Molecular aspects of depression: A review from neurobiology to treatment

Boas, Gustavo Roberto Villas; Lacerda, Roseli Boerngen de; Paes, Marina Meirelles; Gubert, Priscila; Almeida, Wagner Luis da Cruz; Rescia, Vanessa Cristina; Carvalho, Pablinny Moreira Galdino de; Carvalho, Adryano Augustto Valladão de; Oesterreich, Silvia Aparecida

doi:10.1016/j.ejphar.2019.02.024

Cited by 96 publications

(69 citation statements)

References 291 publications

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“…Over the years, several studies have shown transcriptomic changes in post-mortem brains from psychiatric patients. [50][51][52][53][54][55][56][57] More specifically, these studies identified gene expression changes affecting different neurobiological systems in depressed and suicidal patients such as the GABAergic and glutamatergic systems, the monoaminergic system, the dopaminergic and reward system, 58 the brain-derived neurotrophic factor (BDNF) pathway, and the immune system 50 (for a comprehensive review see 59 ). Gene expression changes in the somatostatin and acetylcholine systems, metallothionein proteins, metal-ion binding proteins, and the MAPK/ERK signaling have been, on the other hand, described in bipolar patients.…”

Section: Human Studiesmentioning

confidence: 99%

“…Apart from the classical stress-related genes presented so far, psychopathologies are known to be characterized by an imbalance in several neurotransmitter pathways. 59 Some of these imbalances are reproduced in chronically stressed rodents and show patterns of sex dimorphism. For instance, the GABAergic pathway in corticolimbic structures seems to be affected in a sex-specific way in response to chronic stress.…”

Section: Targeted Studiesmentioning

confidence: 99%

“…Apart from the classical stress‐related genes presented so far, psychopathologies are known to be characterized by an imbalance in several neurotransmitter pathways . Some of these imbalances are reproduced in chronically stressed rodents and show patterns of sex dimorphism.…”

Section: Chronic Stressmentioning

confidence: 99%

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Sex differences: Transcriptional signatures of stress exposure in male and female brains

Brivio

López

Chen

2020

Genes Brain and Behavior

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More than two‐thirds of patients suffering from stress‐related disorders are women but over two‐thirds of suicide completers are men. These are just some examples of the many sex differences in the prevalence and manifestations of stress‐related disorders, such as major depressive disorder, post‐traumatic stress disorder, and anxiety disorders, which have been extensively documented in clinical research. Nonetheless, the molecular origins of this sex dimorphism are still quite obscure. In response to this lack of knowledge, the NIH recently advocated implementing sex as biological variable in the design of preclinical studies across disciplines. As a result, a newly emerging field within psychiatry is trying to elucidate the molecular causes underlying the clinically described sex dimorphism. Several studies in rodents and humans have already identified many stress‐related genes that are regulated by acute and chronic stress in a sex‐specific fashion. Furthermore, current transcriptomic studies have shown that pathways and networks in male and female individuals are not equally affected by stress exposure. In this review, we give an overview of transcriptional studies designed to understand how sex influences stress‐specific transcriptomic changes in rodent models, as well as human psychiatric patients, highlighting the use of different methodological techniques. Understanding which mechanisms are more affected in males, and which in females, may lead to the identification of sex‐specific mechanisms, their selective contribution to stress susceptibility, and their role in the development of stress‐related psychiatric disorders.

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Section: Human Studiesmentioning

confidence: 99%

Section: Targeted Studiesmentioning

confidence: 99%

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Sex differences: Transcriptional signatures of stress exposure in male and female brains

Brivio

López

Chen

2020

Genes Brain and Behavior

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“…Glucocorticoid (GC) disorder, another important factor that induces depression, often occurred in chronic depression [14,15]. GC binding to the intracellular glucocorticoid receptor (GR) stimulates the translocation of the GR from the cytosol to the nucleus, leading to the transactivation or transrepression of gene transcription [16].…”

Section: Introductionmentioning

confidence: 99%

Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation

et al. 2019

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Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity. However, the regulation of proteomic profiles in neurons suffering CORT stress is remaining elusive. Thus, the proteomic profiles of mouse neuronal C17.2 stem cells were comprehensively investigated by TMT (tandem mass tag)-labeling quantitative proteomics. The quantitative proteomics conjugated gene ontology analysis revealed the inhibitory effect of CORT on the expression of mitochondrial oxidative phosphorylation-related proteins, which can be antagonized by berberine (BBR) treatment. In addition, animal studies showed that changes in mitochondria by CORT can affect neuropsychiatric activities and disturb the physiological functions of neurons via disordering mitochondrial oxidative phosphorylation. Thus, the mitochondrial energy metabolism can be considered as one of the major mechanism underlying CORT-mediated depression. Since CORT is important for depression after traumatic stress disorder, our study will shed light on the prevention and treatment of depression as well as posttraumatic stress disorder (PTSD).

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“…Tal similaridade de sintomas encontra subsídios na fisiopatologia das condições ansiedade e depressão, em que as áreas cerebrais que participam de um dos processos, estão também ligadas ao outro processo. Assim sendo, o sistema límbico e seus núcleos, o hipotálamo, os córtex frontal e pré-frontal, e núcleos do tronco encefálico, participam, de forma geral, do cerne das disfunções ansiogênicas e depressivas, e o que costuma se alterar entre um e outro estado são as informações neuroquímicas subjacentes (o que se traduz em alterações na farmacologia de ambas as condições) (Clark & Beck, 2010;Boas et al, 2019).…”

Section: Resultsunclassified

Ansiedade, Depressão E Análise Não Linear Da Variabilidade Da Frequência Cardíaca Em Ingressantes No Ensino Superior

et al. 2020

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The non-linear analysis of the heart rate variability (HRV) is a potential correlation tool between physiological and emotional states. The aim of this study was correlate changes in non-linear parameters of the HRV with anxiety and depression indices in higher education entrants from Federal University of Goiás (UFG). To record HRV, the Polar Frequency Metermodel Polar® RS800cx (Electro Oi, Finland) was used. To analyze the levels of depression, the Beck Depression Inventory-I (BDI) was used, and for analysis of anxiety, the Inventories of State and Trace (IDATE T and E). Altogether, 50 (19.4±2.48 years) volunteers participated in the study. The scores of the depression and anxiety inventories indicated that the public had low and moderate indices of both conditions, respectively. Statistically significant correlations were found between the SD2 parameter (from the Poincaré plot in the HRV analysis), entropy data (ApEn and SampEn) and fractal property (DFA: α1) and trait and state anxiety levels. Although ApEn e SampEn still do not have well-defined physiological correspondences, DFA: α1 has been associated with parasympathetic modulation of heart rate. Therefore, it is concluded that chronic negative emotional states, such as anxiety and humor disorders, can be accompanied by parasympathetic increase in HRV, so the organism would be able to not wear out against long-term stressors. New studies are necessary to understand the physiological and evolutional bases of depression and anxiety.

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Molecular aspects of depression: A review from neurobiology to treatment

Cited by 96 publications

References 291 publications

Sex differences: Transcriptional signatures of stress exposure in male and female brains

Sex differences: Transcriptional signatures of stress exposure in male and female brains

Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation

Ansiedade, Depressão E Análise Não Linear Da Variabilidade Da Frequência Cardíaca Em Ingressantes No Ensino Superior

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