Molecular basis for the association between depression and circadian rhythm

Varinthra, Peeraporn; Liu, Ingrid Y.

doi:10.4103/tcmj.tcmj_181_18

Cited by 9 publications

(6 citation statements)

References 57 publications

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“…In a study by Schwartz et al they found that people who prefer darkness to light are more prone to negative emotional experiences and symptoms [49]. It also seems that darkness and light actually have a biological influence on depression, although the mechanisms are still largely unknown [50,51].…”

Section: Improving From Depression: Darkness and Lightmentioning

confidence: 99%

Digging down or scratching the surface: how patients use metaphors to describe their experiences of psychotherapy

et al. 2021

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Background In the present study, we wanted to explore which metaphors patients suffering from major depressive disorder (MDD) use to explain their experience of being in therapy and their improvement from depression. Methods Patients with MDD (N = 22) received either psychodynamic therapy (PDT) or cognitive behavioral therapy (CBT). They were interviewed with semi-structured qualitative interviews after ending therapy. The transcripts were analyzed using a method based on metaphor-led discourse analysis. Results Metaphors were organized into three different categories concerning the process of therapy, the therapeutic relationship and of improvement from depression. Most frequent were the metaphorical concepts of surface and depth, being open and closed, chemistry, tools, improvement as a journey from darkness to light and depression as a disease or opponent. Conclusions Patient metaphors concerning the therapeutic experience may provide clinicians and researchers valuable information about the process of therapy. Metaphors offer an opportunity for patients to communicate nuances about their therapeutic experience that are difficult to express in literal language. However, if not sufficiently explored and understood, metaphors may be misinterpreted and become a barrier for therapeutic change. Trial registration Clinical Trial gov. Identifier: NCT03022071. Date of registration: 16/01/2017.

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Section: Improving From Depression: Darkness and Lightmentioning

confidence: 99%

Digging down or scratching the surface: how patients use metaphors to describe their experiences of psychotherapy

et al. 2021

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“…It has been noticed that individuals who have insomnia or irregular sleep schedules may experience dysregulation of neurotransmitters involved in mood regulation, such as serotonin, and are more susceptible to developing depression. Moreover, studies have suggested that depressive symptoms could occur due to dysregulation in circadian genes and clock genes, which are important in regulating circadian rhythms and mood [23].…”

Section: Circadian Rhythms Hypothesismentioning

confidence: 99%

A Comprehensive Review of the Pathophysiology of Depression

Fouad,

Tadros,

Michel

2024

Archives of Pharmaceutical Sciences Ain Shams University

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Depression is a common serious mood disorder, which spreads all over the world and is the leading cause of disability. It is mainly characterized by a loss of interest and hope in life. Despite decades of research, the pathophysiology of depression remains incompletely understood. So understanding the pathophysiology of depression is crucial to developing effective treatment strategies, which helps in the improvement of the patient's quality of life and prevents the recurrence. In this review, different mechanisms contributing to the onset, progression, and persistence of depressive symptoms are explained; such as neurotransmitter imbalances, particularly serotonin, norepinephrine, and dopamine as well as neuroinflammation, endocrine disturbances, genetic predisposition, neurostructural changes, Glutamatergic and GABAergic alterations, and finally circadian rhythm disturbances. All these mechanisms were found to be involved in the pathophysiology of depression but unfortunately, it varies between patients, so further studies are required to know much more about the intricate mechanisms and thus develop novel treatments that can make a breakthrough in the treatment and prevention of depression.

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“…Therefore, some patients suffering from depression may also improve after CPAP therapy. One of the explanations as to why depression is more frequent in OSA patients might be the circadian disruption caused by arousals and HIF-1 α overexpression [ 111 , 116 , 117 ].…”

Section: Clinical Implications Of Circadian Rhythm Gene Disruption In Osa Patientsmentioning

confidence: 99%

Disruption of Circadian Rhythm Genes in Obstructive Sleep Apnea Patients—Possible Mechanisms Involved and Clinical Implication

Gabryelska

Turkiewicz

Karuga

et al. 2022

IJMS

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Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent pauses in breathing caused by the collapse of the upper airways, which results in intermittent hypoxia and arousals during the night. The disorder is associated with a vast number of comorbidities affecting different systems, including cardiovascular, metabolic, psychiatric, and neurological complications. Due to abnormal sleep architecture, OSA patients are at high risk of circadian clock disruption, as has been reported in several recent studies. The circadian clock affects almost all daily behavioral patterns, as well as a plethora of physiological processes, and might be one of the key factors contributing to OSA complications. An intricate interaction between the circadian clock and hypoxia may further affect these processes, which has a strong foundation on the molecular level. Recent studies revealed an interaction between hypoxia-inducible factor 1 (HIF-1), a key regulator of oxygen metabolism, and elements of circadian clocks. This relationship has a strong base in the structure of involved elements, as HIF-1 as well as PER, CLOCK, and BMAL, belong to the same Per-Arnt-Sim domain family. Therefore, this review summarizes the available knowledge on the molecular mechanism of circadian clock disruption and its influence on the development and progression of OSA comorbidities.

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Molecular basis for the association between depression and circadian rhythm

Cited by 9 publications

References 57 publications

Digging down or scratching the surface: how patients use metaphors to describe their experiences of psychotherapy

Digging down or scratching the surface: how patients use metaphors to describe their experiences of psychotherapy

A Comprehensive Review of the Pathophysiology of Depression

Disruption of Circadian Rhythm Genes in Obstructive Sleep Apnea Patients—Possible Mechanisms Involved and Clinical Implication

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