Molecular aspects of tinnitus

Knipper, Marlies; Zimmermann, Ulrike; Müller, Marcus

doi:10.1016/j.heares.2009.07.013

Cited by 40 publications

(30 citation statements)

References 219 publications

(260 reference statements)

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“…Because stress has been implicated as an aggravating factor, or even a cause, of tinnitus (see, e.g., Knipper, Zimmermann, & Müller, 2010), the question arises as to whether the procedures used here may have increased an animal's level of stress. One potential source of stress is water deprivation, which increases the levels of hormones and proteins (c-Fos) that are associated with stress (Arnhold, Wotus, & Engeland, 2007;Jørgensen, Knigge, Kjaer, & Warberg, 2002).…”

Section: Tinnitus and Stressmentioning

confidence: 99%

A two-choice sound localization procedure for detecting lateralized tinnitus in animals

Heffner

2011

Behav Res

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Rats were trained in a two-choice procedure to respond in the direction of left and right sounds. Silent trials, on which no sound was presented and for which the animals received no feedback, were interspersed among the sound trials to determine each animal's natural side preference. Following training, the rats were exposed to a loud tone in the ear opposite their side preference. A shift in responding on the silent trials to the side of the exposed ear indicated that the animals were hearing a sound in that ear (i.e., tinnitus). Simulating lateralized tinnitus by presenting a low-level, continuous sound on one side also caused the rats to shift their responding on the silent trials to that side. Sham exposures indicated that halothane/nitrous oxide anesthesia could reinstate tinnitus in animals that had previously tested positive for it. Exposing rats to loud tones of various frequencies indicated that frequencies near the limits of the rat's hearing range were less likely to cause tinnitus than tones in the midrange.

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Section: Tinnitus and Stressmentioning

confidence: 99%

A two-choice sound localization procedure for detecting lateralized tinnitus in animals

Heffner

2011

Behav Res

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“…In fact, for one in 100 adults, tinnitus affects their ability to lead a normal day-to-day life [6]. The generation of tinnitus have been linked to damage to the central and peripheral auditory systems, even in cases where an impairment could not be detected by audiometry [7][8][9]. The numbers of patients suffering from tinnitus are increasing day by day and those patients seeking medical advice to alleviate this problem is increasing geometrically across the globe.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Intratympanic Injection of Dexamethasone With 4% Lignocaine for the Treatment of Tinnitus

Ms¹,

Ms.²,

karthick³

2017

IOSR JDMS

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VAS-L/VAS-A) and OtoAcoustic Emissions (OAE) were also noted. Comparative multivariate analyses between indicator factors and tinnitus were conducted. Results: The pre-injection THI scores, VAS-L/VAS-A scores and OAE's recorded and Post injection 30 minutes, 1 day, and 1 week THI scores, VAS-L/VAS-A scores and OAE's recorded showed significant reduction in these levels for both the group. But the 1 month post injection recordings of THI scores, VAS-L/VAS-

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“…27,[60][61][62][63][64][65] The initial shock wave from a blast leads to shearing of tissues, 25 directly injuring the cochlea and leading to an inflammatory response with subsequent neural degeneration. 26 Animal models of TBI demonstrate loss of ribbon synapses from inner hair cells to the auditory nerve in mild cases and then deterioration of outer hair cells of the cochlea, leading to altered auditory nerve activity.…”

Section: Discussionmentioning

confidence: 99%

“…66 Upregulation of BDNF (brain-derived nerve growth factor), a modulator of neuronal plasticity, is noted in spiral ganglion neurons and intracranially, and the spontaneous discharge rate of auditory fibers increases as a result of acoustic trauma. 62 These changes accompany enhanced subcortical disinhibition in the brainstem and inferior colliculus. 67 Disinhibition and prolonged excitation occur along the tonotopic map of the auditory cortex immediately following a loud sound.…”

Section: Discussionmentioning

confidence: 99%

Prospective Associations Between Traumatic Brain Injury and Postdeployment Tinnitus in Active-Duty Marines

Yurgil¹,

Clifford²,

Risbrough³

et al. 2016

Journal of Head Trauma Rehabilitation

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Objective: To examine whether cause, severity, and frequency of traumatic brain injury (TBI) increase risk of postdeployment tinnitus when accounting for comorbid posttraumatic stress disorder. Design: Self-report and clinical assessments were done before and after an "index" deployment to Iraq or Afghanistan. Likelihood of new-onset postdeployment tinnitus was highest for those who were blast-exposed (OR = 2.93; 95% CI, 1.82-6.17), who reported moderatesevere TBI symptoms (OR = 2.22; 95% CI, 1.22-3.40), and who sustained multiple TBIs across study visits (OR = 2.27; 95% CI, 1.44-4.24). Posttraumatic stress disorder had no effect on tinnitus outcome. Conclusions: Participants who were blast-exposed, sustained multiple TBIs, and reported moderate-severe TBI symptoms were most at risk for new-onset tinnitus.

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Molecular aspects of tinnitus

Cited by 40 publications

References 219 publications

A two-choice sound localization procedure for detecting lateralized tinnitus in animals

A two-choice sound localization procedure for detecting lateralized tinnitus in animals

A Comparative Study of Intratympanic Injection of Dexamethasone With 4% Lignocaine for the Treatment of Tinnitus

Prospective Associations Between Traumatic Brain Injury and Postdeployment Tinnitus in Active-Duty Marines

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