Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

Ahmed, A. Razzaque; Anwar, Sarah; Reche, Pedro A.

doi:10.3389/fimmu.2022.807173

Cited by 8 publications

(4 citation statements)

References 63 publications

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“…The enzymelinked immunosorbent assays (ELISA) are a more sensitive method for measuring antibodies to desmoglein-1 and 3. 7 The aim of the paper was to determine the relationship between the results of the indirect immunofluorescence test and the age and gender in newly diagnosed patients with bullous dermatoses.…”

Section: Methodsmentioning

confidence: 99%

Relationship between the age and sex of the patient with the results of the indirect immunofluorescence test in patients with bullous dermatoses

Ninković-Baroš¹,

Balaban²,

Umićević-Šipka³

et al. 2022

Scripta Medica

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Background/Aim: Autoimmune bullous diseases are characterised by the production of autoantibodies to epidermal or subepidermal adhesive proteins. The aim of this study was to determine the relationship between age and sex of patients with the results of indirect immunofluorescence test in patients with newly diagnosed bullous dermatoses. Methods: The investigation presents a retrospective study of newly diagnosed patients with autoimmune bullous diseases at the Clinic for Skin and Venereal Diseases of the University Clinical Centre in Banja Luka in the period 2016-2021. In addition to demographic data, the results of an indirect immunofluorescence test in two titres (≥ 1:10 and ≥ 1:100) were analysed. Results: In this study, almost the same number of patients with pemphigus (45.2 %) and pemphigoid (54.8 %) was found. There were more women than men in the total sample (p = 0.049). The average age of subjects with pemphigoid was higher than that of patients with pemphigus (p = 0.001). 48.2 % of patients with pemphigus and 51.8 % of patients with pemphigoid had a positive indirect immunofluorescence test. A positive test for epidermal intercellular substance in both sexes at a titre ≥ 1:100 is higher than a titre ≥ 1:10 (p = 0.029). Patients with autoantibody titres ≥ 1:100 to desmoglein-1 were statistically significantly older than patients with titres ≥ 1:10 (p = 0.047). Conclusion: Number of patients with pemphigus and pemphigoid were similar, with no difference in sex distribution between the two groups of patients, but patients with pemphigoid were older than patients with pemphigus. The difference between high and low autoantibody titres in both sexes was found only in the group of pemphigus on epidermal intercellular substance and desmoglein-1.

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Section: Methodsmentioning

confidence: 99%

Relationship between the age and sex of the patient with the results of the indirect immunofluorescence test in patients with bullous dermatoses

Ninković-Baroš¹,

Balaban²,

Umićević-Šipka³

et al. 2022

Scripta Medica

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“…They also participate in cellular immunity and the progression of delayed hypersensitivity associated with diseases such as multiple sclerosis, autoimmune type 1 diabetes and rheumatoid arthritis. They also play an important role in the prevention of infection by intracellular pathogens (viruses, bacteria and parasites) [ 6 ].…”

Section: Th1-like Cytokines Associated With Bpmentioning

confidence: 99%

Study of cytokine-induced immunity in bullous pemphigoid: recent developments

Huang,

Hu,

Jiang

2023

Annals of Medicine

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Bullous pemphigoid (BP) is an organ-specific disease. Its pathogenesis has not been clearly studied yet; However, studies in recent years have shown that its pathogenesis is related to T helper cells. The pathogenesis of BP is mainly related to Th2 and Th17-related cytokines. IL-4, IL-5 and IL-13 cause eosinophil recruitment, promote antibody production, trigger pruritus and promote blister formation and other symptoms. IL-17 and IL-23 promote the production of matrix metalloproteinase-9 (MMP-9) by related cells, which causes dermo-epidermal junction (DEJ) separation to form bullae and blisters, and can persist in BP inflammation. The serum concentrations of IL-17 and IL-23 are related to the prognosis of BP. In this paper, we focus on the role of related cytokines in the pathogenesis of bullous pemphigoid and the relationship between the related cytokine populations secreted by three major T helper cells—helper T lymphocytes 1 (Th1), Th2, and Th17. A better understanding of the biological and immunological functions of cytokines associated with BP patients will provide opportunities for therapeutic targets in BP.

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“…Over the recent years, the incidence of BP is raising significantly ( 2 , 8 ). This phenomenon is partly explained by an increasing aging population in western countries, and easier access to serological diagnostic kits.…”

Section: Introductionmentioning

confidence: 99%

The cytokine milieu of bullous pemphigoid: Current and novel therapeutic targets

et al. 2023

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Bullous pemphigoid (BP) is the most common autoimmune bullous disease, characterized by severe pruritus and skin blistering. The loss of tolerance against Collagen XVII, also referred to as BP180, is the main pathogenic event of BP, leading to production of IgG autoantibodies which mainly target the juxtamembranous extracellular non-collagenous 16th A (NC16A) domain of BP180. A complex inflammatory network is activated upon autoantibody binding to the basement membrane zone; this inflammatory loop involves the complement cascade and the release of several inflammatory cytokines, chemokines and proteases from keratinocytes, lymphocytes, mast cells and granulocytes. Collectively, these events disrupt the integrity of the dermal-epidermal junction, leading to subepidermal blistering. Recent advances have led to identify novel therapeutic targets for BP, whose management is mainly based on the long-term use of topical and systemic corticosteroids. As an example, targeting type-2 T-helper cell-associated cytokines, such as Interleukin-4 and interleukin-13 has shown meaningful clinical efficacy in case series and studies; targeting IL-17 and IL-23 has also been tried, owing to an important role of these cytokines in the chronic maintenance phase of BP. In this review article, we discuss the complex cytokine milieu that characterized BP inflammation, highlighting molecules, which are currently investigated as present and future therapeutic targets for this life-threatening disease.

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Molecular Basis for Global Incidence of Pemphigoid Diseases and Differences in Phenotypes

Cited by 8 publications

References 63 publications

Relationship between the age and sex of the patient with the results of the indirect immunofluorescence test in patients with bullous dermatoses

Relationship between the age and sex of the patient with the results of the indirect immunofluorescence test in patients with bullous dermatoses

Study of cytokine-induced immunity in bullous pemphigoid: recent developments

The cytokine milieu of bullous pemphigoid: Current and novel therapeutic targets

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