Molecular basis for the inhibitory role of elastic laminae

Liu, S.Q.; Tefft, Brandon J.; Tieché, Christopher; Alkema, Paul K.; Zhang, A.; Zhang, L.-Q.; Wu, Yi-Ting

doi:10.1016/s0021-9290(06)83821-2

Cited by 1 publication

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“…43 Moreover, elastin fibers contribute to the formation of an internal elastic lamina between the intima and the media. 44 Contractile smooth muscle cells and elastin fibers are arranged in concentric circles to form the rebound functional unit of the vascular wall, providing the artery elasticity of expansion and contraction during the cardiac cycle. The main ECM components in the adventitia are collagen I and III, chondroitin sulfate (CS), and dermatan sulfate proteoglycans such as biglycan, decorin, versican, fibronectin, and many other ECM proteins produced by adventitial fibroblasts.…”

Section: The Interactome Of Vascular Extracellular Matrixmentioning

confidence: 99%

Extracellular Matrix Interactome in Modulating Vascular Homeostasis and Remodeling

Fu,

Zhou,

Wang

et al. 2024

Circulation Research

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The ECM (extracellular matrix) is a major component of the vascular microenvironment that modulates vascular homeostasis. ECM proteins include collagens, elastin, noncollagen glycoproteins, and proteoglycans/glycosaminoglycans. ECM proteins form complex matrix structures, such as the basal lamina and collagen and elastin fibers, through direct interactions or lysyl oxidase-mediated cross-linking. Moreover, ECM proteins directly interact with cell surface receptors or extracellular secreted molecules, exerting matricellular and matricrine modulation, respectively. In addition, extracellular proteases degrade or cleave matrix proteins, thereby contributing to ECM turnover. These interactions constitute the ECM interactome network, which is essential for maintaining vascular homeostasis and preventing pathological vascular remodeling. The current review mainly focuses on endogenous matrix proteins in blood vessels and discusses the interaction of these matrix proteins with other ECM proteins, cell surface receptors, cytokines, complement and coagulation factors, and their potential roles in maintaining vascular homeostasis and preventing pathological remodeling.

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Section: The Interactome Of Vascular Extracellular Matrixmentioning

confidence: 99%