assessment of the same. The in vitro degradation of rosin films was followed in pH 7.4 phosphate buffered saline at 37°C and in vivo by subdermal implantation in rats for up to 90 days. Initial biocompatibility was followed on postoperative days 7, 14, 21, and 28 by histological observations of the surrounding tissues around the implanted films. Poly (DL-lactic-co-glycolic acid) (PLGA) (50:50) was used as reference material for biocompatibility. Rate and extent of degradation were followed in terms of dry film weight loss, molecular weight (MW) decline, and surface morphological changes. Although the rate of in vitro degradation was slow, rosin-free films showed complete degradation between 60 and 90 days following subdermal implantation in rats. The films degraded following different rates, in vitro and in vivo, but the mechanism followed was primarily bulk degradation. Rosin films demonstrated inflammatory reactions similar to PLGA, indicative of good biocompatibility. Good biocompatibility comparable to PLGA is demonstrated by the absence of necrosis or abscess formation in the surrounding tissues. The study provides valuable insight, which may lead to new applications of rosin in the field of drug delivery.

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Section: In Vivo Degradationmentioning

confidence: 99%

Biodegradation and in vivo biocompatibility of rosin: a natural film-forming polymer

2003

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“…It is NEW BIOPOLYMERS FOR CIPROFLOXACIN IMPLANT well recognized that the inflammation around implants is a process of normal host defense mechanisms generated as a result of surgical procedures and due to presence of the implanted material. 35,36 The inflammatory responses are dependent upon several factors and are generally expressed in terms of the responses observed over a period of time relative to normal tissue. The observations of the present study showed that the free films of PR, GPR, and PPR were tissue tolerant to the extent tested.…”

Section: Discussionmentioning

confidence: 99%

Novel Biopolymers as Implant Matrix for the Deliveryof Ciprofloxacin: Biocompatibility, Degradation, and In Vitro Antibiotic Release

Fulzele

Satturwar

Dorle

2007

Journal of Pharmaceutical Sciences

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“…The profiles of prepared DES need to be further confirmed in vivo, even though some researchers have suggested that sirolimus metabolism in vitro is similar to that in vivo [23] Drug release process in vitro may be actually different from that in vivo due to changes in environment and acid-base metabolism [23,24].…”

Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> pharmacokinetics of sirolimus-coated stent for tracheal stenosis

Wang¹,

Chen²,

Lin³

et al. 2017

Trop. J. Pharm Res

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Molecular biointeractions of biomedical polymers with extracellular exudate and inflammatory cells and their effects on the biocompatibility, in vivo

Cited by 67 publications

References 16 publications

Biodegradation and in vivo biocompatibility of rosin: a natural film-forming polymer

Biodegradation and in vivo biocompatibility of rosin: a natural film-forming polymer

Novel Biopolymers as Implant Matrix for the Deliveryof Ciprofloxacin: Biocompatibility, Degradation, and In Vitro Antibiotic Release

<i>In vitro</i> pharmacokinetics of sirolimus-coated stent for tracheal stenosis

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