Molecular aspects of pancreatic β‐cell dysfunction: Oxidative stress, microRNA, and long noncoding RNA

Borujeni, Mohammad Javad Saeedi; Esfandiary, Ebrahim; Baradaran, Azar; Valiani, Ali; Ghanadian, Mustafa; Codoñer‐Franch, Pilar; Basirat, Reyhane; Alonso‐Iglesias, Eulalia; Mirzaei, Hamed; Yazdani, Amid

doi:10.1002/jcp.27755

Cited by 63 publications

(39 citation statements)

References 183 publications

(308 reference statements)

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“…9,10 Increasing reports indicate that lncRNA regulates the development and progression of human cancers. [11][12][13] LncRNAs may regulate proliferation, invasiveness and differentiation of tumor cells. 14 For example, HOXC-AS2 promotes metastasis of glioma cells by promoting ZEB1 expression.…”

Section: Introductionmentioning

confidence: 99%

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

Liu

Wen

2020

CMAR

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Section: Introductionmentioning

confidence: 99%

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

Liu

Wen

2020

CMAR

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“…Of note, studies have demonstrated that several miRNAs regulate the expression and function of genes involved in pathways leading to oxidative stress in β cells and in tissues involved in diabetic chronic complications [8,9]. Therefore, it could be important to develop therapeutic strategies based on the modulation of the expression of these miRNAs, in order to inhibit or stimulate their activity and to partially relieve cellular dysfunctions caused by oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

Grieco

Brusco

Licata

et al. 2019

IJMS

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Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia as a consequence of pancreatic β cell loss and/or dysfunction, also caused by oxidative stress. The molecular mechanisms involved inβ cell dysfunction and in response to oxidative stress are also regulated by microRNAs (miRNAs). miRNAs are a class of negative gene regulators, which modulate pathologic mechanisms occurring in diabetes and its complications. Although several pharmacological therapies specifically targeting miRNAs have already been developed and brought to the clinic, most previous miRNA-based drug delivery methods were unable to target a specific miRNA in a single cell type or tissue, leading to important off-target effects. In order to overcome these issues, aptamers and nanoparticles have been described as non-cytotoxic vehicles for miRNA-based drug delivery. These approaches could represent an innovative way to specifically target and modulate miRNAs involved in oxidative stress in diabetes and its complications. Therefore, the aims of this review are: (i) to report the role of miRNAs involved in oxidative stress in diabetes as promising therapeutic targets; (ii) to shed light onto the new delivery strategies developed to modulate the expression of miRNAs in diseases.

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“…miRNAs, 18–25 nucleotides in length, are noncoding RNAs that are able to target mRNAs and regulate their expression . In terms of functionality, miRNAs are important agents for gene silencing and post‐transcriptional regulation of proteins.…”

Section: Mirnas As Diagnostic and Prognostic Biomarkers In Hiv Infectionmentioning

confidence: 99%

MicroRNAs and exosomes: key players in HIV pathogenesis

et al. 2019

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Objectives HIV infection is well known to cause impairment of the human immune system, and until recently was a leading cause of death. It has been shown that T lymphocytes are the main targets of HIV. The virus inactivates T lymphocytes by interfering with a wide range of cellular and molecular targets, leading to suppression of the immune system. The objective of this review is to investigate to what extent microRNAs (miRNAs) are involved in HIV pathogenesis. Methods The scientific literature (Pubmed and Google scholar) for the period 1988–2019 was searched. Results Mounting evidence has revealed that miRNAs are involved in viral replication and immune response, whether by direct targeting of viral transcripts or through indirect modulation of virus‐related host pathways. In addition, exosomes have been found to act as nanoscale carriers involved in HIV pathogenesis. These nanovehicles target their cargos (i.e. DNA, RNA, viral proteins and miRNAs) leading to alteration of the behaviour of recipient cells. Conclusions miRNAs and exosomes are important players in HIV pathogenesis. Additionally, there are potential diagnostic applications of miRNAs as biomarkers in HIV infection.

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Molecular aspects of pancreatic β‐cell dysfunction: Oxidative stress, microRNA, and long noncoding RNA

Cited by 63 publications

References 183 publications

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes

MicroRNAs and exosomes: key players in HIV pathogenesis

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