Molecular Approaches to Cervical Cancer Therapy

Álvarez-Salas, Luis Marat; DiPaolo, Joseph A.

doi:10.2174/157016307782109661

Cited by 32 publications

(17 citation statements)

References 129 publications

(126 reference statements)

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“…Similar positive results were also acquired from other experiments in non -small cell lung cancer (57). Therefore, in spite of the challenges, the specific targeting of particular oncogenes has proven to be successful in a number of different cancers (58,59). The field is rapidly progressing with the development of chemically modified siRNAs and a variety of novel delivery strategies for future application.…”

Section: Targeting Livin At the Nucleic Acid Levelsupporting

confidence: 77%

Challenge and promise: roles for Livin in progression and therapy of cancer

Wang

Zhang²,

Liu

et al. 2008

Molecular Cancer Therapeutics

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Livin is a member of the inhibitors of apoptosis protein gene family, which is highly expressed in a variety of human neoplasms. Several studies have shown that down-regulation of Livin expression increases the apoptotic rate, reduces tumor growth potential, and sensitizes tumor cells to chemotherapeutic drugs. Furthermore, emerging data reveal that Livin fragments cleavaged by caspases restored paradoxical proapoptotic activity during the apoptotic process, suggesting that Livin cleavage will become a highly potent proapoptotic agent in the future. In this article, we review the current understanding of the versatile roles of Livin in the apoptotic cascade and exploit the promising approach to interfere with Livin as a novel strategy for cancer therapy. [Mol Cancer Ther 2008;7(12):3661 -9]

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Section: Targeting Livin At the Nucleic Acid Levelsupporting

confidence: 77%

Challenge and promise: roles for Livin in progression and therapy of cancer

Wang

Zhang²,

Liu

et al. 2008

Molecular Cancer Therapeutics

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“…6 Tujuan penelitian ini adalah menelusuri asal usul HPV-16 isolat Bandung dengan membuat pohon filogenetik dan optimasi metode untuk menganalisis filogenetik tersebut. …”

Section: Pendahuluanunclassified

Analisis Filogenetik Gen L1 Human Papillomavirus 16 pada Penderita Kanker Serviks di Bandung

Fadhilah¹,

Sahiratmadja²,

Safitri³

et al. 2015

mkb

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AbstrakInfeksi human papillomavirus (HPV) tipe high risk (hr) yang kronik dapat menyebabkan kanker serviks. Berbagai genotipe hrHPV telah teridentifikasi dan HPV-16 merupakan genotipe yang tersering menginfeksi serviks. Fragmen L1 HPV dapat digunakan untuk mengidentifikasikan asal usul HPV. Phylogenetic Analysis of Human Papillomavirus 16 L1 Gene from Cervical Cancer Patient in Bandung AbstractChronic infection with high-risk (hr) human papillomavirus (HPV) can lead to cervical cancer. Various hrHPV genotypes have been identified and HPV genotype 16 is the most common genotypes that infect cervical cancer. HPV L1 fragment can identify the origin of HPV. The purpose of this study was to explore the origins of HPV-16 by making a phylogenetic tree. This study used analytical descriptive method and was was conducted at the Laboratory of Molecular Genetics, Health Research Unit, Faculty of Medicine, Universitas Padjadjaran Bandung in the period of February to August 2013. Biopsy from cervical cancer patient was donated by the Department of Obstetrics, Faculty of Medicine, Universitas Padjadjaran, Bandung. Isolation of DNA was prepared from tissue biopsies of cervical cancer and L1 fragment was amplified with the specific primer. Infection with HPV-16 was confirmed by Linear Array test (Roche) design. The sequence then was constructed using the phylogenetic program (MEGA5). Results showed that the isolate from patient with cervical cancer from Bandung was in one subgroup with HPV from Asia and East Asia. In conclusion, cluster HPV of Bandung is in the same strain as the strain in Asia and East Asia. [MKB. 2015;47(3):174-78]

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“…HPV evolutionary analysis revealed the African origin of the virus [Alvarez-Salas and DiPaolo, 2007] and its dissemination throughout the world. Among the oncogenic HPVs, HPV 16 and 18 are the types detected most frequently in cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity of human papillomavirus type 16 E6, E7, and L1 genes in Italian women with different grades of cervical lesions

Cento¹,

Ciccozzi

Ronga³

et al. 2009

Journal of Medical Virology

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High-risk human papillomaviruses (HPVs) are risk factors for the development of cervical cancer. HPV 16 is the most common type, being present in about 60% of cervical cancers worldwide. Previous studies have reported upon the association between HPV 16 E6 variants and increased risk of cervical intraepithelial neoplasia and invasive cervical cancer. In this study, the presence of HPV 16 polymorphisms in the E6, E7, and L1 genes was investigated in relation to the presence of highgrade lesions. Sequencing of the E6 gene revealed the presence of nucleotide mutations resulting in 15 amino acid changes. Of these, the G134D and C136R fall within the CXXC zinger finger domain important for p53 binding. In the E7 gene, four nucleotide variations were identified with two leading to the amino acid substitutions L15V and S31R. The L1 gene showed 13 nucleotide changes leading to 11 amino acid substitutions. Among these, the R364C and N367D are located at the base of the HI-loop of the L1 protein, considered to be the immunodominant epitope of HPV 16. No significant relationship between HPV 16 variants and high-grade lesions was found. Phylogenetic analysis showed that all the HPV 16 variants identified belonged to the European lineage, except one which was of the Asian-American lineage. The European-350G variant was detected most frequently (22 of 34, 64.7%). The study provides some new data on the genetic diversity of HPV 16 which may help to understand the oncogenic potential of the virus and to improve management of patients.

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Molecular Approaches to Cervical Cancer Therapy

Cited by 32 publications

References 129 publications

Challenge and promise: roles for Livin in progression and therapy of cancer

Challenge and promise: roles for Livin in progression and therapy of cancer

Analisis Filogenetik Gen L1 Human Papillomavirus 16 pada Penderita Kanker Serviks di Bandung

Genetic diversity of human papillomavirus type 16 E6, E7, and L1 genes in Italian women with different grades of cervical lesions

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