Molecular basis of the A2B in Taiwan

Chang, Chao-Sung; Lin, Kuan-Tsao; Chang, Jan‐Gowth; Lin, Chin-Wein; Hsieh, Li-Ling; Yeh, Chi-Jung; Liu, Ta-Chih

doi:10.1007/s12185-008-0136-x

Cited by 7 publications

(7 citation statements)

References 27 publications

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“…It was found that the clinical figures of the Hb, MCV, and MCH phenotypes in the b + group and b + combined with a 0 -thalassemia group were higher than those in the b 0 and b 0 combined with a 0 -thalassemia groups. These results are consistent with our previous studies (Chang et al, 1994b;Peng et al, 1998).…”

Section: Discussionsupporting

confidence: 94%

Hematological features and molecular lesions of hemoglobin gene disorders in Taiwanese patients

Lin

Shih

Peng

et al. 2010

Int J Lab Hematology

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Hemoglobin (Hb) gene disorders are one of the most common inherited diseases in Taiwan, which include alpha-thalassemia, beta-thalassemia, and Hb variants. In this study, we collected and analyzed mutations found in 930 patients with Hb gene disorders except Hb Bart's Hydrops and beta-thalassemia major. The patients included 650 cases of alpha-thalassemia, 225 cases of beta-thalassemia, 9 cases of alpha-thalassemia combined with beta-thalassemia, and 46 cases of Hb variants or Hb variants combined with alpha-thalassemia or beta-thalassemia. The most common type of alpha0-thalassemia and alpha++-thalassemia mutations in our study were the SEA type deletion and the alpha3.7 deletion, respectively; the most common beta-thalassemia mutation was the IVS-2 nt 654 C-->T mutation; and the most common Hb variant was the HbE. We compared the relationships between genotype and hematological phenotypes of various Hb gene disorders and found that different genotypes of alpha0-thalassemia have similar hematological features. In conclusion, the results of our study provide data of the complex interaction of thalassemias and Hb variants which might be useful for other researchers in this field.

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Section: Discussionsupporting

confidence: 94%

Hematological features and molecular lesions of hemoglobin gene disorders in Taiwanese patients

Lin

Shih

Peng

et al. 2010

Int J Lab Hematology

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“…Test interference from cold reactive antibodies, particularly anti-HI, is also detected on this cell [13,14]. It is to be noted that the A2 phenotype, which is seen in about 25% of group A Caucasians, is rare among Asians, and the inclusion of A2 cells in the reverse group is not necessary [15]. On the other hand, B subgroups are more common among Asians, and careful observations for weakened reactions or mixed-field patterns will discriminate such individuals [16,17].…”

Section: Abo and Hh Blood Groupmentioning

confidence: 99%

mentioning

confidence: 99%

How do we approach dilemmas in red cell testing?

Nadarajan

2016

ISBT Science Series

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Despite the large number of serologically identified red cell antigens to date, it is reassuring to note that in the common clinical scenario, the transfusion laboratory would only likely deal with a narrow range of clinically significant antibodies to specific antigens of blood group systems. Accurate ABO and RhD typing still remains the most crucial step in pretransfusion testing followed by the antibody screen. The correct identification of single antibodies or multiple antibodies and whether they are alloantibodies or autoantibodies is necessary so that corresponding antigen‐negative red cells can be supplied. Clinically insignificant antibodies or what some would denote as ‘nuisance’ antibodies would need to be differentiated from clinically significant antibodies. When discrepancies occur between forward and reverse ABO typing, it is crucial that laboratories resolve the discrepancy before a specific ABO blood group is assigned. The inclusion of O cells in reverse grouping, anti‐H and anti‐A1 lectins in the forward, performing the typing on a range of temperatures using washed red cells and careful interpretation of agglutination patterns, would usually provide an answer. On occasions, a saliva test may be necessary and rarely molecular typing. With regard to RhD typing, test systems should identify RhD‐negative and D‐variant individuals so that D‐negative units can be issued to them. Testing with antisera from different clones, the use of adsorption–elution techniques and RhD.CcEe typing aids in coming to a conclusion, before molecular testing becomes necessary. Extended red cell phenotyping is indicated if the patient is at risk for developing a red cell antibody.

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“…The two most common alleles responsible for A 2 in Japan do not have 1016delC, but have different missense mutations within codon 352, only three codons before the normal stop codon: 1054C > T, Arg352Trp ( A202 ) and 1054C > G, Arg352Gly ( A203 ) [212,213] . The most common A 2 allele among A 2 B donors in Taiwan contains 467C > T, Pro156Leu and 1009A > G, Arg337Gly ( A205 ) [213,214] . This allele is responsible for an imbalance in A 2 and A 2 B phenotype frequencies in Japan.…”

Section: Other Fucosyltransferase Genesmentioning

confidence: 99%

ABO, H, and Lewis Systems

Daniels

2013

Human Blood Groups

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Molecular basis of the A2B in Taiwan

Cited by 7 publications

References 27 publications

Hematological features and molecular lesions of hemoglobin gene disorders in Taiwanese patients

Hematological features and molecular lesions of hemoglobin gene disorders in Taiwanese patients

How do we approach dilemmas in red cell testing?

ABO, H, and Lewis Systems

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