Molecular Basis of Androgenetic Alopecia

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

“…As mentioned earlier, platelets are absolutely essential for hair growth and platelet rich plasma preparations are potentially useful in prevention of hair loss [3][4][5][6][7][8][9][10][11]. Despite the facts that the platelets count in AGA patients was at normal range with 238.16 ± 59.70 × 10 3 platelet/µL, but it was lower than that in control group with 267.79 ± 68.23 × 10 3 platelet/µL (P value < 0.01).…”

“…This kind of baldness is described as progressive loss in pigmented terminal hair on the scalp concurrent with predominant onset in puberty upon increase in sexual hormones [4][5][6]. Histological investigations indicated that elevated androgenic hormones cause marked decrease in hair follicles sizes, probably by decreasing hair progenitor cells [7].…”

Follicular Stem Cells in Androgenetic Alopecia

“…Using this antibody it was apparent that hair follicle bulge cells possess characteristics of SCs such as multipotency, high proliferative potential and quiescence [8]. Human bulge cells have been reported to express CK15 selectively throughout all stages of the hair cycle in different types of follicles [9].…”

Comment on “Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial”

“…It is important to note that the volunteers of Norwood-Hamilton types II, III, III vertex, IV, and V were enrolled in study and investigator analysis for frontal AA was also done but results were not mentioned [ 3 ]. Frontal AA is required to be discussed because of two reasons; firstly, AA can be reasonably treated if treatment will be availed during the early stage of progression [ 6 ]; therefore, effect of PSO on Norwood-Hamilton types II and III should be discussed in future studies. Secondly, in one of the studies comparing botanical treatment of AA (saw palmetto) and finasteride, it was observed that botanical treatment was not effective in treating frontal AA [ 7 ]; therefore, to ascertain the possibility of ineffectiveness or effectiveness of PSO on frontal AA, it is suggested to Cho et al to avail data relating the effect of PSO on frontal AA as it will clear the picture to some extent, though future studies are also desirable.…”

“…Another thing which is important and is a matter of future research is appropriate duration of the study. Study duration should be at least 1 year because there is marked effect of seasonal variation on hormonal levels in males (being peaked during summer and being the least during autumn) which in turn affect the anagen phase of hair growth [ 6 ]. I highly appreciated the results of Cho et al and look forward for the clinical research ascertaining the effect of PSO on frontal AA and variability in its results during long term usage.…”