Molecular Assembly and Self-Assembly: Molecular Nanoscience for Future Technologies

Wild, Michael de; Berner, Simon; Suzuki, Hitoshi; Ramoino, Luca; Baratoff, A.; Jung, Thomas A.

doi:10.2533/000942902777680162

Cited by 15 publications

(13 citation statements)

References 40 publications

(39 reference statements)

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“…Owing to their unique optical and electrical properties, QDs have been extensively used in microelectronics and biomedical and biological research (De Wild et al, 2003). In the past few decades, QDs have been used in a number of commercial applications including optoelectronics, quantum computing, solar cells, light emitting devices, and security inks (Harrison et al, 2000;Wu et al, 2004;Zhao et al, 2006;Hetsch et al, 2011;Qian et al, 2011).…”

Section: Application Of Quantum Dotsmentioning

confidence: 99%

“…Studying the mechanisms of toxicity of NPs will provide a basis for classifying materials for regulatory purposes and prescribing strategies for risk management (Thomas et al, 2006). Cadmium-based QDs are widely used in microelectronics and biomedical research and offer great potential in medical imaging, diagnosis, and therapeutic targeting (De Wild et al, 2003;Gao et al, 2004;Jamieson et al, 2007). Even though previous studies have reported the toxicity of these NPs, the mechanisms related to their toxic effects in cell lines and in animals are still unclear (Wu et al, 2003;Derfus et al, 2004;Kirchner et al, 2005;Samia et al, 2006;Lovric et al, 2005;Hardman, 2006).…”

Section: Rationales For the Researchmentioning

confidence: 99%

“…While the use of nanomaterials is growing rapidly, there is increasing concern that these materials might pose potential risks to human health (Dreher, 2004;Xia et al, 2010). Quantum dots (QDs) are engineered nanoparticles (NPs) and possess unique optical and electronic properties that make them useful materials in microelectronics and biomedical research (De Wild et al, 2003). Cadmium quantum dots including cadmium telluride quantum dots (CdTe-QDs) and cadmium selenide quantum dots (CdSe-QDs) have shown great potential for use as fluorescent tags in therapeutic targeting and in medical and molecular imaging (Chan et al, 2002;Gao et al, 2004;Zhu et al,2013).…”

Section: Introductionmentioning

confidence: 99%

“…Owing to their unique optical and electronic properties, including broad absorption and narrow emission, QDs have been widely used in electronic and medical applications (De Wild et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Quantum dots (QDs) are rapidly emerging as an important class of nanoparticles (NPs) with wide applications in various fields ranging from medicine to energy. These 132 engineered NPs, owing to their unique optical and electronic properties, have been widely used in microelectronics and biological research (De Wild et al, 2003), and have great potential in clinical diagnosis and therapeutic delivery Gao et al, 2004;Scherer et al, 2002). As the use and production of QDs continue to grow, there has been increasing concern about the potential impacts of these NPs on human health and the environment.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Mitchondria in the Potential Hepatotoxicty Caused by Cadmium Telluride Quantum Dot Nanoparticles

