Molecular Basis of Bacterial Adhesion in the Oral Cavity

Mergenhagen, Stephan E.; Sandberg, Ann L.; Chassy, Bruce M.; Brennan, Michael J.; Yeung, M K; Donkersloot, Jacob A.; Cisar, John O.

doi:10.1093/clinids/9.supplement_5.s467

Cited by 41 publications

(24 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to Kolenbrander et al (19), most coaggregation reactions involving E. nuclcattttn and a gratn-positive partner are unitnodal (heating the fusobacteria at 85 C for 30 tnin prevents coaggregation but the satne treattnent to the gratnpositive partner has no effect). Sotne studies have suggested proteinaceous structures such as pili, fimbriae and flagella are involved in coaggregation, hetnagglutination, and bacterial colonization (1,3,4,6,8,27,32,38). E tiucleatttm is known to lack these surface structures, suggesting that the protein tnediator involved in coaggregation is associated with the outer envelope (30,36).…”

Section: Discussionmentioning

confidence: 99%

Coaggregation studies of the Eubacterium species

George

Falkler

1992

Oral Microbiology and Immunology

View full text Add to dashboard Cite

Eubacterium species are gram-positive anaerobic rods that are frequently isolated from subgingival plaque of periodontal pockets. Five Eubacterium species were tested for their ability to coaggregate with 33 oral bacterial strains. Using visual and turbidimetric assays, coaggregation was observed among Eubacterium brachy, Eubacterium nodatum, Eubacterium alactolyticum and Eubacterium limosum strains only when tested with Fusobacterium nucleatum strains; Eubacterium saburreum displayed only weak coaggregation ability. Coaggregation between F. nucleatum and the Eubacterium species was observed over a wide range of concentrations of each organism. The F. nucleatum strains contained a heat labile and the Eubacterium species a heat stabile coaggregation receptor. Arginine, histidine, lysine and glycine inhibited the coaggregation between F. nucleatum and the Eubacterium species. Sugars and other amino acids tested did not inhibit the observed coaggregation. Rabbit anti-F. nucleatum serum completely inhibited coaggregation, but anti-E. brachy serum and normal rabbit serum did not. As these anaerobic microorganisms are frequently isolated from the same oral lesions, the surface interactions observed may be important in the pathogenesis of these polymicrobic infections.

show abstract

Section: Discussionmentioning

confidence: 99%

Coaggregation studies of the Eubacterium species

George

Falkler

1992

Oral Microbiology and Immunology

View full text Add to dashboard Cite

show abstract

“…Type 2 pili have lectin-like binding activity for glycoprotein or glycolipid receptors on various host cells. In addition they bind to cell wall glycans of some oral streptococci to form biofilms (dental plaques) [175].…”

Section: Pili In Gram-positive Bacteriamentioning

confidence: 99%

Pili in Gram-negative and Gram-positive bacteria — structure, assembly and their role in disease

Proft

Baker

2008

Cell. Mol. Life Sci.

449

406

View full text Add to dashboard Cite

Many bacterial species possess long filamentous structures known as pili or fimbriae extending from their surfaces. Despite the diversity in pilus structure and biogenesis, pili in Gram-negative bacteria are typically formed by non-covalent homopolymerization of major pilus subunit proteins (pilins), which generates the pilus shaft. Additional pilins may be added to the fiber and often function as host cell adhesins. Some pili are also involved in biofilm formation, phage transduction, DNA uptake and a special form of bacterial cell movement, known as 'twitching motility'. In contrast, the more recently discovered pili in Gram-positive bacteria are formed by covalent polymerization of pilin subunits in a process that requires a dedicated sortase enzyme. Minor pilins are added to the fiber and play a major role in host cell colonization.This review gives an overview of the structure, assembly and function of the best-characterized pili of both Gram-negative and Gram-positive bacteria.

show abstract

“…[44–46] Intracellular pathogens survive by evading the ability of the host to identify them as non-self. Other species secrete toxins that can alter host cell cycles or stimulate the production of inflammatory substances causing DNA damage.…”

Section: Future Prospectsmentioning

confidence: 99%

The role of bacteria in oral cancer

Chocolatewala¹,

Chaturvedi

Desale³

2010

Indian J Med Paediatr Oncol.

View full text Add to dashboard Cite

Despite the widening interest in the possible association between bacteria and different stages of cancer development, our knowledge in its relation to oral cancers remains inadequate. The aim of this review article is to derive a better understanding on the role of various micro-organisms in the etiogenesis of oral cancers through all the available data on the pubmed. Different bacteria have been proposed to induce carcinogenesis either through induction of chronic inflammation or by interference, either directly or indirectly, with eukaryotic cell cycle and signaling pathways, or by metabolism of potentially carcinogenic substances like acetaldehyde causing mutagenesis. Studies have shown diversity of isolated bacterial taxa between the oral cancer tissue specimens and the control, with Exiguobacterium oxidotolerans, Prevotella melaninogenica, Staphylococcus aureus and Veillonella parvula being specific for tumorogenic tissues. Most isolates are saccharolytic and acid tolerant. Streptococcus anginosus, commonly linked with esophageal and pharyngeal cancers, is not of significance in oral cancers. Similarly, significant salivary specificity is noted for three bacteria, namely, Capnocytophaga gingivalis, P. melaninogenica, and Streptococcus mitis in oral cancer patients, making these species salivary markers for the early detection of oral cancers and thus improving the survival rate significantly. Also, such high degree of bacterial specificity in oral cancers has also provoked the designing of new treatment options for cancer prevention by way of vaccine delivery. However, for the success of these steps, a deeper exploration into this subject with a greater understanding is warranted.

show abstract

Molecular Basis of Bacterial Adhesion in the Oral Cavity

Cited by 41 publications

References 13 publications

Coaggregation studies of the Eubacterium species

Coaggregation studies of the Eubacterium species

Pili in Gram-negative and Gram-positive bacteria — structure, assembly and their role in disease

The role of bacteria in oral cancer

Contact Info

Product

Resources

About