Molecular aspects and biochemical regulation of diabetes mellitus

Gyamfi, Daniel; Awuah, Enoch Ofori; Owusu, Stephen

doi:10.1016/b978-0-12-849886-6.00002-1

Cited by 2 publications

(2 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results showed fish oil supplementation could not compromise typical symptoms of diabetes disorder in rats injected with STZ, which are conditions of excessive thirst, excessive urine, increased food consumption, and weight loss ( Gyamfi et al ., 2019 ). These symptoms arise due to insulin deficiency, which causes the body to exchange proteins and fatty acids for energy sources, resulting in weight loss ( Ghule et al ., 2010 ).…”

Section: Discussionmentioning

confidence: 75%

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Titisari,

Fauzi,

Razak

et al. 2023

Open Vet J

View full text Add to dashboard Cite

Background: Fish oil, which is regarded as the primary source of omega-3 fatty acids, has been long studied for its potential as an antidiabetic therapy. However, its protective ability against insulin resistance and pancreatic islet alteration remains unclear and controversial. Aim: To investigate the beneficial effects of fish oil consumption on the progression of insulin resistance and pancreatic islet dysfunction in a rat model of diabetes. Methods: Diabetic rats model (n=30) were divided into 5 groups and received; 1) NS injection+NS oral (NC); 2) NS injection+3g/kg fish oil (FC); 3) STZ injection+NS oral (DC); 4) STZ injection+1g/kg fish oil (DFO1) and 5) STZ injection+3g/kg fish oil (DFO3). Fasting blood insulin was analyzed by commercial rat insulin ELISA assay; meanwhile, the determination of insulin sensitivity was calculated by HOMA-IR and HOMA-B. A histological study was conducted on pancreas tissue using H & E staining. Results: Fish oil supplementation reduced hyperglycemia and ameliorated HOMA IR in STZ-induced animal models indicating that fish oil supplementation improved insulin sensitivity. Furthermore, animals treated with fish oil at a dose of 3g/kg (DFO3) showed an enhancement in pancreatic islets, which was displayed by less abnormal structures than diabetic control animals (DC). This could imply that the administration of fish oil, especially rich in bioactive omega-3 fatty acids effectively inhibits insulin resistance and restore islet of Langerhans alteration in rats injected with STZ. Conclusion: Thus, the current study suggested that fish oil supplementation could support the treatment of diabetes but should not be considered as an alternative therapy.

show abstract

Section: Discussionmentioning

confidence: 75%

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Titisari,

Fauzi,

Razak

et al. 2023

Open Vet J

View full text Add to dashboard Cite

show abstract

“…Adipokines, also known as adipocytokines, are cell-signalling molecules (cytokines) generated by adipose tissue that have an impact on the body's energy/metabolic state, inflammation, obesity, etc. Leptin, adiponectin, resistin, interleukin-6, and tumor necrosis factor are a few prominent adipokines 12 . Among them, we focused on adiponectin because of its following roles in AF.…”

Section: Discussionmentioning

confidence: 99%

Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace

Rafaqat,

Sharif,

Majeed

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Adiponectin, an adipocytokine produced and secreted by adipose tissue, has anti-diabetic, anti-atherogenic, and anti-inflammatory properties. This case-control study was aimed to assess the expression and serum levels of adiponectin in subject suffereing from atrial fibrillation (AF). The study's subjects (n = 690) were enrolled from the Punjab Institute of Cardiology, Lahore and were grouped into control, AF without Metabolic syndrome (MetS), and AF with MetS groups. Along with the collection of demographic data, an analysis of adiponectin and biochemical parameters were performed. A highly significant difference in serum levels of adiponectin was observed among the control, AF without MetS, and AF with MetS groups (61.61 ± 45.30 ng/ml, 37.20 ± 19.46 ng/ml, 63.78 ± 61.69 ng/ml). The expression analysis of adiponectin was decreased (n-fold = ̴ 0.30) in AF without MetS group as compared to control group (n-fold = ~ 1.16) but increased in AF with MetS group (n-fold = ̴ 6.26). The correlation analysis revealed a highly significant positive relationship between the expression of the adiponectin gene with waist-to-hip ratio (WHR) in AF without MetS group. Whereas, serum adiponectin was negatively related to serum triglycerides (TG) in AF with MetS group. In multiple regression analysis using adiponectin expression as the dependent variable, WHR was a determinant in AF without MetS. Whereas, when serum adiponectin was used as the dependent variable, serum TG was the determinant in group AF with MetS. The present study implicates that decreased expression and serum levels of adiponectin were associated with the development of AF in which WHR and serum TG also contributed towards the onset of atrial fibrillation.

show abstract

Molecular aspects and biochemical regulation of diabetes mellitus

Cited by 2 publications

References 81 publications

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Association of adiponectin gene expression with atrial fibrillation in a Pakistani populace

Contact Info

Product

Resources

About