Molecular Aspects of Angiogenesis in Brain Glioblastomas

Abstract

It is known that angiogenesis plays a critical role in the growth and progression of brain gliomas. Inducing factor in neoangiogenesis are changes primarily occur within the intra-tumoral events: changing the structure of the microvasculature of tumor tissue, increased hypoxia adaptation of tumor cells and the synthesis of angiogenic factors, cell growth. Due to the location of abnormal blood vessels in the tumor tissue generated chaotic flow of blood, which leads to severe hypoxia - as a key factor in inducing the angiogenesis process. Hypoxia-inducible factor 1 (HIF-1) is the main molecule that regulates the growth and progression of glial tumors. Glioma cells, with their inherent properties of stem cells actively synthesized HIF-1. This population of cells called - “glioma stem cells” inducing synthesis of vascular endothelial growth factor (VEGF). It VEGF is central to the process of angiogenesis. A promising area of targeted therapy of brain gliomas is the anti-angiogenic therapy. Applications, both direct and indirect angiogenesis inhibitors, significantly improved the prognosis of patients with glial brain tumors. Undoubtedly an integrated approach to the study of microvascular disturbances, hypoxia, biology and cell behavior of “glioma stem cells” and the role of various factors of cell growth in the tumorigenesis of brain gliomas of the brain allows us to develop new and effective methods of diagnosis and treatment of this disease in the near future.

The Role of 3D Tractography in Skull Base Surgery: Technological Advances, Feasibility, and Early Clinical Assessment with Anterior Skull Base Meningiomas

“…In addition, recent evidence has suggested that the biological behavior and genetic makeup of meningiomas can influence outcomes of surgical resection. [34][35][36] In addition, large meningiomas in this location can have a profound impact on the frontal lobe, resulting in a consistent pattern of postoperative alterations, cystic degenerative changes, parenchymal gliosis, and white matter edema. Taking these factors to consideration, the selected cases of four large OG meningiomas were planned to undergo a staged surgical resection utilizing both dorsal and ventral corridors, given their size, extension, degree of resultant white matter edema, and neurological impact on the patient.…”

Molecular and cellular mechanisms of glioblastoma resistance to vascular endothelial growth factor inhibitors

“…Так, медиана выживаемости пациентов с глиобластомой после выполнения микронейрохирургической резекции и проведения стандартной химио-и лучевой терапии составляет не более 14-16 мес, при этом значение 2-летней выживаемости указанной группы пациентов варьирует от 26 до 33 % [3]. Ангиогенез представляет собой важнейший патофизиологический механизм роста и прогрессирования глиобластомы за счет активного развития микрососудистой сети [4]. Ускоренное развитие микрососудистой сети в глиобластоме происходит благодаря синтезу опухолевыми клетками большого количества фактора роста эндотелия сосудов (Vascular Endothelial Growth Factor, VEGF) [5].…”