Nguyen¹

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Nanotechnology has widespread applications in a variety of fields, thus raising concerns about the potential health risk of nanomaterials. Nanoparticle (NP) toxicity is often linked to their novel physiochemical properties which allow them to be transported across cell membranes or to be taken up into target cells, causing changes in sub-cellular structures and affecting cellular activity. This thesis focused on quantum dots (QDs) which are engineered NPs of semiconductor structures. Cadmium-based QDs such as cadmium telluride QDs (CdTe-QDs), owing to their unique optical and electronic properties, have gained much interest as emerging fluorophores and are widely used in microelectronic and biomedical applications. However, the toxicity associated with these NPs has been a concern and needs to be thoroughly investigated. The overall objectives of this thesis were 1) to examine hepatotoxicity of CdTe-QDs in a hepatocyte cell line and in a mouse model and 2) to investigate mitochondrial effects as the underlying mechanisms of CdTe-QD hepatotoxicity.In HepG2 cells, CdTe-QDs induced cytotoxicity and oxidative stress by increasing reactive oxygen species production and interfering with antioxidant defenses, ultimately activating extrinsic and intrinsic apoptosis pathways. CdTe-QDs also caused mitochondrial toxicity, including mitochondrial enlargement, membrane potential disruption, electron transport chain (ETC) complexes alterations, decreased cellular respiration, ATP depletion, and mitochondrial biogenesis activation. Exposure of BALB/c mice to CdTe-QDs via intravenous injection revealed that the liver was the main target tissue for toxicity.Hepatotoxicity was evidenced by changes in the liver tissue architecture and liver injury biomarkers. At the cellular level, CdTe-QDs induced liver oxidative stress and apoptosis.iii Effects on mitochondria of liver hepatocytes were also observed, including enlargement and increased number of these organelles and effects on ETC complexes and ATP synthesis. This thesis demonstrates that mitochondria are the prominent targets for CdTe-QD hepatotoxicity as mitochondrial dysfunction resulted in energy metabolism impairment and intracellular oxidant stress that signaled apoptotic pathways, leading to observed cytotoxicity and liver damage in the test models. This thesis provides insights into the toxicological mechanisms of QDs in biological systems and helpful information towards bridging the gap between in vitro and in vivo testing for risk assessment of these NPs.iv Acknowledgements I would like to take this opportunity to thank all the people who over the years contributed directly or indirectly to this work and provided help and support in many ways to make this thesis possible and an unforgettable experience for me. First of all, I would like express my deep and sincere gratitude to my supervisors, Dr. Azam Tayabali (Health Canada, Carleton University) and Dr. William Willmore (Carleton University), who have provided me with much guidance, encouragement, and support throughou...

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Section: Application Of Quantum Dotsmentioning

confidence: 99%

Section: Rationales For the Researchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of Mitchondria in the Potential Hepatotoxicty Caused by Cadmium Telluride Quantum Dot Nanoparticles

Nguyen¹

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An in situ Template Route for Fabricating Metal Chalcogenide Hollow Spherical Assemblies Sonochemically

Wang

Zhu

et al. 2004

Eur J Inorg Chem

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An ultrasound-assisted in situ template approach has been developed for fabricating a series of nanoscale metal chalcogenides in the form of well-defined hollow spherical assemblies. These hollow spherical assemblies have well-controlled dimensions and are composed of uniform nanoparticles. Initially, metal hydroxide particles self-assemble into spherical templates generated in situ, and subsequent surface crystal growth leads to hollow spherical structures. Ultrasound irradiation plays a critical role both in the forma-

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Self-Assembly and Nanostructured Materials

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"Nanostructured materials" are those having properties defined by features smaller than 100 nm. This class of materials is interesting for the reasons: i) They include most materials, since a broad range of properties-from fracture strength to electrical conductivitydepend on nanometer-scale features. ii) They may offer new properties: The conductivity and stiffness of buckytubes, and the broad range of fluorescent emission of CdSe quantum dots are examples. iii) They can mix classical and quantum behaviors. iv) They offer a bridge between classical and biological branches of materials science. v) They suggest approaches to "materials-by-design". Nanomaterials can, in principle, be made using both top-down and bottom-up techniques. Self-assembly bridges these two techniques and allows materials to be designed with hierarchical order and complexity that mimics those seen in biological systems. Self-assembly of nanostructured materials holds promise as a low-cost, high-yield technique with a wide range of scientific and technological applications.

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Molecular Assembly and Self-Assembly: Molecular Nanoscience for Future Technologies

Cited by 15 publications

References 40 publications

The Role of Mitchondria in the Potential Hepatotoxicty Caused by Cadmium Telluride Quantum Dot Nanoparticles

The Role of Mitchondria in the Potential Hepatotoxicty Caused by Cadmium Telluride Quantum Dot Nanoparticles

An in situ Template Route for Fabricating Metal Chalcogenide Hollow Spherical Assemblies Sonochemically

Self-Assembly and Nanostructured Materials

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