Molecular Basis of Effector Recognition by Plant NB‐LRR Proteins

Nicotiana benthamiana asparagine synthetase associates with IP‐L and confers resistance against tobacco mosaic virus via the asparagine‐induced salicylic acid signalling pathway

“…Over thousands of years, plants and pathogens have co‐evolved antagonistically. This co‐evolutionary battle enables plants to develop multilayered defence mechanisms and allows the pathogen to subvert host defences with a corresponding arsenal of counterstrategies (Bent & Mackey, 2007 , Ma et al, 2012a ). Plant pathogens have evolved virulence factors that interact with host proteins to interfere with host physiological processes and accelerate their infections (Regenmortel & Mahy, 2009 ).…”

Structural Advancement in Shoc2‐MAPK Signaling Pathways in the Treatment of Cancer and Other Diseases

“…The malfunctioning of LRR proteins can result in cancer, schizophrenia, eye and lung diseases. [23] Although these proteins are involved in influencing myriad of physiological processes from viruses [12] to animals [24] and plants [25] and even as potential photoswitchable protein in cell signaling [26] but information regarding their structure and function is not completely understood. These scaffold proteins are sticky in nature and tends to form homo-dimers or higher order oligomers which limits their structural characterization using Xray crystallography techniques.…”