Molecular Architectonics

Two-Dimensional Molecular Architectonics through Controlled Noncovalent Interactions: Structure, Functional Properties, and Applications

“…55 However, 1D architectures were formed with M-and P-helical molecular organization depending on the pH. The conversion of 1D nanowire to 2D nanosheet architectures was reported for a carboxybenzyl (Cbz)-protected L-lysine tetrachloro-PDI derivative (25) in acetone−water. 56 Cbzand carboxylate moiety-induced differential hydrophobic and hydrogen bonding interactions were proposed as the primary driving force for such 1D to 2D architectural transformations (Figure 3m).…”

Cooperative dissolution of peptidomimetic vesicles and amyloid β fibrils

“…The scheme of molecular architectonics allows for the creation of smart molecular architectures with customized size, shape, properties, and functions. [1][2][3][4][5][6][7] In recent years, there has been a surge in research activity focused on developing designer molecular architectures using amphiphiles with variable structural motifs. [8][9][10] Vesicles, in particular, have garnered significant attention due to their unique hollow microstructure, cell penetrability, retention ability, and potential for a wide range of applications including bio-catalysis and bio-medicines.…”

Nanoclusters with specific DNA overhangs: modifying configurability, engineering contrary logic pairs and the parity generator/checker for error detection

“…Although label-free DNA probes have made significant progress, some critical challenges, such as programmability and multifunctional operations, still need to be addressed. [11][12][13][14][15][16] Researchers can control the degree to which NCs can be programmed or customized to have distinct properties by modifying their configurability. Different levels of complexity or specificity can be achieved by adjusting the design of DNA sequence templates and modifying the conditions or analyte interactions.…”

“…The potential application of DNA hybrid architectures in a wide range of disciplines of science has been recognized. 1,4,13,44 Herein, we developed a label-free bimetallic DNA hybrid architecture for molecular logic computation on T-overhang-modified single-stranded DNA-templated NCs by integrating gold (Au III ) and silver (Ag I ) ions (T-Au/Ag NCs), which have been selected as one of the universal platforms for this biocomputing system (Scheme 1). On the other hand, a secondary platform based on chemosensing has been created using a heavy metal (Hg II ) ensemble as a signal receptor named as the M-Au/Ag NCs (T-Au/Ag NCs + Hg II ) platform.…”