1998
DOI: 10.1101/gr.8.8.826
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Molecular Basis for the Dominant White Phenotype in the Domestic Pig

Abstract: The change of phenotypic traits in domestic animals and crops as a response to selective breeding mimics the much slower evolutionary change in natural populations. Here, we describe that the dominant white phenotype in domestic pigs is caused by two mutations in the KIT gene encoding the mast/stem cell growth factor receptor (MGF), one gene duplication associated with a partially dominant phenotype and a splice mutation in one of the copies leading to the fully dominant allele. The splice mutation is a G to A… Show more

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Cited by 173 publications
(186 citation statements)
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“…This could be an indirect proof of the fact that the Agouti locus would not have any direct effect on this coat colour and (an)other locus (loci) (epistatic over Extension and Agouti) should be involved in determining white coat colour in these animals. Epistatic effects of white caused by KIT gene alleles have been already described in pigs (Fontanesi et al, in press-b;Marklund et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…This could be an indirect proof of the fact that the Agouti locus would not have any direct effect on this coat colour and (an)other locus (loci) (epistatic over Extension and Agouti) should be involved in determining white coat colour in these animals. Epistatic effects of white caused by KIT gene alleles have been already described in pigs (Fontanesi et al, in press-b;Marklund et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…Allelic variants of homologs of rat Kit, or of the gene for the Kit ligand (Kitl; RefSeq NM_021843), are known to cause white coat color variants in mice ( Jackson 1994), pigs (Marklund et al 1998), horses (Haase et al 2007), and stickleback fish (Miller et al 2007). Thus, Kit is an excellent candidate for causing the white coat spots in the rats studied here.…”
Section: Discussionmentioning
confidence: 99%
“…All animal experiments were approved by the Institutional Animal Care and Use Committee of KRIBB (approval number: KRIBB-AEC-17103) and were performed in accordance with the Guide for the Care and Use of Laboratory Animals published by the U.S. National Institutes of Health [18][19][20]. All animals had free access to food and water during the experiments.…”
Section: Animalsmentioning
confidence: 99%